Outcome of patients with newly diagnosed primary CNS lymphoma after high-dose methotrexate followed by consolidation whole-brain radiotherapy and cytarabine: an 8-year cohort study

International Journal of Clinical Oncology - Addition of cytarabine to high-dose methotrexate (HD-MTX) chemotherapy improves outcome of primary CNS lymphoma (PCNSL); however, the combination...     

Comparison of Different Types of Static Computer-Guided Implant Surgery in Varying Bone Inclinations

This research aimed to compare the accuracy of dental implant placement among three types of surgical guide: metal sleeve with key handle (Nobel guide, Nobel Biocare, Göteborg, Sweden), metal sleeve without key handle, and non-sleeve without key handle (Dentium full guide kit, Dentium Co., Seoul, Korea) when placing the implant in different bone inclinations. A total of 72 polyurethane bone models were fabricated in different inclinations (0°, 45°, and 60°). The dental implants were placed in bone models following the company’s recommendations. After dental implants were installed, the digital scans were done by an extraoral scanner. The deviations of the dental implant position were evaluated by superimposition between post-implant placement and reference model by using GOM inspect software. The deviation measurement was shown in 5 parameters: angular deviation, 3D deviation at the crest, 3D deviation at the apex, lateral linear deviation, and vertical linear deviation. The data were analyzed using One-way ANOVA and post-hoc tests at a significance level of 0.05. The accuracy of the dental implant position was not significantly influenced by the difference in the surgical guide system (p > 0.05). There were significant differences between placed and planned implant positions in the different inclinations of the bone. A significant difference was found in all parameters of 0° and 60° bone inclinations (p < 0.05). At 0° and 45°, angulated bone showed significant differences except in 3D deviation at the apex. Between 45° and 60° were significant differences only in angular deviation. Within the limitations of this study, the accuracy of implant placement among three types of surgical guides (Non-sleeve without key handle, Metal sleeve without key handle, and Metal sleeve with key handle) from two companies (Dentium and Nobel Biocare) was similar. Hence, the operators can choose the surgical guide system according to their preference. The inclination of bone can influence the angulation of dental implants.     

Prosthetic rehabilitation of an ocular defect with post-enucleation socket syndrome: A case report

Ocular trauma can be caused by road traffic accidents, falls, assaults, or work-related accidents. Enucleation is often indicated after ocular injury or for the treatment of intraocular tumors, severe ocular infections, and painful blind eyes. Rehabilitation of an enucleated socket without an intraocular implant or with an inappropriately sized implant can result in superior sulcus deepening, enophthalmos, ptosis, ectropion, and lower lid laxity, which are collectively known as post-enucleation socket syndrome. This clinical report describes the rehabilitation of post-enucleation socket syndrome with a modified ocular prosthesis. Modifications to the ocular prosthesis were performed to correct the ptosis, superior sulcus deepening, and enophthalmos. The rehabilitation procedure produced satisfactory results.     

Relation between early postoperative deviation and long-term outcome after unilateral lateral rectus recession and medial rectus resection for adult exotropia

AIM: To evaluate the relationship between early postoperative deviation and long-term outcome after unilateral recession and resection surgery for adult exotropia, and to evaluate exotropic shift after surgery. METHODS: This was a retroprospective study involving adult patients with exotropia who underwent unilateral recession and resection surgery and were followed up for at least 2y. The results were evaluated at 2y and the final visit. Factors influencing a successful outcome were analyzed. Early postoperative deviation at 1wk was used to evaluate relationship with long-term outcome. The long-term outcome was classified into 3 groups: successful, acceptable, and poor. Successful outcome was defined as a distance deviation between esodeviation 8 prism diopters (PD) and exodeviation 10 PD. RESULTS: Forty-two patients were enrolled. The mean age at surgery was 26y (range, 15-49y). The median follow-up period was 30mo (range, 24-108mo). Successful outcome was found in 81% of patients at 2y and in 71% at the final visit. Overcorrection at 1wk postoperatively was associated with a successful outcome at 2y. Initial postoperative alignment between orthotropia and esodeviation of 8 PD had the highest chance of a successful outcome (RR=2.2). The mean postoperative exotropic drift was 4.7 PD at the first month and 9.3 PD at 2y. CONCLUSION: Initial postoperative deviation can predict long-term outcome after unilateral recession and resection surgery for adult exotropia. The most desirable outcome at 1wk post-operatively was orthotropia to small esodeviation. Most patients have exotropic drift at a subsequent follow-up, especially in the first month after surgery.