全文获取类型
收费全文 | 1924篇 |
免费 | 108篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 52篇 |
儿科学 | 125篇 |
妇产科学 | 39篇 |
基础医学 | 191篇 |
口腔科学 | 59篇 |
临床医学 | 150篇 |
内科学 | 485篇 |
皮肤病学 | 112篇 |
神经病学 | 115篇 |
特种医学 | 41篇 |
外科学 | 170篇 |
综合类 | 40篇 |
一般理论 | 2篇 |
预防医学 | 74篇 |
眼科学 | 126篇 |
药学 | 171篇 |
中国医学 | 7篇 |
肿瘤学 | 76篇 |
出版年
2023年 | 23篇 |
2022年 | 52篇 |
2021年 | 100篇 |
2020年 | 41篇 |
2019年 | 78篇 |
2018年 | 107篇 |
2017年 | 43篇 |
2016年 | 66篇 |
2015年 | 58篇 |
2014年 | 92篇 |
2013年 | 106篇 |
2012年 | 181篇 |
2011年 | 133篇 |
2010年 | 86篇 |
2009年 | 72篇 |
2008年 | 80篇 |
2007年 | 92篇 |
2006年 | 63篇 |
2005年 | 72篇 |
2004年 | 53篇 |
2003年 | 63篇 |
2002年 | 57篇 |
2001年 | 28篇 |
2000年 | 32篇 |
1999年 | 34篇 |
1998年 | 12篇 |
1997年 | 8篇 |
1996年 | 10篇 |
1995年 | 5篇 |
1994年 | 3篇 |
1993年 | 5篇 |
1992年 | 18篇 |
1991年 | 13篇 |
1990年 | 18篇 |
1989年 | 11篇 |
1988年 | 12篇 |
1987年 | 12篇 |
1986年 | 7篇 |
1985年 | 7篇 |
1984年 | 9篇 |
1983年 | 5篇 |
1981年 | 4篇 |
1980年 | 3篇 |
1979年 | 7篇 |
1976年 | 5篇 |
1975年 | 6篇 |
1974年 | 10篇 |
1973年 | 5篇 |
1971年 | 9篇 |
1967年 | 2篇 |
排序方式: 共有2035条查询结果,搜索用时 15 毫秒
1.
2.
3.
BackgroundExcessive consumption of ethanol is known to activate the mTORC1 pathway and to enhance the Collapsin Response Mediator Protein-2 (CRMP-2) levels in the limbic region of brain. The latter helps in forming microtubule assembly that is linked to drug taking or addiction-like behavior in rodents. Therefore, in this study, we investigated the effect of lacosamide, an antiepileptic drug and a known CRMP-2 inhibitor, which binds to CRMP-2 and inhibits the formation of microtubule assembly, on ethanol-induced conditioned place preference (CPP) in mice.MethodsThe behavior of mice following ethanol addiction and withdrawal was assessed by performing different behavioral paradigms. Mice underwent ethanol-induced CPP training with alternate dose of ethanol (2 g/kg, po) and saline (10 ml/kg, po). The effect of lacosamide on the expression of ethanol-induced CPP and on ethanol withdrawal associated anxiety and depression-like behavior was evaluated. The effect of drug on locomotor activity was also assessed and hippocampal CRMP-2 levels were measured.ResultsEthanol-induced CPP was associated with enhanced CRMP-2 levels in the hippocampus. Lacosamide significantly reduced the expression of ethanol-induced CPP and alleviated the levels of hippocampal CRMP-2 but aggravated withdrawal-associated anxiety and depression in mice.ConclusionThe present study demonstrated the beneficial effect of lacosamide in attenuation of expression of ethanol induced conditioned place preference via reduction of hippocampal CRMP-2 level. These findings suggest that lacosamide may be investigated further for ethanol addiction but not for managing withdrawal. 相似文献
4.
5.
6.
Piceatannol (3,4,3',5'-tetrahydroxy-trans-stilbene) (NSC 365798) has recently been isolated and was subsequently synthesized for NCI tumor panel testing as a new antileukemic natural product from the seeds of Euphorbia lagascae. During the synthesis, a bioactive reaction mixture of several partially O-methylated piceatannol analogues was obtained. This mixture has now been maximized and subjected to bioactivity-directed fractionation, using brine shrimp lethality, to yield 3,3',5'-tri-O-methylpiceatannol (NSC 381281); this new compound has improved stability and better bioactivity in several systems than piceatannol itself. To confirm the structure, 5 was synthesized from vanillin. In addition, the isovanillin analogue, 4,3',5'-tri-O-methylpiceatannol (NSC 381864), another new compound, was synthesized and found to be bioactive. 相似文献
7.
8.
Bioactive stilbenes of Scirpus maritimus 总被引:1,自引:0,他引:1
9.
In the present work we report our studies on IgG separated from the serum of lepromatous patients and non-lepromatous leprosy cases using Laser Raman Spectroscopy. Striking spectral changes in LL cases have been observed in the following special regions: (a) the amide I and III, (b) the S-S and C-S stretching (c) the skeletal bending and (d) skeletal stretching regions. These changes indicate a decrease in the amount of beta-structure and a transition towards alpha-helical conformation. 相似文献
10.
R. Srinivas Reddy S. Bajaj A. R. Tolat J. Compson 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2007,17(4):373-376
Neurofibromas in the hand are uncommon and constitute less than 5% of all hand tumours. Accurate diagnosis and appropriate management are important because malignant transformation has been reported, especially in Von Recklinghausen’s neurofibromatosis. We report a case of a large neurofibroma in the right hand of an 18-year-old girl of Afro-Caribbean origin. She was symptomatic with complaints of pain and weakness of grip. General examination revealed multiple café-au-lait spots on the trunk and one nodular swelling in the forearm. The swelling was excised through a palmar approach and histology proved it to be a neurofibroma. The case is being reported for its rarity and it emphasizes the importance of general examination. Histopathological examination is vital in excluding malignant transformation. 相似文献