全文获取类型
收费全文 | 600篇 |
免费 | 33篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 17篇 |
妇产科学 | 32篇 |
基础医学 | 65篇 |
口腔科学 | 16篇 |
临床医学 | 62篇 |
内科学 | 91篇 |
皮肤病学 | 20篇 |
神经病学 | 48篇 |
特种医学 | 7篇 |
外科学 | 92篇 |
综合类 | 8篇 |
预防医学 | 36篇 |
眼科学 | 57篇 |
药学 | 31篇 |
中国医学 | 1篇 |
肿瘤学 | 27篇 |
出版年
2024年 | 1篇 |
2023年 | 5篇 |
2022年 | 13篇 |
2021年 | 35篇 |
2020年 | 14篇 |
2019年 | 21篇 |
2018年 | 18篇 |
2017年 | 13篇 |
2016年 | 24篇 |
2015年 | 22篇 |
2014年 | 30篇 |
2013年 | 38篇 |
2012年 | 62篇 |
2011年 | 64篇 |
2010年 | 22篇 |
2009年 | 23篇 |
2008年 | 26篇 |
2007年 | 27篇 |
2006年 | 42篇 |
2005年 | 33篇 |
2004年 | 27篇 |
2003年 | 16篇 |
2002年 | 14篇 |
2001年 | 11篇 |
2000年 | 5篇 |
1999年 | 8篇 |
1998年 | 2篇 |
1995年 | 1篇 |
1992年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1986年 | 1篇 |
1982年 | 1篇 |
1976年 | 2篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
1957年 | 1篇 |
1956年 | 1篇 |
1954年 | 1篇 |
1947年 | 1篇 |
1927年 | 1篇 |
排序方式: 共有634条查询结果,搜索用时 31 毫秒
1.
2.
Sayime Aydin Bulent Ertugrul Berna Gultekin Guliz Uyar Erkin Kir 《BMC infectious diseases》2007,7(1):87
Background
Endophthalmitis is the inflammatory response to invasion of the eye with bacteria or fungi. The incidence of endophthalmitis after cataract surgery varies between 0.072–0.13 percent. Treatment of endophthalmitis with fungal etiology is difficult. 相似文献3.
4.
With regard to cadmium toxicity, Drosophila strains v;bw and Austin represent extremes in resistance and sensitivity, respectively. Both strains produced metallothionein (MT) in response to Cd ions in their diet. Austin produced more metallothionein than v;bw at Cd ion levels below 0.2 mM, when both strains were allowed lifetime development on Cd2+-containing media. When the rate of MT appearance was measured for 4 days in young adults the results showed no clear trend with time within a strain or between strains. The plot of LC50 vs. MT levels for identical developmental conditions revealed that for v;bw small increases in MT corresponded to large increases in resistance whereas for the sensitive Austin even large increases in MT had comparatively little effect on increasing LC50. Results given here suggest that differences in total MT content do not explain the genetically demonstrable difference in Cd2+-resistance between v;bw and Austin. However, since two MT genes are identified in Drosophila, differences in resistance could be reflective of greater relative amounts of one "more important" MT in the resistant fly. 相似文献
5.
M I Steele T L Kuhls K Nida C S Meka I M Halabi D A Mosier W Elliott D L Crawford R A Greenfield 《Infection and immunity》1995,63(10):3840-3845
6.
F. A. Uyar N. Ìmeryüz G. Saruhan-Direskeneli H. eken
.
zdog
an S S ahin N. Tzün 《International journal of immunogenetics》1998,25(4):293-296
Recently described distinct associations of HLA class II genes with ulcerative colitis (UC) suggest a genetic heterogeneity for disease susceptibility. In this study, HLA-DRB alleles of UC patients (n = 59) from Turkey were investigated and compared with healthy controls (n = 244). Using molecular genotyping by polymerase chain reaction (PCR) and sequence-specific oligonucleotide hybridization, we have shown a positive association of UC patients with the HLA-DRB1*1502 allele (10/59 vs. 16/244; P = 0.02; OR: 2.9) and a negative association with the DRB1*13 allele (7/59 vs. 64/244; P = 0.03; OR: 0.38) compared to controls. HLA-DRB1*0701 was significantly increased in perinuclear antineutrophil cytoplasmic antibody (pANCA)-positive UC patients compared to pANCA-negative patients (8/32 vs. 0/27; P = 0.005), whereas DRB1*1502 was observed more frequently in pANCA-negative patients (8/27 vs. 2/32; P = 0.03). These results extended the reported positive association of DRB1*1502 with UC to another population and supported the genetic susceptibility associated with HLA genes for disease development. 相似文献
7.
We report the evaluation of MHC class II polymorphism in the population of Turkey. HLA-DRB1, -DQA1 and -DQB1 have been investigated by polymerase chain reaction and sequence-specific oligonucleotide probe hybridisations (PCR/SSO) and sequence-specific priming (SSP) in 250 randomly selected healthy individuals. We also report the allelic distribution of these genes. The most frequent alleles detected were DRB1*1101 (0.104), *0301 (0.092), *0701 (0.090), DQA1*0501 (0.334), *0102 (0.164) and *03 (0.148) and DQB1*0301 (0.256), *02 (0.164), *0302 (0.128). The frequent 'putative' three-locus haplotypes carry the most frequent alleles at these loci. The most frequently detected class II "haplotypes" are DRB1*1101 DQA1*0501 DQB1*0301 (0.100), DRB1*0301 DQA1*0501 DQB1*02 (0.092) and DRB1*0701 DQA1*0201 DQB1*02 (0.072). The distribution of alleles and 'putative' haplotypes has shown common features with other Mediterranean populations. The results extend the HLA map to another Mediterranean country and provide a database for further HLA-disease association studies and transplantation applications. 相似文献
8.
Fatima Nida Massaad Elie Hadzipasic Muhamed Shankar Ganesh M. Shin John H. 《Neurosurgical review》2021,44(3):1357-1370
Neurosurgical Review - Treatment of osteoporosis with medications like teriparatide, a parathyroid hormone, is known to improve bone density and reduce the risk of osteoporotic vertebral fractures.... 相似文献
9.
A laryngocele is an air-filled dilation of the saccule of the larynx. An infected laryngocele is called a laryngopyocele. Our experience with a case of laryngopyocele with signs on computed tomography before and after antibiotic therapy is presented since laryngopyocele is more unusual. 相似文献
10.
İpek Ulu Yasemin Çekmez Şule Yıldırım Köpük Nida Özer Eser Evrim Yoğurtçuoğlu Pınar Anğın 《The journal of maternal-fetal & neonatal medicine》2019,32(15):2543-2546
Purpose: The aim of the study was to investigate whether maternal serum TSP-1 level was associated with PE.Materials and methods: In our case control study, 84 pregnant women in the third trimester were included. Forty-one of them were healthy and 43 of them were with the diagnosis of PE. The diagnosis was based on the definitions of the National High Blood Pressure Education Program working Group on High Blood Pressure in Pregnancy. Preeclamptic patients were divided into two subgroups as mild and severe. Blood pressure (BP) of pregnant women were obtained in left-side lying position using a mercury sphygmomanometer after at least 10 minutes of rest. Ten milliliters of venous blood was taken from every pregnant women and dispensed into lithium heparin and serum was obtained. Samples were stored at ?80?°C until analyzed. Serum TSP-1 level was measured using enzyme-linked immunosorbent assay (ELISA). All tests were two-tailed and p < .05 was considered to be statistically significant.Results: TSP-1 level was significantly lower in PE group than in controls (p?=?.003). Platelet counts were similar in two groups (p = .26). TSP-1 levels were significantly lower in severe PE than in mild PE cases. According to the subgroup analysis, TSP-1 level was found significantly lower in severe preeclampsia group compared to control group (p = .015).Conclusions: In light of the association between endothelial dysfunction and preeclampsia, we claim that lower levels of TSP-1 which is released mostly from endothelial cells seem to reflect disease severity in PE. Our study reveals that maternal serum TSP-1 levels decrease in pregnant women presenting with PE and TSP-1 may be a new biomarker for the detection of PE and even severity of it. Further studies especially prospective ones with greater numbers of cases are needed. 相似文献