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Norbert G. Schwarz Mirko Girmann Njary Randriamampionona Alexandra Bialonski Deborah Maus Anne Caroline Krefis Christine Njarasoa Jeanne Fleury Rajanalison Herly Daniel Ramandrisoa Maurice Lucien Randriarison Jürgen May Jonas Schmidt-Chanasit Raphael Rakotozandrindrainy 《Emerging infectious diseases》2012,18(11):1780-1786
In October 2009, two–3 months after an outbreak of a febrile disease with joint pain on the eastern coast of Madagascar, we assessed serologic markers for chikungunya virus (CHIKV), dengue virus (DENV), and Rift Valley fever virus (RVFV) in 1,244 pregnant women at 6 locations. In 2 eastern coast towns, IgG seroprevalence against CHIKV was 45% and 23%; IgM seroprevalence was 28% and 5%. IgG seroprevalence against DENV was 17% and 11%. No anti-DENV IgM was detected. At 4 locations, 450–1,300 m high, IgG seroprevalence against CHIKV was 0%–3%, suggesting CHIKV had not spread to higher inland-altitudes. Four women had IgG against RVFV, probably antibodies from a 2008 epidemic. Most (78%) women from coastal locations with CHIKV-specific IgG reported joint pain and stiffness; 21% reported no symptoms. CHIKV infection was significantly associated with high bodyweight. The outbreak was an isolated CHIKV epidemic without relevant DENV co-transmission. 相似文献
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Norbert G. Schwarz Raphael Rakotozandrindrainy Jean N. Heriniaina Njary Randriamampionona Andreas Hahn Benedikt Hogan Hagen Frickmann Denise Dekker Sven Poppert Tsiriniaina Razafindrabe Jean P. Rakotondrainiarivelo Jürgen May Ralf M. Hagen 《Acta tropica》2014
Madagascar is an endemic area for schistosomiasis, but recent prevalence data are scarce. We investigated stool samples of 410 children aged 4–18 years from a combined primary and secondary school in a Madagascan highland village near Ambositra in order to assess the prevalence of Schistosoma mansoni using microscopy and real-time polymerase chain reaction (PCR). A high prevalence of S. mansoni of 77.1% was detected by PCR, while only 15.2% of microscopic examinations of sedimentation-enriched stools were positive. We estimated the sensitivity and specificity of stool sedimentation microscopy (19.7% and 98.8%) and of PCR (98.9% and 89.3%) using a Bayesian approach for two dependant tests in one population without a reference standard. Our Bayesian posterior estimate of the prevalence is 80.2%. Simple sedimentation technique misses about 4/5 of all PCR-confirmed infections and is insufficient to determine the prevalence of S. mansoni. A survey comparing PCR with a classical standard technique (KatoKatz) is desirable. 相似文献
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