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排序方式: 共有1712条查询结果,搜索用时 31 毫秒
1.
PJ Commerford 《Cardiovascular journal of Africa》2015,26(4):151-Aug;26(4):151
2.
Hans Bosma Martin PJ van Boxtel Gertrudis IJM Kempen Jacques ThM van Eijk Jelle Jolles 《BMC public health》2007,7(1):179
Background
The aims of this study were to examine the extent to which higher intellectual abilities protect higher socio-economic groups from functional decline and to examine whether the contribution of intellectual abilities is independent of childhood deprivation and low birth weight and other socio-economic and developmental factors in early life. 相似文献3.
4.
5.
Previous reports in the literature have described correlation of increasing repeat length with severity of the phenotype, in Kennedy syndrome. We describe male siblings with different repeat lengths, with lack of expression of the phenotype in the sibling with the longer repeat length. The phenotype was identical to motor neurone disease. There is variability of expression in Kennedy syndrome and repeat length even in siblings cannot be taken as a conclusive indicator of severity. CAG repeat length cannot be used to predict the natural history of Kennedy disease. The diagnosis of Kennedy syndrome should be considered in male patients presenting with atypical motor neurone disease. 相似文献
6.
PJ Woll PhD MRCP R Pettengell PhD FRACP 《International journal of clinical practice》1997,51(2):111-115
SUMMARY The interferons are natural glycoproteins secreted in response to various stimuli, including viral infection. They have antiviral, antiproliferative and immunomodulatory effects on different target cell populations. Since recombinant human interferons have become available, they have been tested in a wide range of malignancies. They are well established in the treatment of hairy cell leukaemia, chronic myelogenous leukaemia and multiple myeloma. Although they have documented activity against lymphoma, melanoma, renal cell cancer and carcinoid tumours, their role in the treatment of these tumours is less clear. In the common solid tumours, such as lung cancer and colorectal cancer, the use of interferons remains experimental. Here we will summarise their practice applications in oncology, using randomised studies where available to establish their place in multi-modality treatment. We will not discuss their use as antiviral or immunomodulating agents in viral and autoimmune diseases, multiple sclerosis or after organ transplantation. 相似文献
7.
Summary. Bone mineralisation during and after limb lengthening procedures on the femur or tibia using unilateral fixators has been
monitored quantitatively using dual energy X-ray absorptiometry (DEXA). We measured the bone mineral density (BMD) prospectively
in the newly formed callus, in the bone adjacent to the callus and in the proximal femur. In twenty-one patients we showed
a typical course with a peak value at 4 – 6 weeks after beginning distraction and a minimum value at maximum distraction.
In the consolidation period the BMD in the distraction gap increased until the fixator was removed. The BMD in the regenerated
bone increased faster in the regions of interest (ROI) opposite the fixator compared to those near it. Dynamisation caused
more homogeneous regeneration equalising V
BMD
in the different ROIs. The BMD in the proximal femur of the leg which was operated on decreased to 67% and in the opposite
leg to 87% of the preoperative value. DEXA provides a precise and quantitative assessment of callus and bone mineralisation
during limb lengthening and helps in understanding what is happening during these procedures.
Accepted: 11 July 1996 相似文献
Résumé. Le processus de la minéralisation peut précisément être étudié d’une manière quantitative pendant et après la distraction du cal au moyen de l’absorptiométrie en énergie-binaire (DEXA) en créant une petite radioexposition. Des patients (n = 21) avec une distraction du cal, auxquels nous avons mesuré prospectivement la densité minérale de l’os (bone mineral density = BMD) dans et autour du cal nouvellement formé, étaient traités avec des fixateurs externes unilatéraux. La minéralisation a montré une courbe typique avec une première pointe de valeur [0,365 +/– 0,196 g/cm 2 (30,9% de la première valeur)] à 4 – 6 semaines après le début de la distraction. Une valeur minimale apparut à la distraction maximale. Dans la période de consolidation la BMD est montèe jusqu’au moment de l’enlèvement du fixateur à 1,020 +/– 0,234 g/cm2 (87%). La minéralisation du cal, mésurée grace à la technique des ?regions of interest (ROIs)?, augmenté plus vite aux ROIs éloignées qu’aux ROIs très proches du fixateur. De la dynamisation du fixateur résulte une vitesse de minéralisation plus homogène. Nous considérons la DEXA comme une méthode précise pour étudier les processus de la minéralisation et du développement du cal pendant la distraction avec un fixateur unilatéral. En tenant compte des limites de la technique, la DEXA – qui nous livre des valeurs quantitatives – nous aide à comprendre ce qui se passe pendant la distraction.
Accepted: 11 July 1996 相似文献
8.
Laparoscopic Cholecystectomy for Acute Cholecystitis: Prospective Trial 总被引:23,自引:0,他引:23
Samuel Eldar Edmond Sabo Ernest Nash Jack Abrahamson Ibrahim Matter 《World journal of surgery》1997,21(5):540-545
p
< 0.00001) and for hydrops (28.5%) and empyema of the gallbladder
(28.5%) (
p
= 0.004). The difference in conversion
between the group with acute necrotizing (gangrenous) cholecystitis and
the two groups with hydrops and empyema of the gallbladder was not
statistically significant (
p
= 0.07). The complication
rates of acute cholecystitis, hydrops, empyema of the gallbladder, and
gangrenous cholecystitis were 9.0%, 9.5%, 14.0%, and 20.0%,
respectively (
p
= NS). Patients with an operative
delay of 96 hours or less from the onset of acute cholecystitis had a
conversion rate of 23%, whereas a delay of more than 96 hours was
associated with a conversion rate of 47% (
p
= 0.022).
The complication rate was 8.5% in the laparoscopic group and 27% in
the converted group (
p
= 0.013). Patients over 65
years of age, with a history of biliary disease, a nonpalpable
gallbladder, WBC count over 13,000/cc, and acute gangrenous
cholecystitis were independently associated with a high LC conversion
rate; male patients, finding large bile stones, serum bilirubin over
0.8 mg/dl, and WBC count over 13,000/cc were independently associated
with a high complication rate following laparoscopic surgery with or
without conversion. Generally, LC can be performed safely for acute
cholecystitis, with acceptably low conversion and complication rates.
Different forms of cholecystitis carry various conversion and
complication rates in selected cases. LC for acute cholecystitis should
be performed within 96 hours of the onset of disease. Predictors of
conversion and complications may be helpful when planning the
laparoscopic approach to acute cholecystitis. 相似文献
9.
10.