全文获取类型
收费全文 | 899篇 |
免费 | 47篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 20篇 |
儿科学 | 13篇 |
妇产科学 | 33篇 |
基础医学 | 122篇 |
口腔科学 | 18篇 |
临床医学 | 71篇 |
内科学 | 281篇 |
皮肤病学 | 8篇 |
神经病学 | 44篇 |
特种医学 | 32篇 |
外国民族医学 | 2篇 |
外科学 | 131篇 |
综合类 | 13篇 |
预防医学 | 37篇 |
眼科学 | 49篇 |
药学 | 24篇 |
肿瘤学 | 52篇 |
出版年
2023年 | 11篇 |
2022年 | 29篇 |
2021年 | 45篇 |
2020年 | 26篇 |
2019年 | 30篇 |
2018年 | 56篇 |
2017年 | 26篇 |
2016年 | 12篇 |
2015年 | 19篇 |
2014年 | 48篇 |
2013年 | 47篇 |
2012年 | 75篇 |
2011年 | 65篇 |
2010年 | 36篇 |
2009年 | 33篇 |
2008年 | 40篇 |
2007年 | 44篇 |
2006年 | 49篇 |
2005年 | 28篇 |
2004年 | 38篇 |
2003年 | 34篇 |
2002年 | 15篇 |
2001年 | 9篇 |
2000年 | 9篇 |
1999年 | 14篇 |
1998年 | 6篇 |
1997年 | 9篇 |
1996年 | 9篇 |
1995年 | 4篇 |
1994年 | 6篇 |
1993年 | 2篇 |
1992年 | 5篇 |
1991年 | 6篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1988年 | 7篇 |
1987年 | 5篇 |
1986年 | 5篇 |
1985年 | 5篇 |
1984年 | 5篇 |
1983年 | 6篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1977年 | 2篇 |
1975年 | 1篇 |
1974年 | 2篇 |
1972年 | 1篇 |
1969年 | 1篇 |
1964年 | 2篇 |
1963年 | 5篇 |
排序方式: 共有950条查询结果,搜索用时 140 毫秒
1.
Steven N Singh X Charlene Tang Bramah N Singh Paul Dorian Domenic J Reda Crystal L Harris Ross D Fletcher Satish C Sharma J Edwin Atwood Alan K Jacobson H Daniel Lewis Becky Lopez Dennis W Raisch Michael D Ezekowitz 《Journal of the American College of Cardiology》2006,48(4):721-730
OBJECTIVES: The purpose of this study was to determine quality of life (QOL) and exercise performance (EP) in patients with persistent atrial fibrillation (AF) converted to sinus rhythm (SR) compared with those remaining in or reverting to AF. BACKGROUND: Restoration of SR in patients with AF improving QOL and EP remains controversial. METHODS: Patients with persistent AF were randomized double-blind to amiodarone, sotalol, or placebo. Those not achieving SR at day 28 were cardioverted and classified into SR or AF groups at 8 weeks (n = 624) and 1 year (n = 556). The QOL (SF-36), symptom checklist (SCL), specific activity scale (SAS), AF severity scale (AFSS), and EP were assessed. RESULTS: Favorable changes were seen in SR patients at 8 weeks in physical functioning (p < 0.001), physical role limitations (p = 0.03), general health (p = 0.002), and vitality (p < 0.001), and at 1 year in general health (p = 0.007) and social functioning (p = 0.02). Changes in the scores for SCL severity (p = 0.01), functional capacity (p = 0.003), and AFSS symptom burden (p < 0.001) at 8 weeks and in SCL severity (p < 0.01) and AF symptom burden (p < 0.001) at 1 year showed significant improvements in SR versus AF. Symptomatic patients were more likely to have improvement. The EP in SR versus AF was greater from baseline to 8 weeks (p = 0.01) and to 1 year (p = 0.02). The EP correlated with physical functioning and functional capacity except in the AF group at 1 year. CONCLUSIONS: In patients with persistent AF, restoration and maintenance of SR was associated with improvements in QOL measures and EP. There was a strong correlation between QOL measures and EP. 相似文献
2.
3.
Reda M. El-S. Hassanine Mohammed O. Al-Jahdali 《Acta parasitologica / Witold Stefański Institute of Parasitology, Warszawa, Poland》2008,53(3):289-295
During June and July of 2007, a total of 130 specimens of the fish Rastrelliger kanagurta Cuvier (Teleostei, Scombridae), ranging between 19–31 cm in total length, were caught in the Red Sea off the coast of Sharm
El-Sheikh, South Sinai, Egypt, and examined for infections by acanthocephalans (65 fish/month). Of this number, 29 (22.30%)
were slightly or heavily parasitized by the acanthocephalan Diplosentis nudus (Harada, 1938) Pichelin et Cribb, 2001 (Cavisomidae); no other helminth parasites were found in the intestine of R. kanagurta. Twenty-nine infrapopulations of D. nudus, ranging from 23–218 individuals were collected from the infected fishes. These infrapopulations were distributed in a well-defined
fundamental niche along the intestine of R. kanagurta, where the distribution of male worms was not random with respect to female worms size and position and suggests that the
male-male competition for access to female may be intense and may select for large males. No correlation between fish size
and infrapopulation size was observed. Correlations between female-to-male sex ratio and infrapopulation size, numbers of
females and their mean lengths, numbers of males and their mean lengths, mean female length and mean male length within infrapopulation
were very strong, and clearly suggest that as the infrapopulation size increased, the number of females and their mean lengths
decreased and the number of males and their mean lengths increased. Combination of these results strongly suggests density-dependent
effects and competition between male worms. The relationship between the mean female length or size and the number of eggs
within its pseudocoel was strongly positive; egg production by female worm significantly decreases as the infrapopulation
size increases, suggesting density-dependent reduction in female worm fecundity. Tendency for the variability in male testes
size was not significant in infrapopulations of D. nudus. All of these results are discussed. 相似文献
4.
5.
Endoglin (CD105) and vascular endothelial growth factor as prognostic markers in colorectal cancer. 总被引:11,自引:0,他引:11
Reda S Saad Yulin L Liu Girija Nathan James Celebrezze David Medich Jan F Silverman 《Modern pathology》2004,17(2):197-203
Endoglin (CD105) has been shown to be a more useful marker to identify proliferating endothelium involved in tumor angiogenesis than panendothelial markers such as CD31. We investigated endoglin and vascular endothelial growth factor expression as possible prognostic markers in colorectal cancer. Surgical specimens from 150 patients with resected colorectal carcinomas were immunostained for endoglin, CD31 and vascular endothelial growth factor. Colorectal carcinoma cases consisted of 50 cases without lymph node metastases, 50 cases with only lymph node metastases and 50 cases with liver metastases (38 cases also had positive lymph nodes). Positively stained microvessels were counted in densely vascular foci (hot spots) at x 400 fields in each specimen. For vascular endothelial growth factor, intensity of staining was scored on a three-tiered scale. Results were correlated with other prognostic parameters. Endoglin demonstrated significantly more proliferating neoplastic microvessels than CD31 (31+/-10 vs 19+/-8/0.15 mm2 field, P<0.001). Low vascular endothelial growth factor expression within tumor cells was seen in 49 (33%) and high expression in 101 cases (67%). There was a positive correlation of endoglin, CD31 counts and vascular endothelial growth factor overexpression with the presence of angiolymphatic invasion and lymph node metastases (P<0.05). Only endoglin counts correlated significantly with liver metastases and positive vascular pedicle lymph nodes (P<0.05), while vascular endothelial growth factor showed significant correlation with the depth of invasion (P<0.01). Endoglin, by staining higher numbers of the proliferating vessels in colon carcinoma, is a more specific and sensitive marker for tumor angiogenesis than the commonly used panendothelial markers. Endoglin staining also showed prognostic significance with positive correlation with angiolymphatic invasion and metastases to lymph nodes and liver. 相似文献
6.
Bitar R Flores O Reverte M López-Novoa JM Macías JF 《International urology and nephrology》2000,32(2):165-169
This study analysed the effect of low doses ofverapamil added to chronic treatment withangiotensin-converting enzyme (ACE)
inhibitors onblood pressure and serum creatinine levels in eightelderly hypertensive patients who had a steadyincrease of
serum creatinine while on ACE inhibitors.The study was performed in eight elderly hypertensivesubjects, five men and three
women (mean age 70 ±2 years; systolic blood pressure 173 ± 4 mmHg; diastolic blood pressure 99 ± 1 mm Hg) andserum creatinine
of 1.60 ± 0.27 mg/dl beforetreatment. During an average of 25 weeks, ACEinhibitors significantly reduced both systolic anddiastolic
blood pressures, but serum creatinine levelswere increased over basal levels (0,68 ± 0,20 mg/dl, p < 0.05). During an average of 10 weeks,the addition of verapamil did not decrease bloodpressure further, but serum creatinine
levels werereduced to baseline. Our study suggests that theaddition of verapamil to ACE inhibitors can reverseACE-induced
increase in creatinine levels in elderlyhypertensive patients in whom this side effect isobserved.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
7.
Corneal esthesiometry and sub-basal nerves morphological changes in herpes simplex virus keratitis/uveitis patients
下载免费PDF全文
![点击此处可从《国际眼科》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Reda Zemaitiene Modesta Rakauskiene Viliija Danileviciene Violeta Use Loresa Kriauciuniene Dalia Zaliuniene 《国际眼科》2019,12(3):407-411
AIM: To describe and compare corneal sensation and morphological changes of sub-basal corneal nerves by in vivo laser scanning confocal microscopy (LSCM) in herpes simplex virus (HSV) keratitis/uveitis and contralateral, clinically unaffected eyes.
METHODS: A prospective clinical study included 30 HSV eyes and 30 contralateral eyes of 30 patients, diagnosed with unilateral HSV keratitis/uveitis. Both eyes underwent a complete ophthalmological examination, Cochet-Bonnet aesthesiometry and LSCM of the central cornea, using the Heidelberg Retina Tomograph III Rostock Cornea Module. After 6mo, the same examination of the HSV affected and contralateral, clinically unaffected eyes was performed.
RESULTS: HSV eyes, as compared to contralateral eyes, demonstrated a significant decrease in mean corneal sensation (3.1±1.6 vs 5.3±0.8 cm), total nerve fibres number (5.7±4.4 vs 15.1±5.4), nerve branches (3.4±3.0 vs 8.4±4.7), main nerve trunks (2.3±1.6 vs 5.8±2.2), and nerve fibres density (7.5±5.6 vs 18.1±5.3 mm/mm2, P<0.05). There was no significant difference between keratitis and uveitis eyes in mean corneal sensation and nerve fibres parameters. After 6mo, corneal sensation and sub-basal nerve fibres parameters were increased significantly, but did not reach the parameters of contralateral, clinically unaffected eyes.
CONCLUSION: Corneal aesthesiometry and LSCM in HSV affected eyes reveals a significant decrease of corneal sensation and sub-basal nerve fibres which recovers at 6mo but does not reach the normal level. 相似文献
8.
Marine Gaudry Pierre-Antoine Barral Arnaud Blanchard Sylvie Palazzolo Sonia Bolomey Virgile Omnes Mariangela De Masi Magali Carcopino-Tusoli Olivier Meyrignac Hervé Rousseau Alexis Jacquier Reda Hassen-Khodja Alessandra Bura-Rivière Jean-Michel Bartoli Stéphanie Gentile Philippe Piquet Laurence Bal 《European journal of vascular and endovascular surgery》2021,61(6):930-937
- Download : Download high-res image (137KB)
- Download : Download full-size image
9.
10.
Kathleen E. Sullivan Hamid Bassiri Ahmed A. Bousfiha Beatriz T. Costa-Carvalho Alexandra F. Freeman David Hagin Yu L. Lau Michail S. Lionakis Ileana Moreira Jorge A. Pinto M. Isabel de Moraes-Pinto Amit Rawat Shereen M. Reda Saul Oswaldo Lugo Reyes Mikko Seppänen Mimi L. K. Tang 《Journal of clinical immunology》2017,37(7):693-694