全文获取类型
收费全文 | 711篇 |
免费 | 41篇 |
国内免费 | 6篇 |
专业分类
儿科学 | 10篇 |
妇产科学 | 10篇 |
基础医学 | 81篇 |
口腔科学 | 4篇 |
临床医学 | 54篇 |
内科学 | 259篇 |
皮肤病学 | 5篇 |
神经病学 | 32篇 |
特种医学 | 28篇 |
外科学 | 78篇 |
综合类 | 3篇 |
预防医学 | 26篇 |
眼科学 | 11篇 |
药学 | 71篇 |
肿瘤学 | 86篇 |
出版年
2023年 | 5篇 |
2022年 | 6篇 |
2021年 | 22篇 |
2020年 | 9篇 |
2019年 | 18篇 |
2018年 | 19篇 |
2017年 | 16篇 |
2016年 | 24篇 |
2015年 | 16篇 |
2014年 | 27篇 |
2013年 | 39篇 |
2012年 | 61篇 |
2011年 | 68篇 |
2010年 | 28篇 |
2009年 | 29篇 |
2008年 | 38篇 |
2007年 | 32篇 |
2006年 | 36篇 |
2005年 | 35篇 |
2004年 | 41篇 |
2003年 | 24篇 |
2002年 | 42篇 |
2001年 | 12篇 |
2000年 | 9篇 |
1999年 | 12篇 |
1998年 | 9篇 |
1997年 | 10篇 |
1996年 | 6篇 |
1995年 | 4篇 |
1994年 | 3篇 |
1993年 | 6篇 |
1992年 | 8篇 |
1991年 | 4篇 |
1990年 | 7篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1987年 | 7篇 |
1986年 | 6篇 |
1985年 | 2篇 |
1984年 | 3篇 |
1982年 | 2篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1975年 | 2篇 |
1973年 | 1篇 |
1971年 | 1篇 |
排序方式: 共有758条查询结果,搜索用时 15 毫秒
1.
2.
J B Piera 《Phlébologie》1987,40(2):365-370
Vascular complications are frequent in paralyzing neurologic disorders, particularly in peripheral neurologic diseases: edema of the declive, cold feet, acrocyanosis, increased sudation. An enlarged leg in a paralyzed subject presenting frequently reduced sensitivity may indicate phlebitis, but also hematoma of an undetected fracture, or osteoarthropathy. Trophic disorders, such as edema, ulcerative hyperkeratosis and subcutaneous hematoma, are sometimes indicative of an unrecognized peripheral neuropathy, notably diabetic. Sclerous complications of venous impairment, or trophic disorders in algesic dystrophy, may result in incorrect diagnosis of a neurologic disorder. In practical therapeutic terms, it is necessary to emphasize the value of elastic retention, attentive pedicure and flexible and shock-absorbing footwear. 相似文献
3.
4.
5.
6.
7.
Ivermectin for the chemotherapy of bancroftian filariasis: a meta-analysis of the effect of single treatment 总被引:4,自引:4,他引:0
Wu-chun Cao Catharina P. B. Van der Ploeg Anton P. Plaisier I. J. Sivera van der Sluijs J. Dik F. Habbema 《Tropical medicine & international health : TM & IH》1997,2(4):393-403
Summary The efficacy and safety of ivermectin in the treatment of filariasis due to Wuchereria bancrofti was assessed by a meta-analysis of the results from 15 published clinical trials. Seven hundred and forty-eight microfilaraemic patients were enrolled in 7 dose-finding and 8 comparative studies. Administered as a single dose, ivermectin induced nearly complete clearance of microfilariae from the blood from the first day to 30 days post-treatment, followed by gradual recurrence of microfilaraemia and increase in its intensity. Higher doses of ivermectin showed greater clearance effects and maintained lower microfilaraemia levels for a longer time. The adverse reactions caused by the drug were flu-like, transient, generally mild and well tolerated by patients. The frequency and intensity of adverse reactions were strongly associated with pretreatment microfilaria counts in the blood, but independent of dose. The findings of the meta-analysis suggest that ivermectin given at a single annual dose of 200 μg/kg body weight or higher, whether or not in combination with DEC, has great potential for therapeutic strategies to control bancroftian filariasis. 相似文献
8.
Di Biase AM Pietrantoni A Tinari A Siciliano R Valenti P Antonini G Seganti L Superti F 《Journal of medical virology》2003,69(4):495-502
Lactoferrin, a member of the transferrin family of approximately 80 kDa, consists of a single polypeptide chain folded in two symmetric, globular lobes (N- and C-lobes), each able to bind one ferric ion. This glycoprotein, found in physiological fluids of mammals, plays an important role in immune regulation and in defense mechanisms against bacteria, fungi, parasites, and viruses. Although the antiviral activity of lactoferrin is one of the major biological functions of such protein, the mechanism of action is still under debate. We have investigated both the role of tryptic fragments of bovine lactoferrin and the mechanism of lactoferrin antiviral effect toward adenovirus infection in HEp-2 cells. The results obtained demonstrated that the anti-adenovirus activity of lactoferrin is mediated by the N-terminal half of the protein as the N-lobe was able to inhibit adenovirus infection, even if at lower extent than undigested lactoferrin, whereas C-lobe was ineffective. The results also showed that the anti-adenovirus action of lactoferrin and of its N-terminal peptide lactoferricin took place on virus attachment to cell membrane, mainly through competition for common glycosaminoglycan receptors. The data provide evidence that the anti-adenovirus activity of lactoferrin is mediated mainly by the cluster of positive charges at the N-terminus of whole molecule and that the N-terminal peptide lactoferricin alone is sufficient to prevent infection. 相似文献
9.