全文获取类型
收费全文 | 1333篇 |
免费 | 73篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 26篇 |
妇产科学 | 23篇 |
基础医学 | 172篇 |
口腔科学 | 22篇 |
临床医学 | 126篇 |
内科学 | 365篇 |
皮肤病学 | 16篇 |
神经病学 | 75篇 |
特种医学 | 45篇 |
外科学 | 167篇 |
综合类 | 8篇 |
预防医学 | 107篇 |
眼科学 | 53篇 |
药学 | 84篇 |
中国医学 | 6篇 |
肿瘤学 | 106篇 |
出版年
2024年 | 3篇 |
2023年 | 30篇 |
2022年 | 38篇 |
2021年 | 73篇 |
2020年 | 43篇 |
2019年 | 38篇 |
2018年 | 43篇 |
2017年 | 31篇 |
2016年 | 33篇 |
2015年 | 37篇 |
2014年 | 61篇 |
2013年 | 52篇 |
2012年 | 97篇 |
2011年 | 78篇 |
2010年 | 56篇 |
2009年 | 51篇 |
2008年 | 76篇 |
2007年 | 53篇 |
2006年 | 70篇 |
2005年 | 72篇 |
2004年 | 58篇 |
2003年 | 55篇 |
2002年 | 51篇 |
2001年 | 37篇 |
2000年 | 30篇 |
1999年 | 20篇 |
1998年 | 13篇 |
1997年 | 8篇 |
1996年 | 4篇 |
1995年 | 11篇 |
1994年 | 10篇 |
1993年 | 10篇 |
1992年 | 8篇 |
1991年 | 9篇 |
1990年 | 5篇 |
1989年 | 4篇 |
1988年 | 3篇 |
1987年 | 5篇 |
1986年 | 8篇 |
1985年 | 5篇 |
1984年 | 4篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1979年 | 3篇 |
1978年 | 4篇 |
1975年 | 3篇 |
1974年 | 2篇 |
1973年 | 3篇 |
1971年 | 1篇 |
排序方式: 共有1418条查询结果,搜索用时 31 毫秒
1.
Noemi Roman 《Dimensions of critical care nursing》2005,24(6):275-278
The pediatric intensive care unit at a community hospital successfully implemented the use of standardized concentrations. The process included deciding the standardized concentrations, use of titration charts, and integration of smart pump technology. Since the implementation of standardized concentrations, there has been no signal or sentinel events reported. It is safe and efficacious to use standardized concentrations combined with smart pump technology and abandon the use of the rule of 6 in the pediatric population. 相似文献
2.
G Belcaro M R Cesarone P Rohdewald A Ricci E Ippolito M Dugall M Griffin I Ruffini G Acerbi M G Vinciguerra P Bavera A Di Renzo B M Errichi F Cerritelli 《Clinical and applied thrombosis/hemostasis》2004,10(4):373-377
The aim of this study was to evaluate the occurrence of deep venous thrombosis (DVT) and superficial vein thrombosis (SVT) and its prophylaxis with an oral anti-edema and antithrombotic agent (Pycnogenol, Horphag, Research Management SA, Geneva, Switzerland) in long-haul flights, in subjects at moderate to high-risk of DVT and SVT. The study pre-included 244 pre-selected subjects; 211 were included (33 were excluded for several reasons due to logistic problems) and 198 completed the study; 13 subjects were lost for follow-up at the end of the flight, all for non-medical problems (i.e., for difficult connections). All subjects were scanned within 90 minutes before the flight and within 2 hours after disembarking. Subjects were supplemented with 100 mg Pycnogenol per capsule. Treatment subjects received two capsules between 2 and 3 hours before flights with 250 mL of water; two capsules were taken 6 hours later with 250 mL of water and one capsule the next day. The control group received comparable placebo at the same intervals. The flight duration was on average 8 hours and 15 minutes (SD 55 min) (range, 7.45-12.33). In the control group there were five thrombotic events (one DVT and four superficial thromboses) while only nonthrombotic, localized phlebitis was observed in the Pycnogenol group (5.15% vs. no events; p<0.025). The ITT (intention to treat) analysis detects 13 failures in the control group (eight lost to follow up + five thrombotic events) of 105 subjects (12.4%) vs. five failures (4.7%; all lost, no thrombotic events) in the treatment group (p<0.025). No unwanted effects were observed. In conclusion, this study indicates that Pycnogenol treatment was effective in decreasing the number of thrombotic events (DVT and SVT) in moderate-to-high risk subjects, during long-haul flights. 相似文献
3.
Comparison of LCx with other current viral load assays for detecting and quantifying human immunodeficiency virus type 1 RNA in patients infected with the circulating recombinant form A/G (CRF02) 下载免费PDF全文
Amendola A Bordi L Angeletti C Girardi E Ippolito G Capobianchi MR 《Journal of clinical microbiology》2004,42(2):811-815
LCx was compared to other assays in measuring human immunodeficiency virus type 1 (HIV-1) CRF02 viremia. LCx showed significant but low correlation with the other methods. Values of <2.60 log(10) cp/ml were observed in 29.6% of specimens with LCx and in only 14.8% with bDNA and PCR, suggesting suboptimal performance of LCx with CRF02. 相似文献
4.
Tozzi V Balestra P Galgani S Narciso P Sampaolesi A Antinori A Giulianelli M Serraino D Ippolito G 《Journal of acquired immune deficiency syndromes (1999)》2001,28(1):19-27
OBJECTIVES: To describe changes in HIV-associated neurocognitive impairment in patients treated with highly active antiretroviral therapy (HAART) for at least 3 years. METHODS: Prospective, observational study of comprehensive neuropsychologic (NP) testing, neurologic examination, and laboratory measures before HAART and after 6, 15 and 45 months of HAART, on 28 consecutive patients seen in our department since April 1996. RESULTS: At baseline, 16 patients were neurocognitively impaired and 12 were not. Among the 16 impaired patients, 5 patients failed to meet the criteria for impairment after 6 months and 9 patients after both 15 and 45 months of HAART, respectively. Statistically significant improvements ( p < or =.01) were seen in two of six measures exploring the concentration and speed of mental processing, two of three measures exploring mental flexibility, in one of five measures exploring memory, and in two of two measures exploring fine motor functions. Unimpaired study subjects performed better than impaired ones in 10 of 17 measures at baseline, in eight of 17 after 6 months, in six of 17 after 15 months, and in seven of 17 after 45 months of HAART. CONCLUSIONS: During the course of HAART, patients experienced a positive and sustained improvement in their neurocognitive performance. However, the presence of 7 of 16 (43.7%) patients with neurocognitive impairment, and the persistence of statistically significant differences in the neurocognitive performance between impaired and unimpaired patients after more than 3 years of HAART, suggests that ongoing HIV-related neurologic damage can occur even during potent antiretroviral treatment. 相似文献
5.
Balotta C Facchi G Violin M Van Dooren S Cozzi-Lepri A Forbici F Bertoli A Riva C Senese D Caramello P Carnevale G Rizzardini G Cremonini L Monno L Rezza G Perno CF Ippolito G d'Arminio-Monforte A Vandamme AM Moroni M;ICONA Study Group 《Journal of acquired immune deficiency syndromes (1999)》2001,27(5):499-505
6.
Girardi E Sampaolesi A Gentile M Nurra G Ippolito G 《Journal of acquired immune deficiency syndromes (1999)》2000,25(1):71-76
We analyzed trends over time and determinants of late diagnosis of HIV infection among people diagnosed with AIDS in 1986 to 1998 in a tertiary care center in Rome, Italy. Information on the date of a first HIV test was collected prospectively, in addition to data routinely collected for AIDS reporting. Patients with AIDS were defined as "late testers" if the time interval between first positive HIV test result and AIDS diagnosis was < or = 3 months. Overall, 503 people with AIDS of 1977 included in the analysis (25.4%) were late testers. the proportion of late testers decreased from 62.5% in 1986 to 16% in 1995. Thereafter, this proportion increased to 20.5% in 1996, 33.7% in 1997, and 36.6% in 1998. In multivariate analysis, the following variables were significantly associated with late testing: AIDS diagnosis in years 1986 to 1993 or 1997 to 1998 compared with 1995, male gender, age > or = 45 years, men who have sex with men, heterosexual contacts, or having unknown transmission mode compared with intravenous drug users, and being born outside Italy. Since 1996, the overall number of AIDS cases diagnosed at our center began to decrease whereas the number of late-testing AIDS patients did not decrease, resulting in an increasing proportion of late testers during the last 3 years of the study. This findings may reflect the effect of combination antiretroviral therapy in slowing progression to AIDS of HIV-infected persons aware of their status. A relevant number of people still discover their HIV infection late and may therefore miss treatment opportunities. New testing strategies are needed to reach more people who engage in high-risk behaviors, especially those at risk for sexual transmission, and those born outside Italy. 相似文献
7.
A 33-year-old male presented with acute lymphoblastic leukemia (ALL) characterized by translocation (11;19)(q23;p13.3). He received an allogeneic bone marrow transplant from a matched unrelated donor. Two years later his disease relapsed with an isolated intracardiac mass, presenting as right heart failure. He had no evidence of concomitant relapse in the bone marrow. Tumor cytogenetics revealed clonal evolution with the karyotype 46,XY,t(3;16)(q23;p13),t(11;19)(q23;p13.3), the chromosome 16 breakpoint involving the band where the genes for multidrug resistance-associated protein and CREB binding protein are known to reside. To our knowledge, this is the first report of an isolated extramedullary relapse of ALL in the heart. 相似文献
8.
G. Pentimalli C. Tudisco E. Scola P. Farsetti E. Ippolito 《Archives of orthopaedic and trauma surgery》1987,106(4):251-256
Summary Two series of 20 patients each with unicameral bone cysts were compared, one treated before 1975 by curettage and bone grafting and the other treated after 1975 with methylprednisolone acetate (MPA) injections. At follow-up, the majority of patients were at the end of skeletal growth. In the MPA-treated series, the average age of the patients at diagnosis was 9.1 years, whereas the average age at follow-up was 16.7 years. The average follow-up interval was 7 years. The steroid-treated series had better radiographic final results than the surgically treated series, with a lower recurrence rate. The number of MPA injections required to heal the lesion ranged from one to six, with 70% of the patients requiring a maximum of three injections. Steroid injection treatment should be preferred to surgical treatment for the better final results, for the virtual absence of complications, and for the greater simplicity of execution and postoperative care.
Zusammenfassung Von zwei Gruppen von je 20 Patienten, die an prematuren Knochenzysten litten, wurde die eine vor 1975 durch Curettage und Auffüllung mit Knochenspänen behandelt, die andere Gruppe nach 1975 durch intea-zystische Infiltrationen mit Methylprednisolone (MPA) behandelt. Sie wurden lange nach Beendigung der Therapie miteinander verglichen. Das durchschnittliche Alter bei der Diagnose der mit MPA behandelten Patienten war 9,1 Jahre und bei der Kontrolle 16,5 Jahre. Die durchschnittlich verstrichene Zeitspanne vom Ende der Behandlung bis zur darauffolgenden Kontrolle betrug 7,3 Jahre. Die Patienten, die mit MPA behandelt wurden, erzielten bessere Endergebnisse, und es gab weniger Rückfälle bei ihnen als bei der Gruppe, die durch Knochenersatz behandelt wurden. Die Anzahl der durchgeführten Infiltrationen variierte zwischen eins und sechs, bei 70% der Patienten waren drei Infiltrationen ausreichend. Anhand der erzielten Ergebnisse stellen wir fest, daß die Behandlung mit MPA, der besseren Endergebnisse wegen, der chirurgischen Behandlung vozuziehen ist, weil außerdem kaum Komplikationen auftreten und weil die Behandlung selbst sowie die postoperative Therapie sich als einfacher erweist.相似文献
9.
M. Stegagno G. Ippolito F. Costa M. L. Aebischer E. Guzzanti 《European journal of epidemiology》1993,9(4):430-435
A prevalence assessment of HIV infection among parturients was performed in order to estimate the future incidence of pediatric AIDS cases and obtain data on the trend of the infection in Italy.Consecutive whole blood samples from newborns collected on filter paper from all regions of Italy (October-December 1990) for routine metabolic screenings, were anonymously examined for HIV-1 antibodies by an ELISA technique. Positive results were confirmed by Western blot.Among 97,658 blood samples tested, 121 (0.124%, 95% confidence interval Poisson distribution 0.103–0.148) were positive. A high prevalence of HIV infection (> 0.2%) was observed in four regions from North and Central Italy while, in some regions in the South, the seroprevalence was ten times lower. In the Lazio Region, namely in Rome, 5 inner-city hospitals with a particularly high prevalence of HIV infection were identified.Assuming that the prevalence of HIV infection observed in the population in this study may reflect the infection rate in the total population of childbearing women, we estimate that approximately 700 newborn babies were delivered from HIV-positive mothers in Italy during 1990. The identification of high prevalence areas could allow for the development of targeted testing programs to plan and provide adequate counselling and care of HIV-infected women and their infants.U. Angeloni (Roma), I. Antonozzi (Roma), R. Beghini (Verona), S. Carta (Roma), R. Ciannainea (Lecce), L. Chiovato (Tirrenia), V.D. Dainato (Foggia), G.C. Fiorucci (Torino), R. attei (Siena), A. Bracco (Napoli), A. Misserini (Taranto), E. Pasquini (Firenze), S. Piazzi (Bologna), L. Piceni-Sereni (Milano), A. Pignero (Napoli), C. Pintor (Cagliari), G. Pugliese (Potenza), C. Romano (Genova), V. Rossolini (Fano). 相似文献
10.
Sarah Wang Lina Patel Elise A. Sannar Mellad Khoshnood Natalie K. Boyd Lorena Mendez Noemi A. Spinazzi Eileen A. Quinn Michael S. Rafii Jonathan D. Santoro 《American journal of medical genetics. Part A》2023,191(7):1769-1782
Down syndrome regression disorder (DSRD) is a clinical symptom cluster of acute or subacute neurocognitive regression in otherwise health persons with Down syndrome. The objective of this study was to evaluate if adverse childhood experiences (ACEs) were more prevalent in children with DSRD than those with DS alone. A survey-based, cohort-based study was performed. Caregivers of individuals with DSRD with onset of symptoms between age 10 and 30 years and DS alone were administered the ACEs questionnaire via an online REDCap survey. A total of 159 responses were collected after excluding incomplete surveys and those not meeting criteria for DSRD. Individuals with DSRD were not more likely to experience ACEs (p = 0.18, 95% confidence interval [CI]: 0.43–1.17). In those with ACEs prior to the onset of symptoms, the median time prior was 7 months (interquartile range: 5–10). Individuals with DSRD were more likely to report three or more ACEs (52, 33%) compared to those with DS alone (39, 22%) (p = 0.02, 95% CI: 1.08–2.87). Exposure to ACEs were not predictive of response to particular therapeutic interventions although those with multiple ACEs 3 months prior to the onset of symptoms was associated with lower response rates to benzodiazepines and immunotherapy (p = 0.02, 95% CI: −3.64–−1.13). This study provides preliminary data that individuals with DSRD experience ACEs at a similar rate to individuals with only DS alone, although three or more ACEs, often preceding the onset of symptoms, was more prevalent in individuals with DSRD. 相似文献