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To compare 0.5% centbucridine and 2% lignocaine (with adrenaline) as local anesthetic agents for dental treatment procedures in 12 to 14 y old children. A split mouth, triple blind randomised controlled trial design was adopted for this study. Fifty six children between 12 to 14 y of age requiring bilateral administration of inferior alveolar nerve block (IANB) were recruited for this study. The mandibular quadrants were randomly allotted to the drug being administered. Standardised protocol for local anesthesia administration was used. The primary outcomes assessed were onset, duration and depth of anesthesia using the pre-validated Visual Analog scale and effect on perioperative pulse rate using a pulse oximeter. There was no significant difference between centbucridine and lignocaine with respect to their mean onset [(105.181 and 99.727 s respectively), (p = 0.647)], duration of action [(91.931 and 91.613 min respectively), (p = 0.931)] and depth of anesthesia at 10, 30 and 60 min. Centbucridine showed a statistically significant drop in the pulse rate at 10 (p < 0.001) and 30 min (p < 0.001). There was no significant difference between 0.5% centbucridine and 2% lignocaine with respect to onset, duration and depth of anesthesia. 相似文献
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Prapid Nair M Krishnan Nair Puthuveetil G Jayaprakash M Radhakrishna Pillai 《Pathology oncology research : POR》1999,5(2):95-103
The relationship between apoptosis, apoptosis regulatory proteins, cell proliferation and human papillomavirus infection during
various phases of tumor progression in the uterine cervix was studied. Apoptosis was defined by morphological criteria and
the TUNEL assay. Expression of p53, bcl-2, bax, cyclin D1, Ki 67 and E6 protein was evaluated by immunocytochemistry. Presence
of mutant p53 was detected using a mutant specific ELISA. Type of HPV infection was determined by PCR using type specific
primers. Apoptosis showed significant negative correlation with increasing histological abnormality (p=0.0005). Higher tumor
cell proliferation was associated with increasing histological abnormality (p=0.001 for Ki 67 and cyclin D1). There was significant
correlation between histological grade and immunoreactivity of p53 (p=0.0001 ) and bcl-2 (p=0.0002). However, mutant p53 was
expressed by only 12 of the 230 samples. Expression of bax and the bax/bcl-2 ratio showed an inverse correlation to histological
grade (p=0.0003 and 0.0001, respectively). There was also an inverse correlation between extent of apoptosis and immunoreactivity
of p53 (p=0.0001) and bcl-2 (p=0.0001). A significant positive correlation between expression of the bax protein and apoptosis
was evident (p=0.0001). HPV infection significantly correlated to the extent of histological abnormality (p=0.0001). High
risk HPV-E6 protein also showed this significant correlation (p=0.0002). There was an inverse correlation between apoptosis
and HPV infection (p=0.0002). High risk HPV infection was associated with decreased apoptosis and also increased human cell
proliferation. Lowest levels of bax/bcl-2 ratio was also associated with HPV 16 and 18 infection (p=0.0001). Modulation of
apoptosis and apoptotic regulatory proteins by high risk HPV infection may be an important factor in the development of cervical
cancer. 相似文献
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Talwar Ankoor A. Perry Nikhita J. McAuliffe Phoebe B. Desai Abhishek A. Thrippleton Sheri Broach Robyn B. Fischer John P. 《Hernia》2022,26(6):1635-1643
Hernia - Ventral hernia repair (VHR) can be augmented with biosynthetic poly-4-hydroxybutryate mesh (P4HB). Long-term outcomes, including quality of life outcomes, after VHR with P4HB mesh are not... 相似文献
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Terry Li Meghna Siddoji Jen Hoogenes Camilla Tajzler Nikhita Singhal Anil Kapoor 《Canadian Urological Association journal》2022,16(5):E240
IntroductionTuberous sclerosis complex (TSC) is a rare, multi-system, genetic disease. A significant cause of TSC-related morbidity is potential bleeding from renal angiomyolipoma (AML). To pre-emptively decrease AML bleeding, mTOR inhibitors can be used; however, thresholds for initiating and maintaining everolimus therapy remain uncertain. Recent literature suggests not triggering active treatment of AMLs based on size thresholds alone. We evaluated the appropriateness of initiating everolimus therapy in asymptomatic patients after considering AML size, rate of growth, and other factors.MethodsDiagnostic criteria developed by the 2012 International TSC Consensus Group and presence of AML were used as inclusion criteria. Medical and imaging reports of 11/20 TSC patients from a single center were reviewed.ResultsMean age was 40.55 (±16.27) and 11 patients were female. Eight asymptomatic patients at high risk for complications underwent everolimus therapy, of which seven (88%) demonstrated decreased AML size, but multiple side effects were reported. Four high-risk asymptomatic patients did not undergo therapy due to side effect concerns, while four low-risk asymptomatic patients had stable AMLs under active surveillance. Four patients had reduced AMLs through local therapy.ConclusionsEverolimus treatment was effective for managing AML size in most high-risk, asymptomatic patients with tolerable side effects. AML size can remain relatively stable for asymptomatic, low-risk patients despite not receiving intervention(s). Patients with TSC-related AML can be safely managed with mTOR inhibitors like everolimus with shared decision-making, including factors such as bleeding risk, AML growth rate, and number and absolute size of AMLs. 相似文献
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Concentrations of immune marker in newborn dried blood spots and early childhood development: Results from the Upstate KIDS Study 下载免费PDF全文
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Anita Wischmeijer Lut Van Laer Giada Tortora Nikhita Ajit Bolar Guy Van Camp Erik Fransen Nils Peeters Roberto di Bartolomeo Davide Pacini Gaetano Gargiulo Simone Turci Marco Bonvicini Elisabetta Mariucci Luigi Lovato Stefano Brusori Marco Ritelli Marina Colombi Livia Garavelli Marco Seri Bart L. Loeys 《American journal of medical genetics. Part A》2013,161(5):1028-1035
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