全文获取类型
收费全文 | 2122篇 |
免费 | 105篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 96篇 |
妇产科学 | 41篇 |
基础医学 | 248篇 |
口腔科学 | 59篇 |
临床医学 | 256篇 |
内科学 | 414篇 |
皮肤病学 | 19篇 |
神经病学 | 268篇 |
特种医学 | 137篇 |
外科学 | 236篇 |
综合类 | 28篇 |
一般理论 | 2篇 |
预防医学 | 83篇 |
眼科学 | 17篇 |
药学 | 233篇 |
中国医学 | 1篇 |
肿瘤学 | 92篇 |
出版年
2021年 | 24篇 |
2020年 | 19篇 |
2019年 | 25篇 |
2018年 | 23篇 |
2017年 | 22篇 |
2016年 | 28篇 |
2015年 | 28篇 |
2014年 | 31篇 |
2013年 | 49篇 |
2012年 | 92篇 |
2011年 | 84篇 |
2010年 | 58篇 |
2009年 | 67篇 |
2008年 | 116篇 |
2007年 | 98篇 |
2006年 | 86篇 |
2005年 | 86篇 |
2004年 | 47篇 |
2003年 | 81篇 |
2002年 | 53篇 |
2001年 | 63篇 |
2000年 | 77篇 |
1999年 | 57篇 |
1998年 | 38篇 |
1997年 | 39篇 |
1996年 | 28篇 |
1995年 | 20篇 |
1994年 | 29篇 |
1993年 | 31篇 |
1992年 | 49篇 |
1991年 | 42篇 |
1990年 | 47篇 |
1989年 | 55篇 |
1988年 | 60篇 |
1987年 | 49篇 |
1986年 | 38篇 |
1985年 | 43篇 |
1984年 | 26篇 |
1983年 | 21篇 |
1982年 | 15篇 |
1981年 | 20篇 |
1980年 | 16篇 |
1979年 | 30篇 |
1978年 | 20篇 |
1977年 | 19篇 |
1976年 | 17篇 |
1975年 | 24篇 |
1974年 | 15篇 |
1971年 | 13篇 |
1968年 | 15篇 |
排序方式: 共有2242条查询结果,搜索用时 15 毫秒
1.
Laser-light scattering was used to observe and quantify the dynamics of human blood platelet aggregation in platelet-rich plasma (PRP). Aggregation was performed in a controlled shear environment by placing the PRP in the annular space between a rotating cylindrical rod and a stationary cylindrical tube. The instrument was capable of very sensitive continuous semi-quantitative measurements of chemically-induced microaggregation. As a demonstration of the technique, results are presented for ADP-induced aggregation at doses of 10, 1, and 0.1 microM and collagen-induced aggregation at a dose of 5 micrograms/ml, each at shear rates of 1,000 s-1 and 500 s-1. Extensive aggregation was observed in response to ADP at even the low dose of 0.1 microM, indicating a high sensitivity to microaggregates. The sensitivity of the ultimate size of the ADP-induced aggregates to ADP concentration was shear dependent. The formation of microaggregates by collagen stimulation was shown to be almost immediate, as contrasted with a 10-20 s typical lag when observed turbidometrically. Disaggregation was observed with 1 microM ADP, but this was only partial, as contrasted with the complete recovery of transmittance observed in the turbidometric technique. Electronic particle sizing and counting was employed to semiquantitatively verify the aggregate size distributions found from mathematical conversion of the laser-light scattering data. 相似文献
2.
The clinical and serological findings and computer tomographic (CT) appearances of a case of secondary cerebral amebiasis due to Entamoeba histolytica are presented. The effect of therapy on the neurological symptoms as well as on the CT findings are described in detail. The multiple intracerebral lesions resolved almost completely and the patient survived without any neurological sequelae. 相似文献
3.
A case of obstructive sleep apnoea is reported that was caused by a dermoid cyst of the floor of the mouth and cured by surgery. 相似文献
4.
ALBERTO Q FARIAS LUCIANA L GONÇALVES EDUARDO LR CANÇADO ANTONIO C SEGURO SILVIA B CAMPOS CLARICE P ABRANTES-LEMOS FLAIR J CARRILHO 《Journal of gastroenterology and hepatology》2006,20(1):147-152
Background and Aims: Primary biliary cirrhosis (PBC) might be complicated by osteoporosis, whose etiology remains unknown but seems to be multifactorial. Prevalence rates of 30% to 60% for distal renal tubular acidosis (DRTA) have been reported in PBC patients, generally as incomplete DRTA. Although it is undisputed that a reduced bone mineral density (BMD) is the expected outcome among patients who have been suffering from longstanding chronic metabolic acidosis, it is unclear if incomplete DRTA is also associated with metabolic bone disease in PBC patients. The present study was undertaken to compare the BMD of PBC patients with and without DRTA.
Methods: The BMD of 23 PBC patients (11 with DRTA and 12 without), all with normal clearance of creatinine, was assessed by dual energy radiograph absorptiometry. The diagnosis of DRTA was made if the urine pH was above 5.4 in all samples after the oral acid overload, showing tubular inability to acidify urine in the presence of test-induced systemic metabolic acidosis.
Results: Densitometric signs of osteoporosis were found in 82% of DRTA cases and in 83% of patients without DRTA (difference not significant). There were no significant differences in BMD measurement, T and Z scores of patients with and without DRTA.
Conclusions: The present study could not support a correlation between the presence of DRTA and the bone loss observed in PBC patients. 相似文献
Methods: The BMD of 23 PBC patients (11 with DRTA and 12 without), all with normal clearance of creatinine, was assessed by dual energy radiograph absorptiometry. The diagnosis of DRTA was made if the urine pH was above 5.4 in all samples after the oral acid overload, showing tubular inability to acidify urine in the presence of test-induced systemic metabolic acidosis.
Results: Densitometric signs of osteoporosis were found in 82% of DRTA cases and in 83% of patients without DRTA (difference not significant). There were no significant differences in BMD measurement, T and Z scores of patients with and without DRTA.
Conclusions: The present study could not support a correlation between the presence of DRTA and the bone loss observed in PBC patients. 相似文献
5.
Cooling of hand and forearm muscles by immersion in 15 degrees C cold water for 5 minutes improved the writing performance of patients with writer's cramp. Since abnormal processing of muscle spindle afferent discharges contributes to the pathology of writer's cramp, this effect might result from a reduction in muscle spindle activity by lowering muscle temperature. Cooling is a simple, cheap, and safe procedure, providing temporary relief for patients with writer's cramp. 相似文献
6.
Y J Crow S M Zuberi R McWilliam J L Tolmie A Hollman K Pohl J B Stephenson 《Journal of medical genetics》1998,35(2):94-98
The Coffin-Lowry syndrome is a rare cause of mental retardation recognised by its distinctive facial and digital features. We have observed an unusual, non-epileptic, cataplexy-like phenomenon in three subjects with the syndrome and we speculate that this feature may go unrecognised. We also provide evidence of neuromuscular dysfunction as part of the phenotype by showing abnormalities on muscle ultrasound in four gene carriers. 相似文献
7.
V K Yeragani R Pohl R Balon C Ramesh D Glitz P Weinberg B Merlos 《Neuropsychobiology》1992,26(1-2):27-32
Recently, heart rate (HR) variability has received considerable attention, and a decreased HR variability has been linked to a significant risk of cardiovascular illness. We have previously reported such a decreased variability in panic disorder patients. In this study, we report on HR variability in 12 depressed and 6 panic disorder patients at baseline and 1 and 3 weeks of treatment with imipramine as measured by the standard deviation, mean consecutive difference and the standard deviation of the mean consecutive difference of the R-R intervals in supine, supine deep breathing and standing postures. In all subjects, imipramine (mean dose: 70 mg/day) produced a significant decrease in heart rate variability at week 3 as measured by the above variables. This decrease in HR variability during imipramine treatment is probably due to its anticholinergic effects. 相似文献
8.
This study reports the time of onset of chest pain in 792 consecutive elderly patients admitted to a coronary care unit with myocardial infarction during a 10-year period. Statistical analysis demonstrated a bimodal frequency distribution with peaks in the time of onset of chest pain between 23 h 30 and 00 h 30 and between 06 h 30 and 08 h 30. 相似文献
9.
10.