全文获取类型
收费全文 | 307篇 |
免费 | 6篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 19篇 |
妇产科学 | 16篇 |
基础医学 | 9篇 |
口腔科学 | 2篇 |
临床医学 | 82篇 |
内科学 | 66篇 |
皮肤病学 | 6篇 |
神经病学 | 8篇 |
特种医学 | 6篇 |
外科学 | 53篇 |
综合类 | 15篇 |
预防医学 | 19篇 |
药学 | 7篇 |
肿瘤学 | 4篇 |
出版年
2022年 | 2篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 3篇 |
2014年 | 7篇 |
2013年 | 8篇 |
2012年 | 4篇 |
2010年 | 6篇 |
2009年 | 20篇 |
2008年 | 3篇 |
2007年 | 3篇 |
2006年 | 10篇 |
2005年 | 4篇 |
2004年 | 2篇 |
2003年 | 2篇 |
1999年 | 3篇 |
1998年 | 12篇 |
1997年 | 12篇 |
1996年 | 15篇 |
1995年 | 15篇 |
1994年 | 8篇 |
1993年 | 4篇 |
1992年 | 4篇 |
1991年 | 4篇 |
1990年 | 5篇 |
1989年 | 6篇 |
1988年 | 4篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 1篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1974年 | 2篇 |
1968年 | 1篇 |
1965年 | 1篇 |
1964年 | 2篇 |
1960年 | 1篇 |
1959年 | 7篇 |
1958年 | 10篇 |
1957年 | 24篇 |
1956年 | 21篇 |
1955年 | 15篇 |
1954年 | 18篇 |
1949年 | 9篇 |
1948年 | 4篇 |
1946年 | 1篇 |
排序方式: 共有313条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
5.
Peripancreatic lymphoadenopathy and extrahepatic immunological manifestations in chronic hepatitis C 总被引:1,自引:0,他引:1
S. NERI C. M. BRUNO G. D'ANGELO S. RUSSO 《European journal of clinical investigation》1996,26(8):665-667
Abstract. The aim of the study was to determine the role of peripancreatic lymph node swelling in systemic immunological alterations during chronic hepatitis C (HC). The prospective study was carried out as a clinical study in a university hospital. Clinical, haematochemical and ultrasonographic findings in 182 patients were studied. Ultrasonography was performed by the same operator and the findings were evaluated blind without the operator knowing the clinical and haematochemical parameters. Hepatitis B virus (HBV) markers, anti-HCV antibodies. LKMl, cryoglobulinaemia, rheumatoid factor and anti-tissue antibodies were determined. Liver biopsy was carried out in 43 of the 182 patients. One or two pathological peripancreatic lymph nodes (PLNs) were present in 30 of the 182 patients and, of the 30, 28 were anti-HC positive. Only one patient in the non-PLN group was positive for anti-HCV, there being statistical significance ( P <0.0001) between the PLN and non-PLN groups. In HCV-positive patients, extrahepatic immunological manifestations were observed (cryoglobulinaemia; positivity to anti-smooth muscle, antinuclear and antimitochondrial antibodies; positivity to rheumatoid factor and LKMl). In five patients the presence of focal lymphocytic aggregates was detected by biopsy, whereas one patient presented typical ocular lesion of Mikulicz's syndrome. Our results may confirm the marked lymphotropism shown by the HC virus and indicate more complex immune system involvement, especially in view of the coexisting signs of immune system involvement related to the presence of intrahepatic cellular aggregates detected in our study. We believe that the peripancreatic adenopathy in chronic HCV hepatitis is an important diagnostic sign and may indicate an involvement of the C virus in the still unexplained extrahepatic immunological disorders. 相似文献
6.
A phase II study of pegylated liposomal doxorubicin oxaliplatin and cyclophosphamide as second-line treatment in relapsed ovarian carcinoma 总被引:1,自引:0,他引:1
M.R. VALERIO P. TAGLIAFERRI† F. RASPAGLIESI‡ F. FULFARO G. BADALAMENTI C. ARCARA G. CICERO A. RUSSO S. VENUTA† G. GUARNERI§ & N. GEBBIA 《International journal of gynecological cancer》2006,16(S1):79-85
Abstract. Valerio MR, Tagliaferri P, Raspagliesi F, Fulfaro F, Badalamenti G, Arcara C, Cicero G, Russo A, Venuta S, Guarneri G, Gebbia N. A phase II study of pegylated liposomal doxorubicin oxaliplatin and cyclophosphamide as second-line treatment in relapsed ovarian carcinoma. Int J Gynecol Cancer 2006; 16(Suppl. 1): 79–85
We carried out a phase II nonrandomized study to examine the level of activity of oxaliplatin, pegylated liposomal doxorubicin, and cyclophosphamide in a patient population with relapsed ovarian cancer pretreated with platinum derivatives and paclitaxel. Patients received oxaliplatin (85 mg/m2 ), pegylated liposomal doxorubicin (30 mg/m2 ), and cyclophosphamide (750 mg/m2 ). A total of 49 patients (39 assessable for toxicity and response) were enrolled in this trial. Neutropenia grade 3 was observed in six patients (15%) and anemia grade 3 in one patient (0.2%). Fatigue grade 1–2 occurred in 26 patients (66%), nausea/vomiting grade 1 in 23 patients (58%), and alopecia grade 1–2 in 19 patients (48%). Twenty-one (53%) patients experienced grade 1–2 peripheral neuropathy. The overall response rate was 46% (95% CI 23.6–68.7). Median progression-free survival was 28 weeks (range 12–52 weeks) and median survival was 45 weeks (range 26–136+ weeks). The mean duration of response was 34 weeks (range 16–52 weeks). In platinum-resistant and -refractory ovarian cancer patients, the overall response rate was 37% (CI 95% 14.4–60.8) with a progression-free survival of 28 weeks (range 12–52 weeks) and a median survival of 42 weeks (range 28–84 weeks). This combination chemotherapy is generally well tolerated and is an active second-line regimen against ovarian cancer. 相似文献
We carried out a phase II nonrandomized study to examine the level of activity of oxaliplatin, pegylated liposomal doxorubicin, and cyclophosphamide in a patient population with relapsed ovarian cancer pretreated with platinum derivatives and paclitaxel. Patients received oxaliplatin (85 mg/m
7.
Ventricular Tachycardia/Ventricular Fibrillation Ablation in the Setting of Ischemic Heart Disease 总被引:1,自引:0,他引:1
FRANCIS MARCHLINSKI M.D. FERMIN GARCIA M.D. AMIR SIADATAN M.D. WILLIAM SAUER M.D. STUART BELDNER M.D. ERICA ZADO P.A.-C. HENRY HSIA M.D. DAVID LIN M.D. JOSHUA COOPER M.D. RALPH VERDINO M.D. EDWARD GERSTENFELD M.D. SANJAY DIXIT M.D. REA RUSSO M.D. DAVID CALLANS M.D. 《Journal of cardiovascular electrophysiology》2005,16(S1):S59-S70
Recurrent ventricular tachycardia (VT) in the setting of coronary artery disease is frequently a life-threatening electrophysiologic emergency. Even in patients with an implantable defibrillator, recurrent VT is frequently accompanied by repeated and disabling shock therapy. Catheter ablative therapy offers the ability to provide immediate control of recurrent VT. Long-term elimination of VT should be anticipated in most patients. This article reviews the strategies, tools, techniques, and expected outcome for catheter ablation of stable and unstable ventricular arrhythmias in the setting ischemic heart disease. 相似文献
8.
GEMMA PELARGONIO MARIA L. NARDUCCI ELEONORA RUSSO MICHELA CASELLA PASQUALE SANTANGELI ROBERT CANBY AMIN AL‐AHMAD LARRY D. PRICE LUIGI DI BIASE CANDICE J. KWARK MARK HARWOOD FRANCESCO PERNA GIANLUIGI BENCARDINO CAROLINA IERARDI ENRICO M. TRECARICHI ENRICA SANTELLI MARIO TUMBARELLO PRASANT MOHANTY SHANE BAILEY JOHN DAVID BURKHARDT FULVIO BELLOCCI ANDREA NATALE ANTONIO DELLO RUSSO 《Journal of cardiovascular electrophysiology》2012,23(10):1103-1108
Transvenous Lead Extraction . Introduction: As the population ages, the number of elderly patients with implantable cardiac devices referred for transvenous lead extraction will dramatically increase in Western countries. The safety and effectiveness of lead extraction in elderly patients has not been well evaluated. We report the safety and effectiveness of transvenous lead extraction in octogenarians. Methods and Results: From January 2005 to January 2011, we reviewed data from consecutive patients ≥ 80 years referred to our institutions for transvenous lead extraction because of cardiac device infection or lead malfunction. Clinical characteristics, procedural features, and periprocedural major and minor complications were compared between octogenarians and younger patients. Out of 849 patients undergoing lead extraction in the participating institutions during the study period, 150 (18%) patients were octogenarians (mean age 84 years; range 80–96; 64% males). A significantly higher percentage of octogenarians presented with chronic renal failure (55% vs 26%; P < 0.001), history of malignancy (22% vs 6%; P < 0.001), and chronic obstructive pulmonary disease (46% vs 19%; P < 0.001). Complete lead extraction rates were similar in the 2 age groups (97% in octogenarians vs 96% in patients <80 years; P = 0.39). Periprocedural death occurred in 2 (1.3%) patients ≥80 years and in 5 (0.72%) patients <80 years (P = 0.45 for comparison). No differences in terms of other periprocedural major and minor complications were found between the 2 age groups. Conclusion: Despite presenting with a significantly higher rate of comorbidities, transvenous lead extraction can be performed safely and successfully in octogenarians. (J Cardiovasc Electrophysiol, Vol. 23 pp. 1103‐1108, October 2012) 相似文献
9.
Severe Spontaneous Echo Contrast/Auricolar Thrombosis in “Nonvalvular” AF: Value of Thromboembolic Risk Scores
下载免费PDF全文
![点击此处可从《Pacing and clinical electrophysiology : PACE》网站下载免费的PDF全文](/ch/ext_images/free.gif)
GIOSUÈ MASCIOLI M.D. F.E.S.C. ELENA LUCCA M.D. FEDERICA MICHELOTTI M.D. GIUSY ALIOTO M.D. FRANCO SANTORO M.D. GUIDO BELLI M.D. CRISTINA ROTA M.D. OMBRETTA ORNAGO M.D. GIOVANNI SIRIANNI M.D. EMANUELA PULCINI M.D. MATTEO PENNESI M.D. CARLO SAVASTA M.D. ROSARIO RUSSO M.D. ANTONINO PITÌ M.D. 《Pacing and clinical electrophysiology : PACE》2017,40(1):57-62
10.
ABSTRACT. The association of zinc and vitamin A levels was studied in liver of foetuses and infants which were stillborn or died of various causes between the age of 26 weeks of gestation up to 16 weeks post-partum. No correlation between zinc and vitamin A was observed ( r =0.07). Although smaller infants had more hepatic vitamin A than larger infants no significant difference was observed between these groups for liver zinc values. 相似文献