全文获取类型
收费全文 | 5634篇 |
免费 | 298篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 156篇 |
儿科学 | 156篇 |
妇产科学 | 54篇 |
基础医学 | 770篇 |
口腔科学 | 116篇 |
临床医学 | 337篇 |
内科学 | 1419篇 |
皮肤病学 | 65篇 |
神经病学 | 576篇 |
特种医学 | 123篇 |
外科学 | 898篇 |
综合类 | 18篇 |
预防医学 | 125篇 |
眼科学 | 74篇 |
药学 | 456篇 |
中国医学 | 18篇 |
肿瘤学 | 600篇 |
出版年
2023年 | 32篇 |
2022年 | 79篇 |
2021年 | 138篇 |
2020年 | 60篇 |
2019年 | 99篇 |
2018年 | 114篇 |
2017年 | 98篇 |
2016年 | 85篇 |
2015年 | 103篇 |
2014年 | 129篇 |
2013年 | 142篇 |
2012年 | 269篇 |
2011年 | 295篇 |
2010年 | 160篇 |
2009年 | 141篇 |
2008年 | 286篇 |
2007年 | 297篇 |
2006年 | 272篇 |
2005年 | 289篇 |
2004年 | 272篇 |
2003年 | 271篇 |
2002年 | 284篇 |
2001年 | 167篇 |
2000年 | 184篇 |
1999年 | 159篇 |
1998年 | 99篇 |
1997年 | 64篇 |
1996年 | 74篇 |
1995年 | 54篇 |
1994年 | 56篇 |
1993年 | 53篇 |
1992年 | 115篇 |
1991年 | 82篇 |
1990年 | 96篇 |
1989年 | 115篇 |
1988年 | 95篇 |
1987年 | 83篇 |
1986年 | 77篇 |
1985年 | 68篇 |
1984年 | 48篇 |
1983年 | 32篇 |
1982年 | 24篇 |
1981年 | 24篇 |
1980年 | 32篇 |
1979年 | 38篇 |
1978年 | 24篇 |
1977年 | 26篇 |
1976年 | 17篇 |
1975年 | 19篇 |
1966年 | 15篇 |
排序方式: 共有5961条查询结果,搜索用时 15 毫秒
1.
Nobuaki Yanagisawa Shinichi Abe Hiroko Agematsu Koji Sakiyama Akinobu Usami Yuichi Tamatsu Yoshinobu Ide 《Annals of anatomy》2006,188(4):329-336
To elucidate the effects of teeth on muscle fibers in the tongue during the developmental process, we examined the expression of muscle contractile proteins and the genes for those proteins in normal mice and microphthalmic (mi/mi) mice with impaired tooth eruption. The mice were observed during the growth period, including weaning, which is when feeding movements undergo major changes. Expression of the myosin heavy chain (MyHC)-2a protein, whose contraction speed is relatively slow, disappeared after weaning in normal mice, while it remained in high concentrations even after weaning in mi/mi mice. The presence of MyHC-2a after weaning in mice with no tooth eruption was attributed to a compensation for lack of proper masticatory function and sucking-like movements, as MyHC-2a is necessary for these movements. 相似文献
2.
IgG-maleimide peroxidase, Fab'-maleimide peroxidase, polymer and monomer types of Fab'-periodate peroxidase were prepared from an antibody against rat lipoamide dehydrogenase, a component of the pyruvate dehydrogenase complex which is located in mitochondria. They were examined for immunohistochemical staining of the rat kidney. Fab'-maleimide peroxidase was the best for staining mitochondrial protein. IgG-maleimide peroxidase and the monomer type of Fab'-periodate peroxidase had the same intensity of staining. The polymer type of Fab'-periodate peroxidase could not stain the lipoamide dehydrogenase. 相似文献
3.
4.
5.
Hiroki Hamanaka Nobuaki Maeda Masaharu Noda 《The European journal of neuroscience》1997,9(11):2297-2308
Protein tyrosine phosphatase ζ (PTPζRPTPβ) is a proteoglycan-type receptor-like protein tyrosine phosphatase specifically expressed in the brain. In addition to the transmembrane form (PTPζ-A), the extracellular splice variant (PTPζ-S) occurs as a major soluble chondroitin sulphate proteoglycan in the brain. We prepared antibodies which specifically recognize PTPζ-A and -S, and analysed the carbohydrate structures on the two PTPζ isoforms in the developing chick brain. lmmunoprecipitation experiments using these antibodies revealed that almost all of the keratan sulphate recognized by a monoclonal antibody (5D4) was exclusively bound to PTPζ-A and PTPζ-S. Addition of keratan sulphate to these proteoglycans markedly increased from embryonic day (E) 11, in contrast to the addition of LeX and HNK-1 carbohydrates, which gradually increased during development in accordance with expression of the core proteins, suggesting that keratan sulphate modification plays some specific roles. Moreover, at the early embryonic stage keratan sulphate was observed only in several restricted regions, especially at boundary regions such as the roof plate of the tectum, the zona limitans intrathalamica in the diencephalon, and the mesencephalon-metencephalon boundary. At the mesencephalon-metencephalon boundary, keratan sulphate modification of PTPζ isoforms was specifically observed from E3 to E6 on a ring of cells encircling the neural tube and their radially oriented processes, which were identified as radial glial fibres. This expression pattern of keratan sulphate spatiotemporally corresponded well to the formation of the fovea isthmi, a groove separating the mesencephalon from the metencephalon. These results suggest that carbohydrates including keratan sulphate on PTPζ isoforms play important roles in brain development by modulating the cell-cell and/or cell-substrate interactions mediated by these molecules. 相似文献
6.
M Noguchi T Taniya K Ueno M Yagi R Izumi K Konishi I Miyazaki 《The Japanese journal of surgery》1990,20(4):448-452
We report herein a rare case of a 26 year old woman with pheochromocytoma complicated by paralytic ileus. She presented with remarkable abdominal distension and respiratory difficulty but was effectively treated by surgical removal of the tumor with preoperative and operative management using alpha and beta adrenergic blocking agents. An excessive and persistent catecholamine production from large tumors or massive metastases characterizes this rare complication, and a review of the English and Japanese literature is given following this report. 相似文献
7.
8.
The study of the autopsies of six patients with progressive esophageal cancer to investigate complications caused by esophageal stents] 总被引:2,自引:0,他引:2
Yuya Nakamura Masaho Ota Yosuke Izumi Nobuaki Funada 《Nihon Shokakibyo Gakkai zasshi》2006,103(7):812-818
Endoscopic placement of metal stents are used widely for patients with esophageal obstruction and fistula due to progressive esophageal cancer, but cause high rate of severe complications associated with the immediate causes of death. To determine severe complications caused by stents, we studied clinical data and autopsy of six patients who had been treated with stents for inoperable progressive esophageal cancer. Occording to the clinical records only two patients had severe complications due to stents. But at autopsy, three patients had massive hemorrhage in the stent placement, one patient had mediastinitis, and one patient were in imminent danger of perforation whose stent had been incorporated into the adventitia of the wall. More severe complications were revealed than those expected clinically. Endoscopic placement of metal stents have a great deal for the improvement of quality of life. But we should carefully decide the indication because endoscopic placement of metal stents could cause severe complications associated with the immediate causes of death. 相似文献
9.
K Imura A Okada Y Fukui H Kawahara M Yagi A Kubota S Kanaya S Kamata Y Nagata 《JPEN. Journal of parenteral and enteral nutrition》1988,12(5):496-504
In 97 neonates receiving total parenteral nutrition in the postoperative period, clinical assessment was made for a newly devised amino acid solution (PF-I-III) from the standpoint of plasma amino acid profile and nutritional effect. These amino acid solutions prepared are characterized by the high concentration of branched-chain amino acids up to 40%, increased arginine and decreased glycine, phenylalanine and methionine as compared with commercially available solutions. In the PF group, each amino acid was kept within the range of standard value. Correlation between plasma amino acid profiles and the dose of each amino acid administered was obtained, from which minimum, standard, and maximum doses for each amino acid was determined. Based on these values, we proposed new formula for neonates which elicits no abnormal plasma amino acid pattern even when amino acids are administered at the dosage level of 1.5-2.5 g/kg/day. 相似文献
10.
Nobuaki Miyazono M.D. Hiroki Inoue Akira Hori Ichiroh Kanetsuki Jurio Shimada Masayuki Nakajo 《Cardiovascular and interventional radiology》1994,17(1):36-37
We present a 44-year-old woman in whom a bronchialto-coronary artery communication via the conus branch was discovered after distal bronchial artery embolization with gelatin sponge for hemoptysis. If this bronchial-to-coronary artery anastomosis, not visible prior to embolization, had been inadvertently embolized, the patient could have developed a myocardial infarction. To reduce the likelihood of a serious complication, the possibility of this anastomosis should be kept in mind and angiography should be repeated before attempting proximal bronchial artery embolization. 相似文献