全文获取类型
收费全文 | 315篇 |
免费 | 23篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 8篇 |
妇产科学 | 7篇 |
基础医学 | 50篇 |
口腔科学 | 21篇 |
临床医学 | 21篇 |
内科学 | 74篇 |
皮肤病学 | 5篇 |
神经病学 | 14篇 |
特种医学 | 4篇 |
外科学 | 63篇 |
综合类 | 3篇 |
预防医学 | 35篇 |
眼科学 | 3篇 |
药学 | 18篇 |
中国医学 | 1篇 |
肿瘤学 | 10篇 |
出版年
2023年 | 1篇 |
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 6篇 |
2019年 | 4篇 |
2018年 | 7篇 |
2017年 | 9篇 |
2016年 | 11篇 |
2015年 | 6篇 |
2014年 | 8篇 |
2013年 | 11篇 |
2012年 | 14篇 |
2011年 | 27篇 |
2010年 | 17篇 |
2009年 | 13篇 |
2008年 | 22篇 |
2007年 | 31篇 |
2006年 | 30篇 |
2005年 | 23篇 |
2004年 | 19篇 |
2003年 | 22篇 |
2002年 | 15篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 2篇 |
1995年 | 1篇 |
1993年 | 1篇 |
1990年 | 2篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 2篇 |
1980年 | 1篇 |
1976年 | 1篇 |
1973年 | 2篇 |
1971年 | 1篇 |
1969年 | 2篇 |
1968年 | 1篇 |
1964年 | 1篇 |
1962年 | 1篇 |
1961年 | 1篇 |
排序方式: 共有338条查询结果,搜索用时 15 毫秒
1.
Adriana B Campaner Alessandro Scapinelli Ruy O Machado Roberto E Dos Santos Geni W Beznos Tsutomu Aoki 《Gynecological endocrinology》2006,22(7):395-398
We report a case of a prepubertal girl with juvenile primary hypothyroidism presenting as ovarian cysts and precocious puberty. The 7-year-old female was referred to our clinic because of a pelvic/abdominal mass and vaginal bleeding. Besides these findings, on physical examination we noticed the thyroid gland globally increased and the presence of secondary sexual characteristics. Based upon the clinical profile and investigations, the patient was diagnosed with juvenile primary hypothyroidism due to autoimmune thyroiditis. The cysts and precocious puberty resolved spontaneously after the simple replacement of thyroid hormone. It is important to bear in mind hypothyroidism in cases of girls presenting ovarian cysts and precocious puberty in order to avoid unnecessary surgery on the ovaries. 相似文献
2.
Raph Hamers Sander Bontemps Marjan van den Akker Ruy Souza Júlio Penaforte Niels Chavannes 《Primary care respiratory journal》2006,15(5):299-306
AIMS: The developing world is particularly at risk of an increasing health burden due to an increased prevalence of Chronic Obstructive Pulmonary Disease (COPD) secondary to increasing tobacco consumption. However, research is scarce. The objectives of this study were to assess the current competence for diagnosing COPD in primary care in a resource-limited setting in Brazil, and to develop a local patient profile for case-finding. METHODS: 34 general practitioners (GPs) in five areas of northern Brazil recruited adult patients with principal complaints of cough and/or shortness of breath who then had spirometry (n = 142). RESULTS: For the dichotomous variable 'COPD' the degree of agreement between GP diagnosis (n = 64, 18.3%) and spirometric outcome (n = 36, 25.4%) was poor, with Kappa = 0.055 (SE 0.087) and DOR = 1.35. False-positive and false-negative diagnosis proportions were 19.8% and 75%, respectively. Independent risk factors were 'smoking history of more than five pack years' and 'presence of both dyspnoea and cough'. It requires the testing of 2.2 smokers with more than five pack years to detect one patient at risk. CONCLUSIONS: COPD is a common yet underdiagnosed disease in Brazilian primary care. Spirometry improves diagnostic competence and case-finding substantially. If applied in a pre-selected high-risk population, we believe spirometry can be a cost-effective diagnostic tool for case-finding in the resource-limited setting. This study provides important baseline information for effective guideline implementation. 相似文献
3.
4.
Atrial automaticity and atrioventricular conduction in athletes: contribution of autonomic regulation 总被引:2,自引:0,他引:2
Stein R Moraes RS Cavalcanti AV Ferlin EL Zimerman LI Ribeiro JP 《European journal of applied physiology》2000,82(1-2):155-157
Little is known about the sinoatrial automatism and atrioventricular conduction of trained individuals who present a normal
resting electrocardiogram. We used transesophageal atrial stimulation, a minimally invasive technique, to evaluate aerobically
trained athletes (n=10) and sedentary individuals (n=10) with normal resting electrocardiograms, to test the hypothesis that parasympathetic tone, as detected by heart rate variability,
could be associated with changes in sinoatrial automatism and atrioventricular conduction. Corrected sinus node recovery time
tended to be longer in athletes than in sedentary individuals, but this difference did not reach statistical significance.
The Wenckebach point occurred at a lower rate in athletes than in the controls. Over a 24-h period of measurement, the mean
RR interval was longer in the athletes than in the sedentary individuals. The mean square root of successive differences (rMSSD)
tended to be higher in athletes than in controls, but this difference did not reach statistical significance. There was a
moderate correlation (r=0.48, P < 0.05) between the index of atrioventricular conduction, the rate at the Wenckebach point, and the logarithmically transformed
rMSSD. Thus, as a corollary to its effects on the sinus node, where increased parasympathetic tone, decreased sympathetic
tone, and non-autonomic components may contribute to sinus bradycardia, it is possible that athletic training may also induce
intrinsic adaptations in the conduction system, which could contribute to the higher prevalence of atrioventricular conduction
abnormalities observed in athletes.
Accepted: 2 January 2000 相似文献
5.
6.
Juliana Medeiros de Moraes Diego Eterno de Oliveira Mendonça Vânia Beatriz L. Moura Milton Adriano Pelli Oliveira Cristina Lopes Afonso Marina Clare Vinaud Maria Márcia Bachion Ruy de Souza Lino Jr. 《Lasers in medical science》2013,28(4):1169-1176
Third-degree burn wounds are considered severe injuries because they destroy all the skin layers and may affect subcutaneous tissues, fasciae, muscles, and bones. To favor the healing process of the injured tissues, it is very useful to diminish the occurrence of the inflammatory process. The present study was aimed at comparing the effect of different energetic densities of AlGaInP laser on the inflammatory process and in the healing of third-degree burn wounds in Wistar rats. This study was approved by the Ethics Committee, in which 36 adult male rats were selected and suffered the induction of third-degree burn injury. These rats were divided as follows: group 1—control (treated with silver sulfadiazine), group 2—received energy density of 3 J/cm2, and group 3—received energy density of 6 J/cm2. All animals daily received an occlusive bandage with silver sulfadiazine and 8 % papain. The laser therapy was performed alternatively three times a week. The animals were evaluated on the 3rd, 7th, 14th, and 21st days after the initial lesion and euthanized for the macroscopic, histologic, and morphometric analysis. A higher production of collagen was observed at 7 days and a greater re-epithelialization at 21 days in group 3 (6 J/cm2). Furthermore, the latter when compared to the other groups presented macroscopically a better aspect of the scar at 21 days with more granulation tissue and fibrosis. We conclude that the AlGaInP laser used in dosages of 3 and 6 J/cm2 favors the healing of third-degree burn wounds induced in rats. 相似文献
7.
8.
Erwing Fabian Cardozo Dong Ji George Lau Raymond F. Schinazi Guo‐feng Chen Ruy M. Ribeiro Alan S. Perelson 《Journal of viral hepatitis》2020,27(3):261-269
The decay rate of hepatitis C virus (HCV)‐infected cells during therapy has been used to determine the duration of treatment needed to attain a sustained virologic response, but with direct‐acting anti‐virals (DAA), this rate has been difficult to estimate. Here, we show that it is possible to estimate it, by simultaneously analysing the viral load and alanine aminotransferase (ALT) kinetics during combination DAA therapy. We modelled the HCV RNA and ALT serum kinetics in 26 patients with chronic HCV genotype 1b infection, under four different sofosbuvir‐based combination treatments. In all patients, ALT decayed exponentially to a set point in the normal range by 1‐3 weeks after initiation of therapy. The model indicates that the ALT decay rate during the first few weeks after initiation of therapy reflects the death rate of infected cells, with an estimated median half‐life of 2.5 days in this patient population. This information allows independent estimation of the rate of loss of intracellular replication complexes during therapy. Our model also predicts that the final ALT set point is not related to the release of ALT by dying HCV‐infected cells. Using ALT data, one can separately obtain information about the rate of ‘cure’ of HCV‐infected cells versus their rate of death, something not possible when analysing only HCV RNA data. This information can be used to compare the effects of different DAA combinations and to rationally evaluate their anti‐viral effects. 相似文献
9.
10.
Fernanda C. Flores Wing Sin Chiu Ruy C.R. Beck Cristiane B. da Silva M. Begoña Delgado-Charro 《International journal of pharmaceutics》2018,535(1-2):237-244
This work investigated the impact of formulation including in vitro release profile, repeated dosing, and nail poration on the ex vivo nail delivery performance of antifungal formulations. Chitosan coated and uncoated tioconazole-loaded nanocapsules and a nano-based film-forming vehicle were assessed via in vitro release and in vitro permeation tests using an artificial membrane and human nail clippings, respectively. The later involved single and daily dosing experiments with intact and porated nails. Additional experiments with Nile Red-loaded formulations evaluated the depth of penetration of the fluorescent marker into the nail by laser scanning confocal microscopy. The nanocapsule formulations prolonged release of tioconazole for longer than the control solutions and this ability was related to an enhanced nail penetration of the drug. Further, the new film-forming formulation delivered its drug payload more efficiently than a marketed product. Daily dosing of the formulations doubled the amount of drug recovered from the nails. Porating the nails enhanced tioconazole delivery in single dose experiments only. The depth of penetration of Nile Red into the nails clippings ranged between 90–160?μm. This research suggests that ensuring prolonged release of a drug is fundamental to develop efficacious topical nail formulations. 相似文献