收费全文 | 30777篇 |
免费 | 3470篇 |
国内免费 | 2118篇 |
耳鼻咽喉 | 296篇 |
儿科学 | 358篇 |
妇产科学 | 298篇 |
基础医学 | 2836篇 |
口腔科学 | 882篇 |
临床医学 | 3817篇 |
内科学 | 3911篇 |
皮肤病学 | 283篇 |
神经病学 | 1318篇 |
特种医学 | 1078篇 |
外国民族医学 | 9篇 |
外科学 | 2772篇 |
综合类 | 6478篇 |
现状与发展 | 12篇 |
一般理论 | 6篇 |
预防医学 | 2673篇 |
眼科学 | 649篇 |
药学 | 3779篇 |
55篇 | |
中国医学 | 2823篇 |
肿瘤学 | 2032篇 |
2024年 | 204篇 |
2023年 | 631篇 |
2022年 | 1694篇 |
2021年 | 2116篇 |
2020年 | 1626篇 |
2019年 | 1119篇 |
2018年 | 1166篇 |
2017年 | 1221篇 |
2016年 | 1066篇 |
2015年 | 1557篇 |
2014年 | 1915篇 |
2013年 | 2006篇 |
2012年 | 2715篇 |
2011年 | 2939篇 |
2010年 | 2064篇 |
2009年 | 1675篇 |
2008年 | 1826篇 |
2007年 | 1673篇 |
2006年 | 1494篇 |
2005年 | 1232篇 |
2004年 | 946篇 |
2003年 | 824篇 |
2002年 | 750篇 |
2001年 | 479篇 |
2000年 | 321篇 |
1999年 | 264篇 |
1998年 | 162篇 |
1997年 | 117篇 |
1996年 | 79篇 |
1995年 | 91篇 |
1994年 | 89篇 |
1993年 | 62篇 |
1992年 | 45篇 |
1991年 | 36篇 |
1990年 | 32篇 |
1989年 | 18篇 |
1988年 | 17篇 |
1987年 | 24篇 |
1986年 | 19篇 |
1985年 | 18篇 |
1984年 | 9篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1981年 | 7篇 |
1979年 | 2篇 |
1976年 | 2篇 |
1973年 | 1篇 |
1970年 | 1篇 |
1969年 | 1篇 |
1968年 | 2篇 |
Methods and Results: This case-control association study contained 1673 samples, including 869 ophthalmic patients and 804 controls. Twelve tag SNPs have been selected from the MYP10 and MYP15 loci and genotyped by SNaPshot method. Among 12 SNPs, rs4840437 and rs6989782 in TNKS gene were found significant association with HM. Carriers of rs4840437G allele and rs4840437GG genotype created a low risk of high myopia (P = .036, OR = 0.81, 95%CI = 0.71–0.93; P = .016, OR = 0.73, 95%CI = 0.56–0.96; respectively). Carriers of rs6989782T allele and rs6989782TT+CT genotype also had a decreased risk of high myopia (P = .048, OR = 0.82, 95%CI = 0.71–0.94; P = .006, OR = 0.74, 95%CI = 0.59–0.92; respectively). Other 10 SNPs displaced nonsignificant association with HM. Additionally, the risk haplotype AC and the protective haplotype GT, generated by two SNPs in TNKS, were considerably more likely to be association with HM (for AC, P = .002 and OR = 1.26; for GT, P = .027 and OR = 0.84).
Conclusions: Our results demonstrated that some heritable variants in the TNKS gene are associated with HM in the Han population. The possible functions of TNKS in the development and pathogenesis of hereditary high myopia still require further researches to identify. 相似文献
Background Drug-related problems are mostly preventable or predictable circumstances that may impact on health outcomes. Clinical pharmacy activities such as medication therapy management can identify and solve these problems, with potential to improve medication safety and effectiveness. Objective To evaluate ability of medication therapy management service to detect drug-related problems and prevent adverse drug events. This study also aimed to assess the risk factors for drugrelated problem occurrence. Setting Medical intensive care unit of a public tertiary hospital in Brazil. Methods Patients were evaluated by a clinical pharmacist, who provided medication therapy management service. Detected drug-related problems were categorized according to the Pharmaceutical Care Network Europe methodology and analyzed in multinomial regression to identify risk factors. Main outcome measure Potential risk factors for drug-related problem occurrence. Results The proposed medication therapy management service allowed detection of 170 drug-related problems that had potential to reach patients causing harm and other 50 unavoidable adverse events. Drug-related problems identified were more often associated with antibacterial use, caused by improper combinations or inadequate drug dosage. These problems required interventions that were accepted by the multidisciplinary team, resulting in more than 85% adherence and total problem solving. Main risk factors identified were previous diagnosis of kidney injury (OR?=?8.38), use of midazolam (OR?=?7.96), furosemide (OR?=?5.87) and vancomycin (OR?=?4.82). Conclusion Medication therapy management proved to be an effective method not only for drug-related problem detection, but also for adverse drug event prevention, contributing to improve patient safety.
相似文献