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排序方式: 共有91条查询结果,搜索用时 15 毫秒
1.
Antonella Meloni Daniele De Marchi Vincenzo Positano Maria Giovanna Neri Maurizio Mangione Petra Keilberg Maddalena Lendini Carla Cirotto Alessia Pepe 《Abdominal imaging》2015,40(8):3129-3136
Purpose
We examined different approaches aimed to deal with the signal fluctuation of pancreatic T2* values due to fat infiltration in order to obtain accurate estimates of iron overload.Methods
Pancreatic T2* values were assessed in 20 patients (13 females, 37.24 ± 9.12 years) enrolled in the Myocardial Iron Overload in Thalassemia network without and with the application of fat suppression-FS (T2*-NoFS and T2*-FS). T2* values were assessed in three different ways: (1) from the immediate fit (original T2*); (2) discarding the echoes until the achievement of a good visual concordance between the signal and the model (final_vis T2*); (3) eliminating the echoes until the achievement of a fitting error (known) <5% (final_thres T2*).Results
For the T2*-NoFS sequence the original T2* values were significantly higher than the final_vis T2* values (difference:4.8 ± 6.1 ms; P < 0.0001) and the final_thres T2* values (difference:4.3 ± 6.1 ms; P = 0.006). For the T2*-FS sequence the original T2* values were comparable to final_vis and final_thres T2* values. The original T2*-FS values were significantly different from the original T2*-NoFS values. The final_vis T2*-FS values were comparable to the final_vis T2*-NoFS values and the final_thresh T2*-FS values were comparable to the final_thresh T2*-NoFS values. For both T2*-FS and T2*-NoFS sequences, the final_thres T2* values were not significantly different from the final_vis T2* values and no bias was present.Conclusions
In the clinical practice, an accurate pancreatic iron overload assessment should be done by applying FS and, when needed, by discarding the TEs until the fitting error goes below 5%.2.
3.
Pepe A Lombardi M Takacs I Positano V Panzarella G Picano E 《Journal of magnetic resonance imaging : JMRI》2004,20(3):390-394
PURPOSE: To evaluate the feasibility of assessing coronary vasodilation following exogenous nitrates, using magnetic resonance angiography (MRA). The assessment of coronary response to exogenous nitrovasodilators may have a diagnostic and prognostic impact in patients with coronary artery disease. To date, stress imaging of coronary artery vasomotion has been confined to the catheterization laboratory. MRA is emerging as a noninvasive tool for coronary artery imaging. MATERIALS AND METHODS: Coronary MRA was performed in 20 healthy volunteers (12 males, age = 33 +/- 8). We used spiral spoiled gradient echo (SSGE) sequences for imaging of coronary artery lumen. After the baseline short-axis view of the coronary artery was obtained, sublingual nitroglycerin (NTG) (0.3 mg) was administered. In all subjects, short-axis views of the coronary artery were acquired repetitively (8-10 times) from 1 up to 10 minutes after NTG administration. Measurements were obtained by two independent investigators. RESULTS: Interpretable short-axis view of left anterior descending artery (LAD) was obtained in 15 subjects (75%); in the remaining five subjects the right coronary artery (RCA) was examined. The interobserver variability was 15%, and the intraobserver variability 4%. The NTG-induced maximal vasodilation was 43 +/- 22%. The vasodilator response over time after NTG was maximal on average at 279 +/- 112 seconds, but with substantial heterogeneity. CONCLUSION: Entity and time course of nitrate-induced coronary vasodilation in the left anterior descending and/or RCA can be assessed using MRA with high feasibility and reproducibility. Coronary MRA has potential for dynamic imaging of coronary vasomotion. 相似文献
4.
As demonstrated in a recent survey, hallux limitus and rigidus are often the presenting complaints of our young population. Normal first metatarsophalangeal joint function depends not only on an intact articulation but also sesamoidal mobility and the capacity for the first metatarsal to plantarflex. Whereas acute or chronic microtrauma can impair articular surfaces, first metatarsal plantarflexion can be limited in cases of hypermobility, excessive metatarsal length, immobility of the first metatarsocuneiform joint, or metatarsus primus elevatus. Conservative therapy can be more effective in relieving the symptoms of hallux limitus or rigidus in young patients; however, surgical intervention is often necessary or desirable. The choice of surgical procedure should be based on the etiology of the deformity, as well as the degree of articular degeneration. It is the senior author's opinion that young patients with hallux limitus or rigidus are best served by the performance of cheilectomy with osteotomies designed to create an internal rocker bar mechanism. Procedures designed to shorten or plantarflex the first metatarsal should be reserved for obvious cases of excessive metatarsal length or elevation. 相似文献
5.
6.
Alessia Pepe Antonella Meloni Giuseppe Rossi Liana Cuccia Giuseppe Domenico D’Ascola Michele Santodirocco Paolo Cianciulli Vincenzo Caruso Maria Antonietta Romeo Aldo Filosa Lorella Pitrolo Maria Caterina Putti Angelo Peluso Saveria Campisi Massimiliano Missere Massimo Midiri Letizia Gulino Vincenzo Positano Massimo Lombardi Paolo Ricchi 《Journal of cardiovascular magnetic resonance》2013,15(1):1
Background
Due to the limited data available in literature, the aim of this multi-centre study was to prospectively compare in thalassemia major (TM) patients the efficacy of combined deferiprone (DFP) and deferoxamine (DFO) regimen versus either DFP and DFO in monotherapy by cardiovascular magnetic resonance (CMR) over a follow up of 18 months.Methods
Among the first 1135 TM patients in the MIOT (Myocardial Iron Overload in Thalassemia) network, we evaluated those who had received either combined regimen (DFO + DFP, N=51) or DFP (N=39) and DFO (N=74) monotherapies between the two CMR scans. Iron overload was measured by T2* multiecho technique. Biventricular function parameters were quantitatively evaluated by cine images.Results
The percentage of patients that maintained a normal global heart T2* value was comparable between DFP+DFO versus both monotherapy groups. Among the patients with myocardial iron overload at baseline, the changes in the global heart T2* and in biventricular function were not significantly different in DFP+DFO compared with the DFP group. The improvement in the global heart T2* was significantly higher in the DFP+DFO than the DFO group, without a difference in biventricular function. Among the patients with hepatic iron at baseline, the decrease in liver iron concentration values was significantly higher with combination therapy than with either monotherapy group.Conclusions
In TM patients at the dosages used in the real world, the combined DFP+DFO regimen was more effective in removing cardiac iron than DFO, and was superior in clearing hepatic iron than either DFO or DFP monotherapy. Combined therapy did not show an additional effect on heart function over DFP. 相似文献7.
Milanesi M Martini N Vanello N Positano V Santarelli MF Landini L 《Medical & biological engineering & computing》2008,46(3):251-261
Electrocardiographic (ECG) signals are affected by several kinds of artifacts that may hide vital signs of interest. In this
study we apply independent component analysis (ICA) to isolate motion artifacts. Standard or instantaneous ICA, which is currently
the most addressed ICA model within the context of artifact removal, is compared to two other ICA techniques. The first technique
is a frequency domain approach to convolutive mixture separation. The second is based on temporally constrained ICA, which
enables the estimation of only one component close to a particular reference signal. Performance indexes evaluate ECG complex
enhancement and relevant heart rate errors. Our results show that both convolutive and constrained ICA implementations perform
better than standard ICA, thus opening up a new field of application for these two methods. Moreover, statistical analysis
reveals that constrained ICA and convolutive ICA do not significantly differ concerning heart rate estimation, even though
the latter overcomes the former in ECG morphology recovery. 相似文献
8.
Santarelli MF Positano V Giovannetti G Frijia F Menichetti L Ardenkjaer-Larsen JH De Marchi D Lionetti V Aquaro G Lombardi M Landini L 《NMR in biomedicine》2012,25(7):925-934
MRS of hyperpolarized (13) C-labeled compounds represents a promising technique for in vivo metabolic studies. However, robust quantification and metabolic modeling are still important areas of investigation. In particular, time and spatial resolution constraints may lead to the analysis of MRS signals with low signal-to-noise ratio (SNR). The relationship between SNR and the precision of quantitative analysis for the evaluation of the in vivo kinetic behavior of metabolites is unknown. In this article, this topic is addressed by Monte Carlo simulations, covering the problem of MRS signal model parameter estimation, with strong emphasis on the peak amplitude and kinetic model parameters. The results of Monte Carlo simulation were confirmed by in vivo experiments on medium-sized animals injected with hyperpolarized [1-(13) C]pyruvate. The results of this study may be useful for the establishment of experimental planning and for the optimization of kinetic model estimation as a function of the SNR value. 相似文献
9.
Meloni A Luciani A Positano V De Marchi D Valeri G Restaino G Cracolici E Caruso V Dell'amico MC Favilli B Lombardi M Pepe A 《Journal of magnetic resonance imaging : JMRI》2011,33(2):348-355
Purpose
To evaluate the effectiveness of the single ROI approach for the detection of hepatic iron burden in thalassemia major (TM) patients in respect to a whole liver measurement.Materials and Methods
Five transverse hepatic slices were acquired by a T2* gradient‐echo sequence in 101 TM patients and 20 healthy subjects. The T2* value was calculated in a single region of interest (ROI) defined in the medium‐hepatic slice. Moreover, the T2* value was extracted on each of the eight ROIs defined in the functionally independent segments. The mean hepatic T2* value was calculated.Results
For patients, the mean T2* values over segments VII and VIII were significantly lower. This pattern was substantially preserved in the two groups identified considering the T2* normal cutoff. All segmental T2* values were correlated with the single ROI T2* value. After the application of a correction map based on T2* fluctuations in the healthy subjects, no significant differences were found in the segmental T2* values.Conclusion
Hepatic T2* variations are low and due to artifacts and measurement variability. The single ROI approach can be adopted in the clinical arena, taking care to avoid the susceptibility artifacts, occurring mainly in segments VII and VIII. J. Magn. Reson. Imaging 2011;33:348–355. © 2011 Wiley‐Liss, Inc. 相似文献10.
Multislice multiecho T2* cardiovascular magnetic resonance for detection of the heterogeneous distribution of myocardial iron overload 总被引:3,自引:0,他引:3
Pepe A Positano V Santarelli MF Sorrentino F Cracolici E De Marchi D Maggio A Midiri M Landini L Lombardi M 《Journal of magnetic resonance imaging : JMRI》2006,23(5):662-668
PURPOSE: To assess the tissue iron concentration of the left ventricle (LV) using a multislice, multiecho T2* MR technique and a segmental analysis. MATERIALS AND METHODS: T2* multiecho MRI was performed in 53 thalassemia major patients. Three short-axis views of the LV were obtained and analyzed with custom-written software. The myocardium was automatically segmented into 12 segments. The T2* value on each segment as well as the global T2* value were calculated. Cine dynamic images were also obtained to evaluate biventricular function parameters by quantitative analysis. RESULTS: For the T2* global value, the coefficient of variation (CoV) for intra-/interobserver and interstudy reproducibility was 3.9% (r = 0.98), 5.5% (r = 0.98), and 4.7% (r = 0.99) respectively. Three groups were identified based on analysis of myocardial T2*: homogeneous (21%), heterogeneous (38%), and no myocardial iron overload (41%). The mean serum ferritin, liver iron concentration, and urinary iron excretion were significantly different among the groups. We did not find significant differences among groups in biventricular function. There was a correlation between the global T2* value and the T2* value in the mid-ventricular septum (r = 0.95, P < 0.0001). CONCLUSION: Multislice multiecho T2* MRI provides a noninvasive, fast, reproducible means of assessing myocardial iron distribution. The single measurement of mid-septal T2* correlated well with the global T2* value. 相似文献