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排序方式: 共有100条查询结果,搜索用时 702 毫秒
1.
TNFα and IL‐17A are differentially expressed in psoriasis‐like vs eczema‐like drug reactions to TNFα antagonists
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2.
A.E. Arafa F. Anzengruber A.M. Mostafa A.A. Navarini 《Journal of the European Academy of Dermatology and Venereology》2019,33(3):511-520
The striking rise in the Internet utilization worldwide has led to major changes in the methods of data collection and processing. Online surveying has been used to assess different health services, explore patients’ perceptions and measure interventions. The discipline of dermatology is one of the fields that gained benefits from surveying patients and dermatologists online; however, some disadvantages such as the low response rate and participation bias were suggested. This review summarizes the applications of online surveying in dermatology and discusses the methods of enhancing response to online surveys. It also offers a guide for dermatologists to formulate their online surveys and avoid the possibility of bias. The role of social network in data collection and the concerns about anonymity and data security have been discussed. 相似文献
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Navarini Luca Costa Luisa Tasso Marco Chimenti Maria Sole Currado Damiano Fonti Giulia Lavinia Ciccozzi Massimo Margiotta Domenico Paolo Emanuele Benigno Carolina De Martino Erica Perricone Roberto Afeltra Antonella Scarpa Raffaele Caso Francesco 《Clinical rheumatology》2020,39(9):2663-2670
Clinical Rheumatology - Biologic disease-modifying antirheumatic drugs (bDMARDs) play a pivotal role in the treatment of psoriatic arthritis (PsA). Despite this, their discontinuation due to... 相似文献
6.
Jushya Bhatia Ankur Sarin Uwe Wollina Torello Lotti Alexander A. Navarini Simon M. Mueller Stephan Grabbe Joachim Saloga Ghasem R. Rokni Mohamad Goldust 《Contact dermatitis》2020,83(3):179-181
The resistant and recalcitrant nature of severe allergic contact dermatitis (ACD) makes its management challenging. With advances in the understanding of the cellular and molecular pathogenesis of ACD, newer therapeutic targets are becoming apparent. In particular, the use of biologics has gained momentum, given the specificity of their action. This article aims to review the presently available data on the use of biologics in ACD. English-language–based literature available on the use of biological therapy was thoroughly probed in the following databases as on October 14, 2019: PubMed, Google Scholar, The Cochrane library, Embase, Scopus, and EBSCO. The following keywords were used: “contact dermatitis”, “allergens”, “delayed-type hypersensitivity reaction”, “biologics”, “biological therapy”, “monoclonal antibodies”, “patch testing”, “TNF-α inhibitors”, “infliximab”, “adalimumab”, “etanercept”, “dupilumab”, “omalizumab”, “secukinumab”, “ustekinumab”, “rituximab”. 相似文献
7.
Valentina N. S. Hongler Alexander Navarini Oliver Brandt Mohamad Goldust Simon M. Mueller 《Dermatologic therapy》2020,33(4)
To date, the geographical distribution and global trends of search activities on psoriasis and atopic eczema on Google and YouTube are widely unknown. The aim of this study was to identify geographic and temporal trends in YouTube and Google search activities for psoriasis and atopic eczema. We used specific filter settings on Google Trends to indicate the global search activity for (“Psoriasis”) and (“Atopic Eczema”) on Google and YouTube between January 1st, 2008 and August 7th, 2019. The four resulting data sets were analyzed and compared with respect to geographic distribution and temporal trends. Apart from a few “blind spots” (eg, Chad, Uzbekistan) the term “Psoriasis” was queried geographically fairly evenly distributed. The opposite was true for “Atopic Eczema”, which was predominantly queried from a few “hot spots” (eg, United States, Commonwealth of Nations and Sweden). Since 2008, the search activity on YouTube for “Psoriasis” has tripled, while that for “Atopic Eczema” has decreased. On Google, by contrast, search activity has risen for both “Psoriasis” and “Atopic Eczema.” Google Trends can be a useful tool to track people's/patients' interests and search search behavior over time, enabling, for instance, regionally tailored information and prevention campaigns. 相似文献
8.
R. Lichtenberger M.A. Simpson C. Smith A.A. Navarini 《Journal of the European Academy of Dermatology and Venereology》2017,31(12):1978-1990
Acne vulgaris is a ubiquitary skin disease characterized by chronic inflammation of the pilosebaceous unit resulting from bacterial colonization of hair follicles by Propionibacterium acnes, androgen‐induced increased sebum production, altered keratinization and inflammation. Here, we review our current understanding of the genetic architecture of this intriguing disease. We analysed genomewide association studies (GWAS) and candidate genes studies for acne vulgaris. Moreover, we included GWAS studies for the associated disease polycystic ovary syndrome (PCOS). Overall, the available data revealed sixteen genetic loci flagged by single nucleotide polymorphisms (SNPs), none of which has been confirmed yet by independent studies. Moreover, a GWAS for PCOS identified 21 susceptible loci. The genetic architecture is complex which has been revealed by GWAS. Further and larger studies in different populations are required to confirm or disprove results from candidate gene studies as well to identify signals that may overlap between different populations. Finally, studies on rare genetic variants in acne and associated diseases like PCOS may deepen our understanding of its pathogenesis. 相似文献
9.
Antonietta Gigante Domenico Margiotta Luca Navarini Biagio Barbano Maria L. Gasperini Claudia D'Agostino Antonio Amoroso Antonella Afeltra Edoardo Rosato 《International wound journal》2018,15(3):424-428
Patients with systemic sclerosis (SSc) are at a high risk of the development of ischaemic digital ulcers (DUs) that can be complicated with infections, gangrene, and osteomyelitis. The aim of this study is to evaluate the role of endostatin in scleroderma DUs.In total, 90 SSc patients were enrolled in this study. Serum endostatin levels and DU assessment were determined in all SSc patients. The serum levels of endostatin significantly increased with progression of capillaroscopic damage (P < .01). The serum levels of endostatin are significantly (P < .05) higher in SSc patients with new DUs than in SSc patients without new DUs (127 ± 31.1 ng/mL vs 116.3 ± 39.7 ng/mL). The Receiver Operating Characteristic (ROC) curves demonstrated good accuracy of new DU prediction for the serum level of endostatin (0.70, P < .01 [95% confidence interval (CI) 0.59‐0.81]). Using a cut‐off value of 116 ng/mL, the odds ratio was 2.609 (CI 1.075‐6.330, P < .05). The serum levels of endostatin are significantly (P < .01) higher in SSc patients with infected DUs than in SSc patients without infected DUs (139.2 [114.6‐340.91] ng/mL vs 117.5 [64.3‐163.9] ng/mL). Serum levels of endostatin are higher in patients with DUs, especially in those with infected DUs. 相似文献
10.
Anajara Gazzalle Débora Braun Leandro Totti Cavazzola Luiz Roberto Wendt Daniel Navarini Marcelo de Azevedo Fauri Santo Pascual Vitola 《Obesity surgery》2010,20(12):1740-1742
This is a case of a 33 weeks pregnant woman, presented 2 years after laparoscopic Roux-en-Y gastric bypass, with abdominal
pain for 2 days. A laparoscopic cholecystectomy was performed 1 day earlier in another hospital, without improving the pain.
She presented at our hospital with acute abdominal pain and clinical signs of intestinal obstruction, undergoing an exploratory
laparotomy that revealed a volvulus and necrosis of the jejunum from the gastroenteroanastomosis through the lateral enteroenterostomy,
which was resected with the reconstruction of the Roux-en-Y limb performed at the same operation. Patient and neonate presented
with improvement after surgery and the patient was discharged on postoperative day 15. Internal hernias after bariatric surgery
have been reported as the cause of acute abdomen problems during pregnancy, which may progress to necrosis and perforation.
The delay of surgical intervention could have brought a tragic outcome for mother and neonate. 相似文献