全文获取类型
收费全文 | 7871篇 |
免费 | 208篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 304篇 |
儿科学 | 288篇 |
妇产科学 | 397篇 |
基础医学 | 528篇 |
口腔科学 | 115篇 |
临床医学 | 445篇 |
内科学 | 1534篇 |
皮肤病学 | 311篇 |
神经病学 | 634篇 |
特种医学 | 508篇 |
外科学 | 1990篇 |
综合类 | 28篇 |
一般理论 | 2篇 |
预防医学 | 281篇 |
眼科学 | 261篇 |
药学 | 161篇 |
中国医学 | 1篇 |
肿瘤学 | 300篇 |
出版年
2018年 | 27篇 |
2017年 | 23篇 |
2016年 | 43篇 |
2015年 | 512篇 |
2014年 | 581篇 |
2013年 | 575篇 |
2012年 | 593篇 |
2011年 | 559篇 |
2010年 | 607篇 |
2009年 | 563篇 |
2008年 | 598篇 |
2007年 | 531篇 |
2006年 | 491篇 |
2005年 | 426篇 |
2004年 | 300篇 |
2003年 | 78篇 |
2002年 | 50篇 |
2001年 | 38篇 |
2000年 | 46篇 |
1999年 | 50篇 |
1998年 | 39篇 |
1997年 | 54篇 |
1996年 | 52篇 |
1995年 | 38篇 |
1994年 | 37篇 |
1993年 | 45篇 |
1992年 | 37篇 |
1991年 | 36篇 |
1990年 | 48篇 |
1989年 | 42篇 |
1988年 | 42篇 |
1987年 | 55篇 |
1986年 | 41篇 |
1985年 | 41篇 |
1984年 | 42篇 |
1983年 | 56篇 |
1982年 | 58篇 |
1981年 | 55篇 |
1980年 | 49篇 |
1979年 | 61篇 |
1978年 | 34篇 |
1977年 | 38篇 |
1976年 | 40篇 |
1975年 | 39篇 |
1974年 | 36篇 |
1973年 | 43篇 |
1972年 | 39篇 |
1971年 | 28篇 |
1970年 | 23篇 |
1968年 | 20篇 |
排序方式: 共有8088条查询结果,搜索用时 15 毫秒
1.
Well‐being,health and fitness of children who use wheelchairs: Feasibility study protocol to develop child‐centred ‘keep‐fit’ exercise interventions
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
2.
3.
4.
Chronic transplant dysfunction is a complex dynamic pathogenic process. Clinically, a decrease in glomerular filtration rate (GFR) becomes apparent leading to chronic renal insufficiency and dialysis or death from cardiovascular events. Chronic transplant dysfunction can develop into a chronic alIograft nephropathy (CAN) as a specific entity with dynamic progression. CAN includes a collection of immunologic and non-immunologic factors, rejection, ischemia time, donor and recipient characteristics and toxicity of calcineurin inhibitors. Despite improvements in immunosuppression, the long-range prognosis of renal allografts has not improved. Whether modern immunosuppressive concepts with reduction or avoidance of calcineurin inhibitors and a therapy based on antimetabolites, such as mycophenolate or mTOR-inhibitors could lead to a prolongation of transplant survival, remains to be seen. 相似文献
5.
6.
7.
8.
Serotonin (5-HT) is a mediator (through 5-HT1P receptors) of slow EPSPs in myenteric ganglia of the small intestine. The effect of 5-HT can be mimicked by elevating cAMP; therefore, we tested the hypothesis that the slow EPSP-like response to 5-HT is cAMP-mediated. Guinea pig gut was enzymatically dissociated; myenteric ganglia remained intact and were collected by filtration. Neurons in the isolated ganglia retained their ability to manifest the slow EPSP-like response to 5-HT. Exposure to 5-HT raised the ganglionic level of cAMP (ED50 0.3 μM). This effect was not antagonized by the 5-HT1P antagonist, N-acetyl-5-hydroxytryptophyl-5-hydroxytryptophan amide (100.0 μM), or mimicked by the 5-HT1P agonist, 5-hydroxyindalpine (10.0 μM). Increases in cAMP were also evoked by the 5-HT1 agonist, 5-carboxyamidotryptamine (10.0 μM), the 5-HT2 agonist, (±)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI; 1.0–10.0 μM), and by the 5-HT4 agonists, renzapride (1.0–10.0 μM) and 5-methoxytryptamine (1.0–10.0 μM); however, neither the 5-HT1/5-HT2 antagonists, spiperone, methysergide, and methiothepin, nor the 5-HT4 antagonist, tropisetron (ICS 205–930; 10.0 μM), were able to inhibit the rise in cAMP evoked by these compounds or by 5-HT (0.1–10.0 μM). The 5-HT-evoked elevation of cAMP was antagonized by ketanserin (10.0 μM), which also blocked the effects of 5-methoxytryptamine and DOI, but not those of renzapride. The effective concentration of DOI, however, was higher than that needed for activation of 5-HT2 receptors, and Northern analysis using a cDNA probe encoding the rat 5-HT2 receptor failed to reveal the presence of 5-HT2 mRNA in myenteric ganglia, although it hybridizes with mRNA of the right size in the guinea pig brain. Compounds that failed to change levels of cAMP or to antagonize the action of 5-HT included 8-hydroxy-di-n-propylamino tetralin, R58639, R88226, and sumatriptan. It is concluded that the receptor responsible for the 5-HT-induced rise in cAMP in ganglia isolated from the guinea pig myenteric plexus is not a known subtype of 5-HT receptor. Since the pharmacology of this novel receptor is different from that of the slow EPSP-like response to 5-HT, the receptor probably does not mediate the slow EPSP. © 1993 Wiley-Liss, Inc. 相似文献
9.
PD Dipl.-Psych. Dr. M. Pfingsten 《Manuelle Medizin》2005,43(2):80-84
In chronic pain syndromes multimodal treatment has proved its efficacy. However, multimodal treatment does not mean randomly combining different interventions in a potpourri of methods. Multimodal treatment must closely follow a well-proved conceptual framework. Those concepts may be well illustrated by therapy of back pain. The most elaborate model for understanding the transition from acute to chronic pain is fear avoidance. Based on this model chronic pain status is understood as a learned consequence, which resulted from patients’ anxious avoidance of body movements. In these cases, treatment of a physical pathology is not the main aim of therapy but rather functional restoration. Those multimodal programs meanwhile have demonstrated their effectiveness. However, good results not only depend on recognition of imperative elements in therapy but also on adhering to essential principles (avoidance of negative anticipation, adequate information with assurance techniques, no training of avoidance, recognition of elements of fear therapy). 相似文献
10.