全文获取类型
收费全文 | 184篇 |
免费 | 12篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 6篇 |
妇产科学 | 1篇 |
基础医学 | 11篇 |
口腔科学 | 14篇 |
临床医学 | 10篇 |
内科学 | 96篇 |
皮肤病学 | 4篇 |
神经病学 | 2篇 |
特种医学 | 2篇 |
外科学 | 27篇 |
综合类 | 2篇 |
预防医学 | 6篇 |
眼科学 | 1篇 |
药学 | 4篇 |
中国医学 | 4篇 |
肿瘤学 | 7篇 |
出版年
2023年 | 4篇 |
2022年 | 3篇 |
2021年 | 6篇 |
2020年 | 5篇 |
2019年 | 9篇 |
2018年 | 8篇 |
2017年 | 3篇 |
2016年 | 9篇 |
2015年 | 3篇 |
2014年 | 11篇 |
2013年 | 11篇 |
2012年 | 11篇 |
2011年 | 9篇 |
2010年 | 6篇 |
2009年 | 7篇 |
2008年 | 17篇 |
2007年 | 10篇 |
2006年 | 9篇 |
2005年 | 10篇 |
2004年 | 9篇 |
2003年 | 6篇 |
2002年 | 5篇 |
2001年 | 1篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 1篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1978年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有197条查询结果,搜索用时 46 毫秒
1.
2.
Sonita Afschar Janne M. Toivonen Julia Marianne Hoffmann Luke Stephen Tain Daniela Wieser Andrew John Finlayson Yasmine Driege Nazif Alic Sahar Emran Julia Stinn Jenny Froehlich Matthew D. Piper Linda Partridge 《Proceedings of the National Academy of Sciences of the United States of America》2016,113(5):1321-1326
3.
Global analysis of proteasomal substrate specificity using positional-scanning libraries of covalent inhibitors 下载免费PDF全文
Nazif T Bogyo M 《Proceedings of the National Academy of Sciences of the United States of America》2001,98(6):2967-2972
The proteasome is a large protease complex consisting of multiple catalytic subunits that function simultaneously to digest protein substrates. This complexity has made deciphering the role each subunit plays in the generation of specific protein fragments difficult. Positional scanning libraries of peptide vinyl sulfones were generated in which the amino acid located directly at the site of hydrolysis (P1 residue) was held constant and sequences distal to that residue (P2, P3, and P4 positions) were varied across all natural amino acids (except cysteine and methionine). Binding information for each of the individual catalytic subunits was obtained for each library under a variety of different conditions. The resulting specificity profiles indicated that substrate positions distal to P1 are critical for directing substrates to active subunits in the complex. Furthermore, specificity profiles of IFN-gamma-regulated subunits closely matched those of their noninducible counterparts, suggesting that subunit swapping may modulate substrate processing by a mechanism that does require a change in the primary sequence specificity of individual catalytic subunits in the complex. Finally, specificity profiles were used to design specific inhibitors of a single active site in the complex. These reagents can be used to further establish the role of each subunit in substrate processing by the proteasome. 相似文献
4.
Bahira Shahim S. Chris Malaisrie Isaac George Vinod H. Thourani Angelo B. Biviano Mark Russo David L. Brown Vasilis Babaliaros Robert A. Guyton Susheel K. Kodali Tamim M. Nazif Samir Kapadia Philippe Pibarot James M. McCabe Mathew Williams Philippe Genereux Michael Lu Xiao Yu Ioanna Kosmidou 《JACC: Cardiovascular Interventions》2021,14(14):1565-1574
ObjectivesThe aim of this study was to assess the incidence and prognostic impact of early and late postoperative atrial fibrillation or flutter (POAF) in patients with severe aortic stenosis (AS) treated with transcatheter aortic valve replacement (TAVR) or surgical aortic valve replacement (SAVR).BackgroundThere is an ongoing controversy regarding the incidence, recurrence rate, and prognostic impact of early (in-hospital) POAF and late (postdischarge) POAF in patients with AS undergoing TAVR or SAVR.MethodsIn the PARTNER (Placement of Aortic Transcatheter Valve) 3 trial, patients with severe AS at low surgical risk were randomized to TAVR or SAVR. Analyses were performed in the as-treated population excluding patients with preexistent atrial fibrillation or flutter.ResultsAmong 781 patients included in the analysis, early POAF occurred in 152 (19.5%) (18 of 415 [4.3%] and 134 of 366 [36.6%] following TAVR and SAVR, respectively). Following discharge, 58 new or recurrent late POAF events occurred within 1 year following the index procedure in 55 of 781 patients (7.0%). Early POAF was not an independent predictor of late POAF following discharge (odds ratio: 1.04; 95% CI: 0.52-2.08; P = 0.90). Following adjustment, early POAF was not an independent predictor of the composite outcome of death, stroke, or rehospitalization (hazard ratio: 1.10; 95% CI: 0.64-1.92; P = 0.72), whereas late POAF was associated with an increased adjusted risk for the composite outcome (hazard ratio: 8.90; 95% CI: 5.02-15.74; P < 0.0001), irrespective of treatment modality.ConclusionsIn the PARTNER 3 trial, early POAF was more frequent following SAVR compared with TAVR. Late POAF, but not early POAF, was significantly associated with worse outcomes at 2 years, irrespective of treatment modality. 相似文献
5.
Philippe Généreux Nicolo Piazza Maria C. Alu Tamim Nazif Rebecca T. Hahn Philippe Pibarot Jeroen J. Bax Jonathon A. Leipsic Philipp Blanke Eugene H. Blackstone Matthew T. Finn Samir Kapadia Axel Linke Michael J. Mack Raj Makkar Roxana Mehran Jeffrey J. Popma Martin B. Leon 《Journal of the American College of Cardiology》2021,77(21):2717-2746
6.
7.
8.
Kamia Thakur MD Tamim M. Nazif MD Omar K. Khalique MD FACC FASE FSCCT Jean‐Michel Paradis MD Kishore J. Harjai MD 《Journal of interventional cardiology》2018,31(5):543-552
9.
10.