全文获取类型
收费全文 | 435篇 |
免费 | 34篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 1篇 |
妇产科学 | 4篇 |
基础医学 | 26篇 |
口腔科学 | 1篇 |
临床医学 | 115篇 |
内科学 | 81篇 |
皮肤病学 | 7篇 |
神经病学 | 31篇 |
特种医学 | 2篇 |
外科学 | 42篇 |
综合类 | 2篇 |
一般理论 | 2篇 |
预防医学 | 8篇 |
眼科学 | 7篇 |
药学 | 123篇 |
肿瘤学 | 14篇 |
出版年
2022年 | 4篇 |
2021年 | 8篇 |
2020年 | 5篇 |
2019年 | 10篇 |
2018年 | 18篇 |
2017年 | 12篇 |
2016年 | 9篇 |
2015年 | 9篇 |
2014年 | 16篇 |
2013年 | 16篇 |
2012年 | 31篇 |
2011年 | 24篇 |
2010年 | 19篇 |
2009年 | 21篇 |
2008年 | 27篇 |
2007年 | 24篇 |
2006年 | 20篇 |
2005年 | 20篇 |
2004年 | 16篇 |
2003年 | 9篇 |
2002年 | 15篇 |
2001年 | 12篇 |
2000年 | 13篇 |
1999年 | 14篇 |
1998年 | 4篇 |
1997年 | 1篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 15篇 |
1991年 | 8篇 |
1990年 | 6篇 |
1989年 | 8篇 |
1988年 | 9篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 6篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1976年 | 1篇 |
1974年 | 2篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1970年 | 1篇 |
1966年 | 3篇 |
1965年 | 2篇 |
排序方式: 共有471条查询结果,搜索用时 31 毫秒
1.
2.
3.
S Plescia G Daidone D Raffa M L Bajardi A Caruso V Cutuli M Amico-Roxas 《Il Farmaco; edizione pratica》1992,47(4):465-475
A number of new 3-(isoxazol-5-yl)-quinazolin-4(3H)-ones was prepared and tested, together a few analogues previously obtained, for their analgesic, antipyretic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effects. In the carrageenan rat foot edema model one of the tested compounds showed activity and LD50 comparable to that of ASA, but the ulceration index approximated zero value. 相似文献
4.
Uzan C Cortez A Dufournet C Fauvet R Siffroi JP Daraï E 《Virchows Archiv : an international journal of pathology》2004,445(6):603-609
Endometriosis is subsequent to the ability of endometrial glands to invade normal tissues. Matrix metalloproteinases (MMPs)—enzymes that mediate normal tissue turnover, including endometrial breakdown during menstruation—appear to be involved in this invasive process. Here, we examined the immunohistochemical expression of MMP-2, MMP-3, MMP-11, tissue inhibitor metalloproteinase (TIMP)-1 and TIMP-2 in endometrium from women with (n=9) or without endometriosis (n=18) in comparison with peritoneal (n=20), ovarian (n=20) and colorectal endometriosis (n=20). Women with endometriosis showed decreased endometrial MMP-2 expression compared with women without endometriosis (mean±SD positive cells: 24.3±28.3% and 69.3±12.1%), together with loss of MMP-3 expression (0 versus 17.5%±20.2). MMP-11, TIMP-1 and TIMP-2 expression was similar in the two groups. Endometrial MMP-2, -3 and -11 expression and TIMP-1 and -2 expression were similar in women with endometriosis and in those with peritoneal endometriosis. MMP-2, -3 and -11 expression was higher in colorectal endometriosis than in ovarian and peritoneal endometriosis. TIMP-2 expression was lower in colorectal endometriosis (P=0.0002) and ovarian endometriotic cysts (P=0.003) than in peritoneal endometriosis. TIMP-1 expression did not vary according to the location of endometriotic lesions. These results suggest that MMP-2 and -3 and TIMP-2 may be involved in the pathogenesis of endometriosis. Interestingly, MMP-2 and -3 overexpression was related to the infiltrative nature of endometriotic lesions, with possible sequential expression from peritoneal to colorectal endometriosis. 相似文献
5.
6.
7.
8.
9.
10.