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To evaluate the acute effects of anti-asthmatic drugs in vitro, we examined the modulation of various anti-asthmatic drugs in therapeutic concentrations on PAF-induced human eosinophil chemotaxis. Aminophylline (20 micrograms/ml) and Isoproterenol (10 nM) inhibited PAF (3 X 10(-8) M)-induced eosinophil chemotaxis nearly 30%, whereas no inhibitory effects were observed by Dexamethasone (0.1 microM), Tranilast, Ketotifen or Azelastine. Aminophylline (20 micrograms/ml) also inhibited LTB4 (3 X 10(-8) M)-induced eosinophil chemotaxis nearly 30%, whereas it did not inhibit chemotaxis induced by zymosan (5 mg/ml)-activated serum. These results indicate that anti-asthmatic drugs except for aminophylline and isoproterenol, when used acutely in therapeutic concentrations, have no striking inhibitory effects on PAF-induced eosinophil chemotaxis. These results further suggest the possibility that there are different mechanisms in eosinophil chemotaxis induced by PAF, LTB4 or by C5a. 相似文献
3.
A Novel Approach to Patient Self‐Monitoring of Sonographic Examinations Using a Head‐Mounted Display
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Shintaro Akamoto Seiji Noge Jun Uemura Norikatsu Maeda Minoru Ohshima Hirotaka Kashiwagi Naoki Yamamoto Masao Fujiwara Shinichi Yachida Takehiro Takama Masanobu Hagiike Keiichi Okano Hisashi Usuki Yasuyuki Suzuki 《Surgery today》2013,43(5):580-582
Although extraperitoneal colostomy is often performed to prevent postoperative parastomal hernia formation following an open abdominoperineal resection of lower rectal cancer, it has not been widely employed laparoscopically because of the difficulty associated with the extraperitoneal route. This paper describes a laparoscopic extraperitoneal sigmoid colostomy using the Endo Retract? Maxi instrument. This surgical technique is easy, and helps to prevent the development of parastomal hernias. 相似文献
6.
Candidate selection for quadrant‐based focal ablation through a combination of diffusion‐weighted magnetic resonance imaging and prostate biopsy
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7.
Hagihara Kiyotaka Haraguchi Naotsugu Nishimura Junichi Yasueda Asuka Fujino Shiki Ogino Takayuki Takahashi Hidekazu Miyoshi Norikatsu Uemura Mamoru Matsuda Chu Mizushima Tsunekazu Yamamoto Hirofumi Mori Masaki Doki Yuichiro Eguchi Hidetoshi 《Annals of surgical oncology》2022,29(12):7435-7445
Annals of Surgical Oncology - Colorectal cancer (CRC) is a major cause of cancer-related deaths. Metastasis is enhanced through epithelial-mesenchymal transition (EMT), a process primarily induced... 相似文献
8.
Cardiac output of unanesthetized spontaneously hypertensive rats (SHR) and normotensive control rats (NCR) was measured by an aortic pressure pulse contour method. A catheter was introduced into the aortic arch under ether anesthesia and aortic pressure curves were recorded after the recovery from anesthesia. Stroke volume was calculated by reading required pressure and time data on the tracings and substituting them into a special equation. Cardiac output per min per body weight was not significantly different between SHR and NCR. Arterial pressure and total peripheral resistance were higher in SHR than in NCR. On ganglion blockade with hexamethonium bromide in the conscious state, arterial pressure decreased more markedly in SHR than in NCR. Though arterial pressure was still significantly (P less than 0.05) higher in SHR after blockade, cardiac output was larger in SHR more than to account for the difference in arterial pressure. Total peripheral resistance was lower in SHR than in NCR after blockade. It is concluded that, even in the conscious state as in the anesthetized state, the major contribution to the hypertensive state in SHR is an increase in total peripheral resistance due to an elevation of the sympathetic tone. 相似文献
9.
Masaaki Motoori Masahiko Yano Yasuhiko Tomita Hidenori Takahashi Koji Tanaka Keijiro Sugimura Kentaro Kishi Yoshiyuki Fujiwara Norikatsu Miyoshi Hirofumi Akita Kunihito Goto Shigeru Marubashi Shingo Noura Masayuki Ohue Osamu Ishikawa Masato Sakon 《The Journal of surgical research》2014
Background
Neoadjuvant chemotherapy (NACT) improves the prognosis of patients with esophageal cancer who respond, but it is not effective in nonresponders. Therefore, it is crucial to establish a reliable method of predicting response before initiation of chemotherapy. Hypercoagulability, which is thought to be because of upregulation of tissue factor (TF) in cancer cells, was reported to be associated with chemoresistance. The aim of this study was to investigate the association between TF expression and response to NACT in esophageal cancer.Methods
In 67 patients with advanced esophageal cancer, TF expression in pretreatment biopsy samples was evaluated immunohistochemically and correlated with clinicopathologic factors and response to chemotherapy.Results
TF was expressed by 43.3% of the tumors, but there were no correlations observed with any clinicopathologic parameters examined. Clinical and histologic responses to chemotherapy were significantly worse in TF-positive patients compared with TF-negative patients. Multivariate analysis revealed that TF expression was significantly associated with a poor clinical response (P = 0.0431). TF expression was also independently associated with poor progression-free survival (P = 0.0353).Conclusions
TF expression levels in pretreatment biopsy samples are useful for predicting response to NACT in advanced esophageal cancer. Further studies of mechanisms underlying the relationship between TF expression and chemosensitivity are needed. 相似文献10.
Shinji Tokuyama Hidekazu Takahashi Norikatsu Miyoshi Naotsugu Haraguchi Taishi Hata Chu Matsuda Hirofumi Yamamoto Tsunekazu Mizushima Masaki Mori Yuichiro Doki 《Asian journal of endoscopic surgery》2020,13(2):227-230
A 31‐year‐old man with pain in his thigh was diagnosed with a benign presacral cystic mass. We performed laparoscopic subtotal resection of the cyst utilizing mobilization of a total mesorectal excision procedure used in low anterior resection for rectal cancer. Histopathological findings showed that the cystic lumen of the specimen was lined with pseudostratified columnar ciliated epithelium and had glandular structures and smooth muscle in its wall, leading to a diagnosis of bronchogenic cyst. The postoperative course was uneventful, and as of 6 months after surgery, the patient was doing well with no evidence of recurrence. 相似文献