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排序方式: 共有276条查询结果,搜索用时 15 毫秒
1.
Japan Pancreatoduodenectomy Study Group Ryo Hosotani Masafumi Kogire Tadahiro Takada Hiroyuki Kato Takahiko Funabiki Masumasa Horisawa Takeshi Morimoto Takukazu Nagakawa Toshimichi Nakayama Itsuo Miyazaki Masayuki Imamura 《Journal of Hepato-Biliary-Pancreatic Surgery》1997,4(3):295-303
Endocrine tumor of the pancreas is potentially malignant. A multicenter analysis of these tumors was conducted to clarity
the present status of their surgical management and the subsequent long-term surgical results. The Japan pancreatoduodenectomy
(JPD) study group carried out the study; 368 patients were enrolled and variables related to tumor characteristics, surgery,
and survival were retrospectively analyzed. There were 222 patients with functioning tumor and 143 patients with nonfunctioning
tumor. Malignant tumor was found in 140 of 368 (38%) of the patients, and 63/140 (45%) of these patients had metastatic lesion;
the most common site of the metastasis was liver 34/136 (25%), followed by regional lymph nodes 26/136 (19%). Pancreatic resection
was performed in 91% of patients with nonfunctional tumor and in 83% of those with malignant tumor, and 73% of the pancreatic
resections were done with lymph node dissection. The overall 5-year actuarial survival rate was 76% in patients with malignant
tumor. The actuarial 5-year survival rate was 93% in the patients without metastasis and 83% in patients who received curative
resection. Multivariate analysis showed that the presence or absence of synchronous metastasis was the sole significant prognostic
factor. The results suggest that: (i) malignant endocrine tumor of the pancreas is a curable malignancy when pancreatic resection
with lymph node dissection is adopted and (ii) that synchronous metastasis is the dominant prognostic factor.
This study was carried out as a group project. The authors' institutions are as follows 相似文献
2.
Y Kajigaya K Ikuta H Sasaki Y Koiso T Funabiki S Matsuyama 《Journal of Japan Haematological Society》1988,51(5):832-838
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Sakurai Y Shoji M Matsubara T Imazu H Hasegawa S Ochiai M Funabiki T Mizoguchi Y Kuroda M Kasahara M 《Pathology international》2000,50(8):655-659
Angiomyomatous hamartoma is a rare disease with a predisposition for the inguinal lymph nodes. A 51-year-old male patient visited a local hospital because of a right inguinal mass, measuring 3 x 4 cm in size, which was resected. The resected specimen showed irregularly distributed thick-walled vessels in the hilum, extending into the medulla and focally into the cortex of the node, eventually becoming more dispersed and associated with smooth muscle cells splaying into sclerotic stroma. These findings are compatible with an angiomyomatous hamartoma. Another tumor-like mass appeared shortly after the resection at the same location, but was not an angiomyomatous hamartoma, rather it was composed of edematous stromal tissue with proliferating smooth muscle cells. The stromal component included thick-walled blood vessels and lymphatics. Although it could not be determined whether these associated changes in the surrounding stroma are a cause or an effect of angiomyomatous hamartoma, they indicate the clinical difficulty in determining an appropriate area of resection and may provide clues to the pathogenesis of angiomyomatous hamartoma. 相似文献
6.
Yasuhiko Tomino Kazuhiko Funabiki Isao Shirato Hikaru Koide Kazuhiko Eguchi Mitsunori Yagame Hideto Sakai 《Pathology international》1989,39(5):296-305
Computer imaging analysis was used for quantitative evaluation of the extents, amounts and distributions of glomerular extracellular components, such as the 7S and NC 1 domains of type IV collagen, laminin (LN), fibronectin (FN) and IgA, in glomeruli from patients with IgA nephropathy. Renal biopsy specimens from 13 patients with IgA nephropathy were incubated with mouse monoclonal antibodies against the FN or non collagenous (NC 1) domain of type IV collagen or polyclonal antiserum against the LN or 7S domain of human type IV collagen, and then stained with appropriate dilutions of FITC labeled anti mouse Ig antisera. Marked staining of the 7S or NC 1 domain of type IV collagen, LN or FN was detected in the glomerular capillary walls and/or mesangial areas in patients with IgA nephropathy. In particular, a prominent increase of FN was observed in the subendothelial regions of glomerular capillary walls, i.e. mesangial interposition, in the moderate or advanced stage of IgA nephropathy. Therefore, computer imaging analysis was shown to be useful for the quantitative determination of such components distributed in glomeruli from patients with IgA nephropathy. Acta Pathol Jpn 39: 296 305, 1989. 相似文献
7.
Gallbladder torsion: case report and review of 245 cases reported in the Japanese literature 总被引:4,自引:0,他引:4
Nakao A Matsuda T Funabiki S Mori T Koguchi K Iwado T Matsuda K Takakura N Isozaki H Tanaka N 《Journal of Hepato-Biliary-Pancreatic Surgery》1999,6(4):418-421
We report here a case of torsion of the gallbladder in a 73-year-old woman. The patient was admitted to our hospital with
right hypochondralgia. Ultrasonography and computed tomography demonstrated a distended gallbladder, with a multilayered wall,
which contained no stones. Since the symptoms did not respond to antibiotics, laparotomy was performed. The gallbladder was
found to be twisted around its pedicle and to be gangrenous. Cholecystectomy was performed, and the patient had an uneventful
postoperative course. We also reviewed 245 cases reported in the Japanese literature. The clinical features of gallbladder
torsion, which include low frequency of fever and jaundice, poor response to antibiotic therapy, and acute onset of abdominal
pain, may be helpful in the differential diagnosis from acute cholecystitis. Moreover, a highly suggestive sign of gallbladder
torsion observed by ultrasonography or computed tomography is a markedly enlarged "floating" gallbladder with a continuous
hypoechoic line indicating edematous change in the wall.
Received for publication on Feb. 8, 1999; accepted on April 21, 1999 相似文献
8.
Funabiki K Masuoka H Shimizu H Emi Y Mori T Ito M Nakano T 《Japanese heart journal》2003,44(5):767-774
Cholesterol crystal embolization (CCE) is a complication of atherosclerosis. A 67-year-old Japanese man underwent coronary artery bypass grafting. After the surgery, he underwent coronary angiography via the right femoral artery. Twelve days later, he suddenly developed acalculous cholecystitis and was treated with antibiotics. Gradual deterioration in renal function, purplish discoloration of the distal portion of his toes, and eosinophilia were noted. We performed a skin biopsy and made a diagnosis of CCE. Cilostazol and intravenous heparin improved the symptoms and decreased the creatinine level. We retrospectively studied the clinical features of 36 cases registered with a diagnosis of CCE in the Japanese literature. 相似文献
9.
Takahiko Funabiki Yoichi Sakurai Masahiro Ochiai Yoshihisa Marugami Toshiki Matsubara Shigeru Hasegawa 《Journal of hepato-biliary-pancreatic sciences》1997,4(1):71-77
End-to-side choledochoduodenostomy was originally used for reconstruction between the duodenum and the biliary tree in iatrogenic bile duct stricture. However, we believe the procedure could be applied for various biliary disorders. We have recently shown the high carcinogenicity of biliary epithelium in patients with pancreaticobiliary maljunction, and consequently we recommend excision of the bile duct, along with appropriate reconstruction of the biliary system to divert the flow of pancreatic juice from bile fluid, to prevent carcinoma in biliary epithelium even in patients without dilatation of the bile duct. The conditions causing primary or recurrent bile duct stones must be removed. We employed this procedure for biliary reconstruction in 42 patients with pancreatico-biliary maljunction and in 30 patients with various benign biliary diseases, such as bile duct stones and benign biliary stenosis. We also used the procedure for palliation in 6 patients with malignant tumors around the head of the pancreas. Among these 78 patients over 20 years, we experienced 5 cases of reflux cholangitis with anastomotic stenosis, for which conservative dilatation was required. This procedure of end-to-side choledochoduodenostomy could be widely applicable for biliary reconstruction in terms of its being simplicity, minimal invasiveness and the establishment of a single physiological route for bile flow into the duodenum. 相似文献
10.
Incidence of human parvovirus B19 DNA detection in blood donors 总被引:2,自引:0,他引:2
Yuko Yoto Tooru Kudoh Keiji Haseyama Nobuhiro Suzuki Takanori Oda Toshiaki Katoh Tsuneo Takahashi Sadami Sekiguchi Shunzo Chiba 《British journal of haematology》1995,91(4):1017-1018
Summary. 1000 serum samples from blood donors were tested for human parvovirus B19 (B19) DNA by a nested PCR assay: six samples were positive for B19 DNA. The frequency was 1/167 (0-6%), considerably higher than previous surveys (0-004-0-03%). Five of the six samples were also positive for anti-B19 IgM, indicating an acute phase of infection. It is recommended to screen for B19 DNA in blood products to prevent transfusion mediated viral infection for those susceptible such as immunocompromised patients and pregnant women. 相似文献