全文获取类型
收费全文 | 8766篇 |
免费 | 400篇 |
国内免费 | 92篇 |
专业分类
耳鼻咽喉 | 87篇 |
儿科学 | 261篇 |
妇产科学 | 287篇 |
基础医学 | 1013篇 |
口腔科学 | 188篇 |
临床医学 | 654篇 |
内科学 | 2237篇 |
皮肤病学 | 136篇 |
神经病学 | 554篇 |
特种医学 | 466篇 |
外科学 | 1440篇 |
综合类 | 25篇 |
一般理论 | 1篇 |
预防医学 | 317篇 |
眼科学 | 97篇 |
药学 | 468篇 |
中国医学 | 12篇 |
肿瘤学 | 1015篇 |
出版年
2024年 | 11篇 |
2023年 | 110篇 |
2022年 | 155篇 |
2021年 | 302篇 |
2020年 | 191篇 |
2019年 | 269篇 |
2018年 | 306篇 |
2017年 | 212篇 |
2016年 | 230篇 |
2015年 | 246篇 |
2014年 | 351篇 |
2013年 | 430篇 |
2012年 | 615篇 |
2011年 | 637篇 |
2010年 | 358篇 |
2009年 | 317篇 |
2008年 | 535篇 |
2007年 | 508篇 |
2006年 | 456篇 |
2005年 | 509篇 |
2004年 | 449篇 |
2003年 | 403篇 |
2002年 | 361篇 |
2001年 | 119篇 |
2000年 | 122篇 |
1999年 | 108篇 |
1998年 | 94篇 |
1997年 | 72篇 |
1996年 | 58篇 |
1995年 | 41篇 |
1994年 | 39篇 |
1993年 | 32篇 |
1992年 | 60篇 |
1991年 | 54篇 |
1990年 | 74篇 |
1989年 | 60篇 |
1988年 | 40篇 |
1987年 | 42篇 |
1986年 | 40篇 |
1985年 | 36篇 |
1984年 | 23篇 |
1983年 | 20篇 |
1982年 | 13篇 |
1980年 | 11篇 |
1979年 | 19篇 |
1976年 | 10篇 |
1974年 | 9篇 |
1973年 | 10篇 |
1971年 | 11篇 |
1968年 | 10篇 |
排序方式: 共有9258条查询结果,搜索用时 15 毫秒
1.
2.
Riccardo Torta Carlotta Berra Luca Binaschi Roberto Borio 《Supportive care in cancer》2007,15(5):539-546
Introduction Amisulpride is a substituted benzamide that, at low doses, selectively blocks D2 and D3 presynaptic dopamine receptors, enhancing
dopaminergic transmission in frontal cortex and limbic areas. Many clinical studies versus placebo, tricyclic antidepressants
and selective serotonin reuptake inhibitors showed amisulpride antidepressant effect, supporting its safety and rapid onset
of action. In oncological population, depression is quite frequent and difficult to treat because of the particular sensitivity
of cancer patients to the antidepressants’ side effects.
Goals of work The aims of this study were to evaluate efficacy, safety and tolerability of low doses of amisulpride (50 mg) in oncological,
depressed patients during chemotheraphy.
Materials and methods One hundred six consecutive cancer outpatients with depressive symptoms were treated in a prospective, intention to treat,
4-week study, and were evaluated in single-blind with Montgomery Asberg rating scale for depression (MADRS), clinical global
impression (CGI) and dosage record treatment emergent symptom scale (DOTES) to assess side effects of treatment.
Main results After 4 weeks of treatment, scores of MADRS and CGI significantly improved (p < 0.002; p < 0.001, respectively), with a reduction of depressive symptoms concerning both emotional (such as apparent sadness, reported
sadness, inner tension, etc.) and physical cluster (such as lack of appetite, reduction in weight, tiredness and insomnia)
with good tolerability (only two patients dropped out).
Conclusions This study is the first trial on the use of amisulpride in a cohort of oncological, depressed patients during chemotherapy.
Amisulpride demonstrated high efficacy and safety. Controlled studies are needed to confirm these preliminary data. 相似文献
3.
Rebecca Voltan Arianna Castaldello Egidio Brocca-Cofano Rita De Michele Chiara Triulzi Giuseppe Altavilla Luisa Tondelli Michele Laus Katia Sparnacci Eva Reali Riccardo Gavioli Barbara Ensoli Antonella Caputo 《Vaccine》2009
Cationic block copolymers spontaneously assemble via electrostatic interactions with DNA molecules in aqueous solution giving rise to micellar structures that protect the DNA from enzymatic degradation both in vitro and in vivo. In addition, we have previously shown that they are safe, not immunogenic and greatly increased antigen-specific CTL responses following six intramuscular inoculations of a very low dose (1 μg) of the vaccine DNA as compared to naked DNA. Nevertheless, they failed to elicit detectable humoral responses against the antigen. To gain further insight in the potential application of this technology, here we show that a shorter immunization protocol based on two DNA intramuscular inoculations of 1 μg of DNA delivered by these copolymers and a protein boost elicits in mice broad (both humoral and cellular) and long-lasting responses and increases the antigen-specific Th1-type T cell responses and CTLs as compared to priming with naked DNA. These results indicate that cationic block copolymers represent a promising adjuvant and delivery technology for DNA vaccination strategies aimed at combating intracellular pathogens. 相似文献
4.
Carmem Lúcia Pessoa-Silva Sasi Dharan Stéphane Hugonnet Sylvie Touveneau Klara Posfay-Barbe Riccardo Pfister Didier Pittet 《Infection control and hospital epidemiology》2004,25(3):192-197
OBJECTIVE: To evaluate the dynamics of bacterial contamination of healthcare workers' (HCWs) hands during neonatal care. SETTING: The 20-bed neonatal unit of a large acute care teaching hospital in Geneva, Switzerland. METHODS: Structured observation sessions were conducted. A sequence of care began when the HCW performed hand hygiene and ended when the activity changed or hand hygiene was performed again. Alcohol-based handrub was the standard procedure for hand hygiene. An imprint of the five fingertips of the dominant hand was obtained before and after hand hygiene and at the end of a sequence of care. Regression methods were used to model the final bacterial count according to the type and duration of care and the use of gloves. RESULTS: One hundred forty-nine sequences of care were observed. Commensal skin flora comprised 72.4% of all culture-positive specimens (n = 360). Other microorganisms identified were Enterobacteriaceae (n = 55, 13.8%); Staphylococcus aureus (n = 10, 2.5%); and fungi (n = 7, 1.8%). Skin contact, respiratory care, and diaper change were independently associated with an increased bacterial count; the use of gloves did not fully protect HCWs' hands from bacterial contamination. CONCLUSIONS: These data confirm that hands become progressively contaminated with commensal flora and potential pathogens during neonatal care, and identify activities at higher risk for hand contamination. They also reinforce the need for hand hygiene after a sequence of care, before starting a different task, and after glove removal. 相似文献
5.
We describe a case of Munchausen's syndrome by proxy in a 12 years old child. The administration of glibenclamide by the mother led to severe hypoglycemias in the child, who underwent various instrumental researches and a subtotal pancreatectomy before the final diagnosis could be reached. The diagnosis also was possible with the substantial help of an accurate psychological survey. The case solution, with disappearance of hypoglycemias, was made possible by the removal of the maternal presence settled by the juvenile court. 相似文献
6.
7.
D Macioce S Caruso M Oldani G L Spreafico F Cammelli G Gadola 《La Chirurgia degli Organi di Movimento》1990,75(2):163-169
The authors conducted a clinical and radiographic study on a group of 43 patients with hip arthroprostheses selected from the three-year period from 1984 to 1987, characterized by no immediate postoperative complications, no positional defects on X-ray examination, and with a Renther test greater than 1. Prostheses were cemented, cementless and combined. Scintigraphy was evaluated for areas of subdivision in the proximal end of the femur and acetabulum, making a semi-quantitative comparison of the intensity of captation of each area with that of the skull and sacroiliac synchondrosis. The authors emphasize that this procedure is both reliable and easy for the early determination (pre-clinical and pre-radiographic) of any complications. A scintigraphic examination of the single areas was also capable of revealing the site and entity of prosthetic bone-to-implant interactions. According to the results reported, PCA prostheses seem to be characterized by better biocompatibility. 相似文献
8.
9.
10.
Sir, The comment of Attilio Di Spiezio Sardo et al. was very interesting.They reported the results of their studies on the effects ofintranasal and transdermal 相似文献