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Cara E. Morin Lindsay M. Griffin Rebecca S. Beroukhim Pablo Caro-Domínguez Sherwin Chan Jason N. Johnson Juan C. Infante Christopher Z. Lam LaDonna J. Malone Elizabeth R. Tang Michael D. Taylor James C. Wilkinson Prakash M. Masand 《Pediatric blood & cancer》2023,70(Z4):e29955
Cardiac tumors in children are rare and the majority are benign. The most common cardiac tumor in children is rhabdomyoma, usually associated with tuberous sclerosis complex. Other benign cardiac masses include fibromas, myxomas, hemangiomas, and teratomas. Primary malignant cardiac tumors are exceedingly rare, with the most common pathology being soft tissue sarcomas. This paper provides consensus-based imaging recommendations for the evaluation of patients with cardiac tumors at diagnosis and follow-up, including during and after therapy. 相似文献
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Wenya Linda Bi Lakshmi Nayak David M Meredith Joseph Driver Ziming Du Samantha Hoffman Yvonne Li Eudocia Quant Lee Rameen Beroukhim Mikael Rinne Ricardo McFaline-Figueroa Ugonma Chukwueke Christine McCluskey Sarah Gaffey Andrew D Cherniack Jennifer Stefanik Lisa Doherty Christina Taubert Meghan Cifrino Deborah LaFrankie Thomas Graillon Patrick Y Wen Keith L Ligon Ossama Al-Mefty Raymond Y Huang Alona Muzikansky E Antonio Chiocca Sandro Santagata Ian F Dunn David A Reardon 《Neuro-oncology》2022,24(1):101
BackgroundProgrammed death ligand 1 (PD-L1) contributes to tumor immunosuppression and is upregulated in aggressive meningiomas. We performed a phase II study of nivolumab, a programmed death 1 (PD-1) blocking antibody among patients with grade ≥2 meningioma that recurred after surgery and radiation therapy.MethodsTwenty-five patients received nivolumab (240 mg biweekly) until progression, voluntary withdrawal, unacceptable toxicity, or death. Tumor mutational burden (TMB) and quantification of tumor-infiltrating lymphocytes (TIL) were evaluated as potential immunocorrelative biomarkers. Change in neurologic function was prospectively assessed using the Neurologic Assessment in Neuro-Oncology (NANO) scale.ResultsEnrolled patients had multiple recurrences including ≥3 prior surgeries and ≥2 prior courses of radiation in 60% and 72%, respectively. Nivolumab was well tolerated with no unexpected adverse events. Six-month progression-free survival (PFS-6) rate was 42.4% (95% CI: 22.8, 60.7) and the median OS was 30.9 months (95% CI: 17.6, NA). One patient achieved radiographic response (ongoing at 4.5 years). TMB was >10/Mb in 2 of 15 profiled tumors (13.3%). Baseline TIL density was low but increased posttreatment in 3 patients including both patients with elevated TMB. Most patients who achieved PFS-6 maintained neurologic function prior to progression as assessed by NANO.ConclusionNivolumab was well tolerated but failed to improve PFS-6, although a subset of patients appeared to derive benefit. Low levels of TMB and TIL density were typically observed. NANO assessment of neurologic function contributed to outcome assessment. Future studies may consider rationally designed combinatorial regimens. 相似文献
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Mohd S. Sheikh B. Y. Qazi B. Rameen 《Indian journal of otolaryngology and head and neck surgery》1993,45(2):73-77
Otomycosis is a common ear problem in the Khozistan Province of the Southern Iran. A study of 52 patients of otomycosis showed earache and itching are the commenest presenting symptoms of this predominantly unilateral disease. Otoscopy usually shows a greyish while mass in the external auditory canal with canal wall hyperaemia and varying degrees of canal wall oedema. The mass may occasionally be black or brownish-white or yellow in colour. The possible predisposing factors in otomycosis are discussed in this paper. The fungi isolated were Candida (50% of the patients), Aspergillus (19.23%), Pencillium (7.69%) and Mucor (1.92%) Fungi could be seen but not identified in 9.61% of the patients and in 11.53% the slide examination and the culture were negative. Irrespective of the type of fungal infection 1% tolnaftate and 1% clotrimazole solutions were found to be highly effective against otomycosis whereas 2% acetic acid alone or acetic acid in alcohol were almost ineffective. 相似文献
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Extent of resection and overall survival for patients with atypical and malignant meningioma 下载免费PDF全文
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