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POKORSKI M.; SAKAKIBARA Y.; MASUDA A.; MORIKAWA T.; AHN B.; TAKAISHI S.; PAULEV P.E.; HONDA Y. 《European heart journal》1990,11(7):611-618
The purpose of this study was to evaluate the effect of interruptionof the descending supraspinal sympathetic outflow on heart ratecontrol during exposures to chemical stimuli. We investigatedthe heart rate responses to progressive isocapnic hypoxia andhyperoxic hypercapnia using the rebreathing technique and quantifiedthe relationship between heart rate (HR), oxygen saturation(SaO2), alveolar PCO2 (PACO2), and minute ventilation (VE) in16 chronic tetraplegic subjects with low cervical spinal cordtransection. The HR responses were determined from the linearslopes of HR on SaO2 and HR on PACO2. We found that mean restingheart rate was within normal range; 66 ±3 (SEM) beatsmin1. HR increased as oxygenation fell or CO2 tensionrose. The mean tetraplegic HR/SaO2 was 0.83 ± 0.14 beatsmin1 per 1% fall in SaO2 and that of HR/PACO2 was 0.30± 0.13 beats min1 per mmHG rise in PACO2. TheHR and VE responses to either hypoxia or hypercapnia were relatedin the tetraplegic subjects. We conclude that the stimulatoryHR reponses to chemical stimuli are not suppressed by cervicalspinal cord transection. Thus, the descending sympathetic activitydoes not underlie the HR acceleration by chemical stimuli. 相似文献
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