全文获取类型
收费全文 | 508篇 |
免费 | 28篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 27篇 |
妇产科学 | 11篇 |
基础医学 | 55篇 |
口腔科学 | 3篇 |
临床医学 | 34篇 |
内科学 | 158篇 |
皮肤病学 | 20篇 |
神经病学 | 19篇 |
特种医学 | 16篇 |
外科学 | 104篇 |
综合类 | 17篇 |
预防医学 | 36篇 |
眼科学 | 3篇 |
药学 | 13篇 |
中国医学 | 1篇 |
肿瘤学 | 17篇 |
出版年
2023年 | 4篇 |
2022年 | 4篇 |
2021年 | 10篇 |
2020年 | 4篇 |
2019年 | 15篇 |
2018年 | 18篇 |
2017年 | 8篇 |
2016年 | 3篇 |
2015年 | 9篇 |
2014年 | 14篇 |
2013年 | 15篇 |
2012年 | 36篇 |
2011年 | 51篇 |
2010年 | 32篇 |
2009年 | 15篇 |
2008年 | 33篇 |
2007年 | 38篇 |
2006年 | 21篇 |
2005年 | 25篇 |
2004年 | 21篇 |
2003年 | 22篇 |
2002年 | 17篇 |
2001年 | 11篇 |
2000年 | 12篇 |
1999年 | 13篇 |
1998年 | 6篇 |
1997年 | 5篇 |
1996年 | 5篇 |
1994年 | 2篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 7篇 |
1988年 | 5篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1981年 | 1篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1977年 | 5篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1969年 | 5篇 |
1968年 | 2篇 |
1967年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有537条查询结果,搜索用时 15 毫秒
1.
Christian Holm Hansen Shelley Lees Saidi Kapiga Janet Seeley Tony Barnett 《Global public health》2020,15(3):402-413
ABSTRACTMeasuring hope reliably and accurately remains an important research objective, not least in less prosperous settings where ‘holding on to hope’ may be critically important in the struggle against adverse life conditions. The State Hope Scale was designed for use in the US. Despite reported application in diverse cultures and using translations the scale has not been extensively validated outside US populations. This study contributes to a larger project exploring the measurement of hope and provides a critique of Snyder’s scale as used in a Tanzanian female population of 1021 urban microfinance participants. We evaluate the scale’s validity through assessment of the empirical distribution of scores, item response profiles, internal consistency and discriminatory ability. Participants mostly scored very high and many reached very near the maximum attainable score. Hardly any endorsed the negative half of the response scale. Several problems are discussed including poor discrimination and strong evidence of acquiescence response bias. We also found little association of the scale scores with hypothesised correlates of hope. Future improvements on the measurement of hope are recommended, especially in studies outside the narrow Western context in which the scale was devised. 相似文献
2.
N. Fredj M. Touffahi R. Saidi M. Lefi A. Achour M. Gahbiche C. Hafsa A. Zakhama H. Saad 《The African Journal of Urology》2008,14(1):43-49
Fungus balls as a cause of upper urinary tract obstruction are rare, with less than 60 cases reported in the literature. We herein describe three cases pf secondary anuria caused byCandida infection of the upper urinary tract. The first case was observed in a patient with a transplanted kidney, the second in a diabetic patient and the third in a patient suffering from chronic kidney failure. The treatment consisted of urinary drainage, identification of the infectious organism and appropriate antifungal treatment. 相似文献
3.
4.
5.
6.
7.
Chaker Ben Salem Wafa Saidi Sofiene Larif Neila Fathallah Raoudha Slim Houssem Hmouda 《Indian journal of pharmacology》2015,47(1):123-124
Allopurinol hypersensitivity syndrome (AHS) is a severe drug reaction. It is characterized by rash, fever, and internal organ involvement. It may present in different clinical forms. We present a case of acute generalized exanthematous pustulosis occurring as a manifestation of AHS.KEY WORDS: Allopurinol, hypersensitivity syndrome, pustulosis 相似文献
8.
9.
Watson-Jones D Baisley K Ponsiano R Lemme F Remes P Ross D Kapiga S Mayaud P de Sanjosé S Wight D Changalucha J Hayes R 《The Journal of infectious diseases》2012,206(5):678-686
Background.We compared vaccine coverage achieved by 2 different delivery strategies for the quadrivalent human papillomavirus (HPV) vaccine in Tanzanian schoolgirls. Methods.In a cluster-randomized trial of HPV vaccination conducted in Tanzania, 134 primary schools were randomly assigned to class-based (girls enrolled in primary school grade [class] 6) or age-based (girls born in 1998; 67 schools per arm) vaccine delivery. The primary outcome was coverage by dose. Results.There were 3352 and 2180 eligible girls in schools randomized to class-based and age-based delivery, respectively. HPV vaccine coverage was 84.7% for dose 1, 81.4% for dose 2, and 76.1% for dose 3. For each dose, coverage was higher in class-based schools than in age-based schools (dose 1: 86.4% vs 82.0% [P?=?.30]; dose 2: 83.8% vs 77.8% [P?=?.05]; and dose 3: 78.7% vs 72.1% [P?=?.04]). Vaccine-related adverse events were rare. Reasons for not vaccinating included absenteeism (6.3%) and parent refusal (6.7%). School absenteeism rates prior to vaccination ranged from 8.1% to 23.5%. Conclusions.HPV vaccine can be delivered with high coverage in schools in sub-Saharan Africa. Compared with age-based vaccination, class-based vaccination located more eligible pupils and achieved higher coverage. HPV vaccination did not increase absenteeism rates in selected schools. Innovative strategies will be needed to reach out-of-school girls. Clinical Trials Registration. NCT01173900. 相似文献
10.
TLR3 is a key receptor for recognition of double-stranded RNA and initiation of immune responses against viral infections. However, hyperactive responses can have adverse effects, such as virus-induced asthma. Strategies to prevent TLR3-mediated pathology are therefore desired. We investigated the effect of single-stranded DNA oligonucleotides (ssDNA-ODNs) on TLR3 activation. Human monocyte-derived dendritic cells up-regulate maturation markers and secrete proinflammatory cytokines on treatment with the synthetic TLR3 ligand polyinosine-polycytidylic acid (poly I:C). These events were inhibited in cultures with ssDNA-ODNs. Poly I:C activation of nonhematopoietic cells was also inhibited by ssDNA-ODNs. The uptake of poly I:C into cells was reduced in the presence of ssDNA-ODNs, preventing TLR3 engagement from occurring. To confirm this inhibition in vivo, we administered ssDNA-ODNs and poly I:C, alone or in combination, via the intranasal route in cynomolgus macaques. Proinflammatory cytokines were detected in nasal secretions in the poly I:C group, while the levels were reduced in the groups receiving ssDNA-ODNs or both substances. Our results demonstrate that TLR3-triggered immune activation can be modulated by ssDNA-ODNs and provide evidence of dampening proinflammatory cytokine release in the airways of cynomolgus macaques. These findings may open novel perspectives for clinical strategies to prevent or treat inflammatory conditions exacerbated by TLR3 signaling. 相似文献