全文获取类型
收费全文 | 174篇 |
免费 | 13篇 |
国内免费 | 2篇 |
专业分类
妇产科学 | 1篇 |
基础医学 | 3篇 |
口腔科学 | 1篇 |
临床医学 | 7篇 |
内科学 | 124篇 |
特种医学 | 5篇 |
外科学 | 18篇 |
药学 | 3篇 |
肿瘤学 | 27篇 |
出版年
2023年 | 3篇 |
2022年 | 4篇 |
2021年 | 7篇 |
2020年 | 7篇 |
2019年 | 5篇 |
2018年 | 12篇 |
2017年 | 10篇 |
2016年 | 12篇 |
2015年 | 5篇 |
2014年 | 8篇 |
2013年 | 8篇 |
2012年 | 14篇 |
2011年 | 8篇 |
2010年 | 14篇 |
2009年 | 6篇 |
2008年 | 12篇 |
2007年 | 9篇 |
2006年 | 6篇 |
2005年 | 8篇 |
2004年 | 8篇 |
2003年 | 5篇 |
2002年 | 2篇 |
2001年 | 2篇 |
2000年 | 4篇 |
1999年 | 5篇 |
1997年 | 2篇 |
1983年 | 1篇 |
1982年 | 2篇 |
排序方式: 共有189条查询结果,搜索用时 15 毫秒
1.
2.
3.
A novel videoendoscopy system by using autofluorescence and reflectance imaging for diagnosis of esophagogastric cancers 总被引:5,自引:0,他引:5
Uedo N Iishi H Tatsuta M Yamada T Ogiyama H Imanaka K Sugimoto N Higashino K Ishihara R Narahara H Ishiguro S 《Gastrointestinal endoscopy》2005,62(4):521-528
BACKGROUND: Image quality of the prior autofluorescence (AF) imaging systems, including the fiber-optic endoscope, was not feasible for general clinical use. The use of AF image alone resulted in low specificity. The objective of the study was to evaluate the resolution and the sensitivity of the novel videoendoscopy system by using AF and reflectance imaging (AFI) in the diagnosis of early esophagogastric cancers. METHODS: This was a case series study. The setting was a pretreatment examination at a cancer center. Five patients with superficial esophageal cancers (SEC) and 21 patients with 22 early gastric cancers (EGC) were included in the study. The extent of the tumors was diagnosed by white light (WL), AF and chromoendoscopic observations. The main outcome measurement was the diagnostic accuracy of each observation in relation to the histologic mapping as a criterion standard. RESULTS: Two of 5 SECs (40%) were correctly diagnosed in the WL image and all (100%) in the AF image as purple or magenta color in a green background. EGCs in atrophic mucosa were observed as purple or magenta areas in a green background, while diffuse-type EGCs in fundic mucosa were observed as green areas in a purple background. Of the 22 EGCs, diagnostic accuracy of WL, AF, and chromoendoscopic observations were 36%: 95% CI [16%, 56%], 68%: 95% CI [49%, 88%], and 91%: 95% CI [79%, 100%], respectively. AFI could reveal flat or isochromatic extensions that were not detected in the WL images. The limitations of the study were ulcerations or inflammation that caused overdiagnosis in the AF observation. CONCLUSIONS: The resolution of the AFI at present is limited, but the image quality was acceptable. The current system of AFI does not equal to chromoendoscopy in sensitivity but has an advantage over standard WL videoendoscopy. 相似文献
4.
Takeshi Yamashina Ryu Ishihara Noriya Uedo Kengo Nagai Fumi Matsui Natsuko Kawada Takashi Oota Hiromitsu Kanzaki Masao Hanafusa Sachiko Yamamoto Noboru Hanaoka Yoji Takeuchi Koji Higashino Hiroyasu Iishi 《Digestive endoscopy》2012,24(4):220-225
Background and Aim: Limited data are available regarding the use of endoscopic submucosal dissection (ESD) for superficial esophageal cancers ≥50 mm in diameter. The aim of the present study was to investigate the safety and success of ESD for superficial esophageal cancers ≥50 mm. Methods: A total of 39 patients with superficial esophageal squamous cell carcinoma ≥50 mm were treated with ESD at Osaka Medical Center for Cancer and Cardiovascular Diseases between January 2004 and April 2011, and were analyzed in a retrospective study. Results: En bloc resection was achieved in all patients. One mediastinal emphysema without perforation occurred during the procedure. Stricture developed in 11 of 39 patients, requiring a median of five endoscopic balloon dilatation procedures. Thirty‐three clinical epithelial or lamina propria mucosal cancers were treated by ESD with curative intent, of which invasion into the muscularis mucosa or deeper was detected in seven and lymphovascular involvement in three. The en bloc resection rate was 100% with a tumor‐free margin achieved in 92% of lesions. The curative resection and complication rates during ESD were 70% and 2.5%, respectively. Conclusion: ESD achieved a high en bloc resection rate of 92% with a tumor‐free margin. Curative resection rate of ESD in patients with clinical epithelial or lamina propria mucosal cancers was not low at 70%. However, the risk of stricture must be taken into account when considering the use of ESD in lesions ≥50 mm. 相似文献
5.
6.
Rifu Kazuma Sasanuma Hideki Takayama Noriya Nitta Naotaka Ogata Yukiyo Akiyama Iwaki Taniguchi Nobuyuki 《Journal of Medical Ultrasonics》2021,48(2):137-144
Journal of Medical Ultrasonics - We previously reported that acoustic radiation force impulse (ARFI) with concomitant administration of perfluorobutane as an ultrasound contrast agent (UCA)-induced... 相似文献
7.
Fujishiro M Jung HY Goda K Hirasawa K Kakushima N Lee IL Morita Y Oda I Takeuchi M Yamamoto Y Zhou PH Uedo N 《Digestive endoscopy》2012,24(Z1):121-123
Endoscopic submucosal dissection (ESD) was invented in Japan and is now permeating into the rest of the world. Therefore, it is necessary to elucidate the desirable ESD training by knowing the current status of ESD training in Japan. After this, we mainly discussed the following three topics: (i) requirements for preceptees to start ESD training; (ii) requirements for competent endoscopists in ESD; and (iii) requirements for preceptors in the first half of the upper gastrointestinal tract session at the Endoscopic Forum Japan 2011. Additionally, we discussed what Japanese endoscopists can do for further permeation of ESD outside Japan, especially in Asia in the second half. The session was wrapped up by the conclusions that it was absolutely necessary to establish official training courses authorized by the Japan Gastroenterological Endoscopy Society with certification for trainees and trainers and our Japanese endoscopists had a responsibility to spread ESD safely and reliably by collaborating with enthusiastic endoscopists in each country which have different backgrounds in terms of incidences and screening systems of target diseases, accessibility to endoscopy, medical economics, national characters, and so on. 相似文献
8.
Noboru Hanaoka MD Ryu Ishihara MD Yoji Takeuchi MD Motoyuki Suzuki MD Hirokazu Uemura MD Takashi Fujii MD Kunitoshi Yoshino MD Noriya Uedo MD Koji Higashino MD Takashi Ohta MD Hiromitsu Kanzaki MD Masao Hanafusa MD Kengo Nagai MD Fumi Matsui MD Hiroyasu Iishi MD Masaharu Tatsuta MD Yasuhiko Tomita MD 《Head & neck》2013,35(9):1248-1254
9.
Fujii Hiroyuki Tsuji Taisuke Yuba Tatsuya Tanaka Shunya Suga Yoshifumi Matsuyama Aosa Omura Ayaka Shiotsu Shinsuke Takumi Chieko Ono Seiko Horiguchi Masahito Hiraoka Noriya 《Clinical rheumatology》2020,39(11):3171-3175
Clinical Rheumatology - We treated two patients with severe respiratory failure due to coronavirus disease 2019 (COVID-19). Case 1 was a 73-year-old woman, and Case 2 was a 65-year-old-man. Neither... 相似文献
10.
Mariko Harada-Shiba Itaru Takamisawa Kanjiro Miyata Takehiko Ishii Nobuhiro Nishiyama Keiji Itaka Kenji Kangawa Fumiki Yoshihara Yujiro Asada Kinta Hatakeyama Noriya Nagaya Kazunori Kataoka 《Molecular therapy》2009,17(7):1180-1186
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by progressive PAH and right ventricular failure. Despite recent advances in therapeutic approaches using prostanoids, endothelin antagonists, and so on, PAH remains a challenging condition. To develop a novel therapeutic approach, we have established a nonviral gene delivery system of poly(ethylene glycol) (PEG)-based block catiomers, which form a polyplex nanomicelle with a nanoscaled core–shell structure in the presence of DNA. The polyplex nanomicelle from PEG-b-poly{N-[N-(2-aminoethyl)-2-aminoethyl]aspartamide} (PEG-b-P[Asp(DET)]), having ethylenediamine units at the side chain, showed ~100-fold increase in luciferase transgene expression activity in mouse lung via intratracheal administration with a minimal toxicity compared with the polyplex from linear poly(ethylenimine) (LPEI). The transfection activity was highest on day 3 after administration and remained detectable until day 14. PEG-b-P[Asp(DET)] polyplex nanomicelles were formulated with a therapeutic plasmid bearing the human adrenomedullin (AM) gene and intratracheally administered to rats with monocrotaline-induced pulmonary hypertension. The right ventricular pressure significantly decreased 3 days after administration as confirmed by a notable increase of pulmonary human AM mRNA levels. Intratracheal administration of PEG-b-P[Asp-(DET)] polyplex nanomicelles showed remarkable therapeutic efficacy with PAH animal models without compromising biocompatibility. 相似文献