全文获取类型
收费全文 | 38604篇 |
免费 | 2762篇 |
国内免费 | 128篇 |
专业分类
耳鼻咽喉 | 362篇 |
儿科学 | 1176篇 |
妇产科学 | 768篇 |
基础医学 | 5396篇 |
口腔科学 | 1037篇 |
临床医学 | 3922篇 |
内科学 | 8072篇 |
皮肤病学 | 487篇 |
神经病学 | 3919篇 |
特种医学 | 1376篇 |
外国民族医学 | 6篇 |
外科学 | 5334篇 |
综合类 | 416篇 |
一般理论 | 54篇 |
预防医学 | 2767篇 |
眼科学 | 1181篇 |
药学 | 2872篇 |
中国医学 | 59篇 |
肿瘤学 | 2290篇 |
出版年
2022年 | 207篇 |
2021年 | 520篇 |
2020年 | 364篇 |
2019年 | 556篇 |
2018年 | 653篇 |
2017年 | 552篇 |
2016年 | 628篇 |
2015年 | 694篇 |
2014年 | 934篇 |
2013年 | 1531篇 |
2012年 | 2233篇 |
2011年 | 2419篇 |
2010年 | 1340篇 |
2009年 | 1295篇 |
2008年 | 2357篇 |
2007年 | 2571篇 |
2006年 | 2503篇 |
2005年 | 2527篇 |
2004年 | 2382篇 |
2003年 | 2351篇 |
2002年 | 2220篇 |
2001年 | 523篇 |
2000年 | 414篇 |
1999年 | 482篇 |
1998年 | 528篇 |
1997年 | 459篇 |
1996年 | 372篇 |
1995年 | 393篇 |
1994年 | 382篇 |
1993年 | 374篇 |
1992年 | 382篇 |
1991年 | 376篇 |
1990年 | 352篇 |
1989年 | 336篇 |
1988年 | 295篇 |
1987年 | 277篇 |
1986年 | 324篇 |
1985年 | 318篇 |
1984年 | 387篇 |
1983年 | 378篇 |
1982年 | 409篇 |
1981年 | 348篇 |
1980年 | 358篇 |
1979年 | 247篇 |
1978年 | 257篇 |
1977年 | 248篇 |
1976年 | 161篇 |
1975年 | 172篇 |
1974年 | 159篇 |
1973年 | 134篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
Anders Elm Pedersen Esben Gjerløff Wedebye Schmidt Jesper Freddie Sørensen Carsten Faber Boye Schnack Nielsen Kim Holmstrøm Silje Haukali Omland Peter Tougaard Søren Skov Bo Bang 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(7):547-555
TL1A is a TNF‐like cytokine which has been shown to co‐stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is known about expression and induction in psoriasis. Indeed, the pathogenesis in psoriasis is still not fully understood and it is speculated that cytokines other than TNF‐α are important in subsets of patients. Also, for patients with severe disease that are treated with systemic anti‐TNF‐α blockade, novel candidates to be used as disease and response biomarkers are of high interest. Here, we demonstrate TL1A expression in biopsies from psoriatic lesions. Also, we investigated spontaneous and induced TL1A secretion from PBMCs and blood levels from a cohort of psoriasis patients. Here, increased spontaneous secretion from PBMCs was observed as compared to healthy controls and a small subset of patients had highly elevated TL1A in the blood. Interestingly, activation of PBMCs with various cytokines showed a decreased sensitivity for TL1A activation in psoriasis patients compared to healthy controls.TL1A levels in blood and biopsies could not be correlated with disease activity with this patient cohort. Thus, additional large‐scale studies are warranted to investigate TL1A as a biomarker. 相似文献
5.
6.
Margaret H. Lauerman Karen Irizarry Clint Sliker Brandon R. Bruns Ronald Tesoriero Thomas M. Scalea Deborah M. Stein 《Injury》2019,50(1):131-136
Background
Current blunt cerebrovascular injury (BCVI) grading grossly differentiates injury characteristics such as luminal stenosis (LS) and aneurysmal disease. The effect of increasing degree of LS beyond the current BCVI grading scale on stroke formation is unknown.Study Design
BCVI over a 3-year period were retrospectively reviewed. To investigate influence of LS beyond the BCVI grading scale within aneurysmal and non-aneurysmal BCVI, grade 2 BCVI were subdivided into BCVI with ≥ 25% and ≤ 50% LS and BCVI with > 50% and ≤ 99% LS. Grade 3 BCVI were subdivided into BCVI with pseudoaneurysm (PSA) without LS and BCVI with PSA and LS. We hypothesized increased LS beyond the current BCVI grade distinctions would be associated with higher rates of stroke formation.Results
312 BCVI were included, of which 140 were carotid BCVI and 172 vertebral BCVI. Sixteen carotid BCVI underwent endovascular intervention (EI) and 19 suffered a stroke. In carotid BCVI stroke rates increased sequentially with BCVI grade except in grade 3. There was a stroke rate of 12% in grade 1 carotid BCVI, 18% in grade 2, 6% in grade 3, and 31% in grade 4. In subgroup analysis for grade 2 carotid BCVI, BCVI with > 50% and ≤ 99% LS had higher rates of stroke (22% vs. 15%, p?=?0.44) than BCVI with ≥ 25% and ≤ 50% LS. In subgroup analysis of grade 3 carotid BCVI, BCVI with PSA and LS had higher rates of stroke (9% vs. 4%, p?=?0.48) than BCVI with PSA without LS. Higher rates of EI in grade 2 carotid BCVI with > 50% and ≤ 99% LS (22% vs. 5%, p?=?0.14) and grade 3 carotid BCVI with PSA and LS (35% vs. 4%, p?=?0.01) were noted in subgroup analysis.Conclusion
Higher percentage LS beyond the currently used BCVI grading scale has a non-significantly increased rate of stroke in both aneurysmal and non-aneurysmal BCVI. Grade 3 BCVI with PSA and LS seems to be a high-risk subgroup. Use of EI confounds modern measurement of stroke risk in higher LS BCVI. 相似文献7.
8.
9.