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Porcine Kobuvirus in Piglets, Thailand 总被引:2,自引:0,他引:2
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Thiptara A Atwill ER Kongkaew W Chomel BB 《The American journal of tropical medicine and hygiene》2011,85(1):138-145
Rabies and associated risk factors in dogs, cats and cattle (n = 3,454) in southern Thailand during 1994-2008 were evaluated by using a mixed-effect logistic regression model. Overall prevalence was 48%. In dogs, odds of being rabid were 1.7 times higher in unvaccinated dogs than in vaccinated dogs and two times higher in dogs with bite history than in dogs with no known bite history. Similarly, aggressive dogs were more likely to be rabid than non-aggressive dogs. In cattle, aggression, pharyngeal paralysis, hyperactivity, and depression were clinical signs associated with being rabid. Annual fluctuations of the species-specific prevalence of rabies is suggestive of a positive correlation between canine and either feline (r = 0.60, P = 0.05) or bovine rabies (r = 0.78, P = 0.004). Insufficient vaccination coverage led to maintenance of rabies, which could be easily controlled by increased vaccine coverage and public education. 相似文献
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Simakachorn N Pichaipat V Rithipornpaisarn P Kongkaew C Tongpradit P Varavithya W 《Journal of pediatric gastroenterology and nutrition》2000,30(1):68-72
BACKGROUND: Addition of a medication to the World Health Organization protocol for treatment of acute diarrhea in children is controversial. In this trial, the clinical efficacy of a medication (Lactéol Fort sachets; Laboratoire du Lactéol du Docteur Boucard, Houdan France) containing lyophilized heat-killed Lactobacillus acidophilus LB was assessed as an adjunct to oral rehydration therapy. METHODS: Children aged 3 to 24 months with acute diarrhea and mild or moderate dehydration were enrolled in the study. Children received oral rehydration therapy for the first 4 hours. After this first rehydration phase, undiluted milk formula or breast milk was fed alternately with oral rehydration solution. Children were fed rice gruel as tolerated. They received either one sachet containing 10 billion of lyophilized heat-killed L. acidophilus LB or placebo at admission and at 12-hour intervals for five doses. RESULTS: Seventy-three children (37 L. acidophilus LB, 36 placebo) were enrolled, of whom 40 (17 L. acidophilus LB, 23 placebo) received an antibiotic before inclusion. Rotavirus was identified in approximately 50% of the children in each group. After 24 hours of treatment, the number of rotavirus-positive children with watery stools was significantly lower (p = 0.012) in the L. acidophilus LB group. Mean duration of diarrhea was decreased (p = 0.034) with L. acidophilus LB (43.4 hours) versus placebo (57.0 hours). This decreased duration was particularly marked in children with no antibiotic therapy before inclusion (31.1 hours): 42.9 hours for the L. acidophilus LB group versus 74.0 hours for the placebo group (p = 0.016). CONCLUSIONS: Addition of L. acidophilus LB to oral rehydration therapy was effective in the treatment of children with acute diarrhea by decreasing the duration of diarrhea. 相似文献
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Sequence analysis of porcine kobuvirus VP1 region detected in pigs in Japan and Thailand 总被引:1,自引:0,他引:1
Okitsu S Khamrin P Thongprachum A Hidaka S Kongkaew S Kongkaew A Maneekarn N Mizuguchi M Hayakawa S Ushijima H 《Virus genes》2012,44(2):253-257
Porcine kobuvirus is a new candidate species of the genus Kobuvirus in the family Picornaviridae, and information is still limited. The identification of porcine kobuvirus has been performed by the sequence analyses of
the 3D region of the viruses. Therefore, the purpose of this study was to characterize the molecular properties of VP1 nucleotide
sequences of the porcine kobuviruses isolated from porcine stool samples in Japan during 2009 and Thailand between 2006 and
2008. In addition, previous identification of a unique porcine kobuvirus; Japanese H023/2009/JP, which is a bovine kobuvirus-like
strain based on sequence analysis of the 3D region, was also included in this study. All of the strains were amplified by
the VP1-specific primer pair: the amplicons were subjected to direct sequencing and compared with the VP1 nucleotide sequences
of reference strains. The VP1 sequences of strains from the GenBank database revealed high nucleotide sequence identity at
84.3–100%. On the other hand, the nucleotide identities among the 15 porcine kobuvirus strains analyzed in this study ranged
from 78.8 to 99.8%. The results revealed that diversity of the strains in this study were higher than those of the strains
in previous studies. Furthermore, it was found that the VP1 region of the bovine kobuvirus-like strain, H023/2009/JP, clustered
with nine porcine kobuvirus strains that were isolated in Thailand and Japan. Since this strain was previously found to be
closely related to bovine kobuviruses in the 3D gene region, it may be a natural recombinant. 相似文献
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Chowalit Khumjui Pravit Choomkasien Paron Dekumyoy Teera Kusolsuk Wandee Kongkaew Mutita Chalamaat Jeffrey L. Jones 《Emerging infectious diseases》2008,14(12):1913-1915
In 2006, the Thailand Ministry of Public Health studied 28 patients from a village in northern Thailand. All had myalgia, edema, fever, and gastrointestinal symptoms; most had eaten wild boar. A muscle biopsy specimen from a patient showed nonencapsulated larvae with a cytochrome oxidase I gene sequence of Trichinella papuae. 相似文献
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Napaporn Tananuvat Kanokkan Bumroongkit Chainarong Tocharusa Umnat Mevatee Aphisek Kongkaew Somsanguan Ausayakhun 《International ophthalmology》2017,37(6):1289-1298