全文获取类型
收费全文 | 1214篇 |
免费 | 49篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 57篇 |
妇产科学 | 7篇 |
基础医学 | 100篇 |
口腔科学 | 54篇 |
临床医学 | 84篇 |
内科学 | 319篇 |
皮肤病学 | 7篇 |
神经病学 | 54篇 |
特种医学 | 316篇 |
外科学 | 57篇 |
综合类 | 13篇 |
预防医学 | 87篇 |
眼科学 | 7篇 |
药学 | 62篇 |
中国医学 | 5篇 |
肿瘤学 | 51篇 |
出版年
2023年 | 7篇 |
2022年 | 8篇 |
2021年 | 25篇 |
2020年 | 12篇 |
2019年 | 16篇 |
2018年 | 24篇 |
2017年 | 12篇 |
2016年 | 7篇 |
2015年 | 24篇 |
2014年 | 23篇 |
2013年 | 29篇 |
2012年 | 45篇 |
2011年 | 46篇 |
2010年 | 38篇 |
2009年 | 36篇 |
2008年 | 31篇 |
2007年 | 60篇 |
2006年 | 38篇 |
2005年 | 29篇 |
2004年 | 26篇 |
2003年 | 22篇 |
2002年 | 19篇 |
2001年 | 20篇 |
2000年 | 12篇 |
1999年 | 23篇 |
1998年 | 48篇 |
1997年 | 40篇 |
1996年 | 58篇 |
1995年 | 43篇 |
1994年 | 36篇 |
1993年 | 39篇 |
1992年 | 10篇 |
1991年 | 14篇 |
1990年 | 13篇 |
1989年 | 33篇 |
1988年 | 36篇 |
1987年 | 30篇 |
1986年 | 27篇 |
1985年 | 42篇 |
1984年 | 21篇 |
1983年 | 24篇 |
1982年 | 26篇 |
1981年 | 24篇 |
1980年 | 12篇 |
1979年 | 3篇 |
1978年 | 5篇 |
1977年 | 26篇 |
1976年 | 18篇 |
1975年 | 14篇 |
1967年 | 7篇 |
排序方式: 共有1289条查询结果,搜索用时 15 毫秒
1.
Iclea Rocha Gama Euclides Marinho Trindade-Filho Suzana Lima Oliveira Nassib Bezerra Bueno Isabelle Tenório Melo Cyro Rego Cabral-Junior Elenita M. Barros Jaqueline A. Galvão Wanessa S. Pereira Raphaela C. Ferreira Bruna R. Domingos Terezinha da Rocha Ataide 《Metabolic brain disease》2015,30(1):93-98
2.
3.
4.
Raquel Carreira Ana Duarte Pedro Monteiro Maria Sancha Santos Ana Cristina Rego Catarina R Oliveira Lino M Gon?alves Luís A Providência 《Revista portuguesa de cardiologia》2004,23(11):1447-1455
Ischemia negatively affects mitochondrial function by inducing the mitochondrial permeability transition (MPT). The MPT is triggered by oxidative stress, which occurs in mitochondria during ischemia as a result of diminished antioxidant defenses and increased reactive oxygen species production. It causes mitochondrial dysfunction and can ultimately lead to cell death. Therefore, drugs able to minimize mitochondrial damage induced by ischemia may prove to be clinically effective. We analyzed the effect of carvedilol, a beta-blocker with antioxidant properties, on mitochondrial dysfunction. Carvedilol decreased levels of TBARS (thiobarbituric acid reactive substances), an indicator of oxidative stress, which is consistent with its antioxidant properties. Regarding cell death by apoptosis, although ischemia did increase caspase-8-like activity, there were no changes in caspase-3-like activity, which is activated downstream of caspase-8; this may indicate that the apoptotic cascade is not activated by 60 minutes of ischemia. We conclude that carvedilol protects ischemic mitochondria by preventing oxidative mitochondrial damage, and, by so doing, it may also inhibit the formation of the MPT pore. 相似文献
5.
6.
7.
A randomized controlled trial of electromagnetic therapy in the primary care management of venous leg ulceration 总被引:1,自引:1,他引:0
OBJECTIVE: The aim was to establish the potential efficacy, tolerabilityand side-effect profile of electromagnetic therapy as an adjunctto conventional dressings in the treatment of venous leg ulcers. METHOD: A prospective, randomized, double blind controlled clinicaltrial was carried out in a dedicated leg ulcer clinic basedin one urban general practice. Nineteen patients with leg ulcersof confirmed venous aetiology were assessed. The main outcomemeasures were rate and scale of venous leg ulcer healing, changesin patient-reported pain levels, quality of life, degree ofmobility, side effect profile and acceptability to patientsand staff. RESULTS: Sixty-eight per cent of patients attending this dedicated clinicachieved improvements in the size of their ulcer (4, 21%, healedfully) and in reduced pain levels (P < 0.05) during the trial,despite the chronicity of ulcer histories. Patients treatedwith electromagnetic therapy at 800 Hz were found at day 50to have significantly greater healing (P < 0.05) and paincontrol (P < 0.05) than placebo therapy or treatment with600 Hz. All patients reported improved mobility at the end ofthe study. The electromagnetic therapy was well tolerated bypatients, with no differences between groups in reporting adverseevents, and proved acceptable to staff. CONCLUSION: Despite the small numbers in this pilot study, electromagnetictherapy provided significant gains in the healing of venousleg ulcers and reduction in pain. Keywords. Electromagnetic therapy, RCT, leg ulcers, primary care. 相似文献
8.
9.
10.