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Giovanna Russo-Mancuso Felicia Di Gregorio Enrica Passero Antonella Sciotto Maria Clorinda Mazzarino† Grazia Malaponte† Gino Schilirog 《British journal of haematology》1995,89(2):291-298
Summary. α-interferon (α-IFN) has been used to treat chronic non-A non-B hepatitis in thalassaemic patients with response rates from 45% to 83%. Unfortunately, treatment with α-IFN is associated with side-effects which have a negative effect on the quality of life of the patient. Therefore it would be useful if we could distinguish in advance those patients who would benefit from such therapy from those who would not. In the present study we found that the modification of lymphocyte subsets 20 h after the administration of the first dose of α-IFN revealed that relative numbers of T helper lymphocytes (CD4+ ) increased in three non-responding patients and decreased in five responding patients, whereas those of T suppressor lymphocytes (CD8+ ), and natural killer cells (CD57+ . CD16+ ) decreased in non-responding patients and increased in responding patients. Therefore analysis of the lymphocyte subsets CD4, CD8, CD57 and CD16 before and 20 h after the administration of α-IFN can be used to predict the clinical response to treatment with α-IFN. 相似文献
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Lymphocyte subsets in kala-azar 总被引:2,自引:0,他引:2
A Sciotto G Russo-Mancuso C M Zinna F F Comisi R M Sciannaca G Schiliro 《Annals of allergy》1989,63(4):343-346
We examined lymphocyte subsets in peripheral blood from children with visceral leishmaniasis both in the active stage of the disease and after recovery. At diagnosis, CD2+ and CD4+ cells showed a significant decrease while CD8+ cells were significantly increased when compared with controls; CD4/CD8 ratio was inverted. All of these alterations returned to normal values 3 months after recovery. 相似文献
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Gino Schilir Elena Mirabile Rosario Testa Giovanna Russo-Mancuso Salvatore P. Dibenedetto 《American journal of medical genetics. Part A》1997,69(2):200-206
Sicily, at the center of the Mediterranean, has been the meeting place of Eastern and Western civilizations, and in the Sicilian population the presence of many different alterations in the globin gene clusters can surely be considered testimony of past colonizations. From 1975 to 1994, 100,000 Sicilian subjects were screened by us to monitor the presence of hemoglobin (Hb) structural variants. In this paper we present the data gathered, emphasizing the high incidence (2.5%) of carriers of at least one abnormal Hb, and the great heterogeneity of globin molecular defects on the island. Twenty-six different mutations were identified: the most common occur in the β-globin gene (βS, βc, δβLepore, βG-San José, βO-Arab), but also quite frequent is the mutated allele αJ-Oxford. The chromosome haplotypes associated with some of them were characterized. Two uncommon Hbs, Copenhagen and D Punjab, and some 18 rare variants complete the wide spectrum of structural alterations of globin genes in Sicily. We think they are de novo mutations prevalently. It is not possible to exclude that the presence of a few of them is related to migratory phenomena, particularly from North Africa and East Asia. Numerous thalassemic alleles complete the picture of globin gene mutations in Silicy. Am. J. Med. Genet. 69:200–206, 1997. © 1997 Wiley-Liss, Inc. 相似文献
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Iron Deficiency Anemia as the Only Sign of Infection with<Emphasis Type="Italic">Helicobacter pylori</Emphasis>: A Report of 9 Pediatric Cases 总被引:3,自引:0,他引:3
Russo-Mancuso G Branciforte F Licciardello M La Spina M 《International journal of hematology》2003,78(5):429-431
Recently, an association between Helicobacter pylori (HP) and iron deficiency anemia (IDA) was proposed. We describe 9 pediatric patients with a history of long-standing IDA and HP infection. After HP test results were confirmed to be positive, anti-HP therapy consisting of omeprazole, clarithromycin, and amoxicillin was administered for 2 weeks. The hematologic profile and iron status were assessed before and periodically after the end of the eradication regimen. The eradication of HP was associated with stable normalization of iron stores. HP infection may be involved in cases of IDA of unknown origin, and the eradication of HP is associated with the resolution of anemia. 相似文献
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Colombatti R Perrotta S Masera N Palazzi G Notarangelo LD Pusiol A Bonetto E De Zen L Nocerino A Samperi P Russo-Mancuso G Sainati L 《Vaccine》2011,29(6):1126-1128
During the recent H1N1 pandemic, children with Sickle Cell Disease (SCD) experienced more hospitalizations and more complications than the general pediatric population. We performed a retrospective multicenter survey at 9 Pediatric Haematology-Oncology Units across Italy. H1N1 admission rate was 5.2%, with all admissions occurring before vaccine availability. Length Of Stay (LOS) was 6.06 days (7.85 for Acute Chest Syndrome), longer than in other countries. Vaccination coverage was not homogeneous, ranging from 0 to 99%; several family-related and health-system related barriers in accessing vaccinations were identified that should be ameliorated to improve coverage in this high risk group of children. 相似文献
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