排序方式: 共有18条查询结果,搜索用时 15 毫秒
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Axelrod Lindsay Axelrod Steve Navalgund Anand Triadafilopoulos George 《Digestive diseases and sciences》2021,66(10):3505-3515
Digestive Diseases and Sciences - Limited means exist to assess gastrointestinal activity in a noninvasive, objective way that is highly predictive of underlying motility disorders. The aim of this... 相似文献
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Joseph W. Pittman Anand Navalgund Steve H. Byun Hechang Huang Albert H. Kim Do-Gyoon Kim 《Clinical oral investigations》2014,18(3):721-728
Objectives
The objective of this study was to examine whether cortical bone thickness and bone mineral density (BMD) can explain the primary migration of a mini-implant under a functional orthodontic tangential loading at the early stage following implantation.Materials and methods
Mini-implants were installed in human mandibular sections. A constant tangential load (2 N) was applied to the mini-implant under hydration. Creep, which is a time-dependent viscoelastic displacement in the bone surrounding the mini-implant, was assessed as the change in displacement during 2 h of loading. The total migration was measured as a maximum displacement that combined an initial elastic displacement and creep. After removal of the mini-implant, all specimens were scanned together by cone beam computed tomography. Cortical bone thickness and BMD were measured for the bone voxels surrounding the implant site.Results
BMD had significant correlations with the displacement parameters (p?<?0.019), but the cortical bone thickness did not (p?>?0.272). Permanent bone deformation adjacent to the implant was observed to be resulting from substantial creep development under the orthodontic functional loading level.Conclusions
BMD controls the primary migration of the mini-implant system in mandibular bone. Viscoelastic creep can develop at a small constant functional loading level, leading to migration of the mini-implant.Clinical relevance
The current results indicated that mini-implant migration can develop under the small level of functional orthodontic load used in clinic. If the active bone remodeling around the mini-implant accelerates the migration, the risk of causing damage in vital organs next to the mini-implant increases. 相似文献4.
Massive pulmonary thromboembolism during liver transplantation 总被引:3,自引:0,他引:3
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Louis J. Raso MD Timothy R. Deer MD Sandford M. Schocket MD Jack A. Chapman MD Luis E. Duarte MD Rafael Justiz MD Kasra Amirdelfan MD Richard M. Paicius MD Yeshvant A. Navalgund MD George E. Girardi MD Neal E. Coleman MD Michael Verdolin MD Nameer Haider MD Steven Rosen MD Mark D. Netherton MD Michael Chad Owens DO Matthew T. Bennett MD Jason Rosenberg MD Shaun Jackson MD Christopher L. Nelson MD Timothy T. Davis MD 《Neuromodulation》2014,17(5):465-471
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Progressive vertebral deformation increases the fracture risk of a vertebral body in the postmenopausal patient. Many studies have observed that bone can demonstrate creep behavior, defined as continued time-dependent deformation even when mechanical loading is held constant. Creep is a characteristic of viscoelastic behavior, which is common in biological materials. We hypothesized that estrogen deficiency-dependent alteration of the mineral distribution of bone at the tissue level could influence the progressive postmenopausal vertebral deformity that is observed as the creep response at the organ level. The objective of this study was thus to examine whether the creep behavior of vertebral bone is changed by estrogen deficiency, and to determine which bone property parameters are responsible for the creep response of vertebral bone at physiological loading levels using an ovariectomized (OVX) rat model. Correlations of creep parameters with bone mineral density (BMD), tissue mineral density (TMD) and architectural parameters of both OVX and sham surgery vertebral bone were tested. As the vertebral creep was not fully recovered during the post-creep unloading period, there was substantial residual displacement for both the sham and OVX groups. A strong positive correlation between loading creep and residual displacement was found (r=0.868, p<0.001). Of the various parameters studied, TMD variability was the parameter that best predicted the creep behavior of the OVX group (p<0.038). The current results indicated that creep caused progressive, permanent reduction in vertebral height for both the sham and OVX groups. In addition, estrogen deficiency-induced active bone remodeling increased variability of trabecular TMD in the OVX group. Taken together, these results suggest that increased variability of trabecular TMD resulting from high bone turnover influences creep behavior of the OVX vertebrae. 相似文献
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Kimberly Szucs Anand Navalgund John D. Borstad 《Medical & biological engineering & computing》2009,47(5):487-495
Scapular muscles precisely move the scapulothoracic articulation and if fatigued may contribute to pathology. Fatigue of serratus
anterior may be a mechanism for shoulder pathology by altering scapula motions and requiring compensation by other shoulder
muscles. A total of 28 asymptomatic subjects performed a task to fatigue the serratus anterior, while muscle activity was
recorded from three muscles. Mean normalized activation levels and activation ratios were examined before and after the fatigue
task during arm elevation and lowering. All muscles demonstrated meaningful declines in the median frequency of the electromyographic
signal during the task. Following the task, only the upper trapezius had higher mean activation levels (mean difference 10.79%
MVIC), while the serratus anterior/lower trapezius activation ratio was altered (mean difference −0.3). Higher mean upper
trapezius activation may be compensatory for fatigue of other shoulder muscles and may reflect fiber type or central control
mechanisms. Serratus anterior eccentric endurance training may be beneficial for the prevention of shoulder pathology. 相似文献
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Epsilon-aminocaproic acid for treatment of fibrinolysis during liver transplantation 总被引:6,自引:0,他引:6
Y Kang J H Lewis A Navalgund M W Russell F A Bontempo L S Niren T E Starzl 《Anesthesiology》1987,66(6):766-773
In 97 adult patients receiving liver transplants, the coagulation system was monitored by thrombelastography and by coagulation profile including PT; aPTT; platelet count; level of factors I, II, V, VII, VIII, IX, X, XI, and XII; fibrin degradation products; ethanol gel test; protamine gel test; and euglobulin lysis time. Preoperatively, fibrinolysis defined as a whole blood clot lysis index of less than 80% was present in 29 patients (29.9%), and a euglobulin lysis time of less than 1 h was present in 13 patients. Fibrinolysis increased progressively during surgery in 80 patients (82.5%) and was most severe on reperfusion of the graft liver in 33 patients (34%). When whole blood clot lysis (F less than 180 min) was observed during reperfusion of the graft liver, blood coagulability was tested by thrombelastography using both a blood sample treated in vitro with epsilon-aminocaproic acid (0.09%) and an untreated sample. Blood treated with epsilon-aminocaproic acid showed improved coagulation without fibrinolytic activity in all 74 tests. When whole blood clot lysis time was less than 120 min, generalized oozing occurred, and the effectiveness of epsilon-aminocaproic acid was demonstrated in vitro during the pre-anhepatic and post-anhepatic stages, epsilon-aminocaproic acid (1 g, single intravenous dose) was administered. In all 20 patients treated with epsilon-aminocaproic acid, fibrinolytic activity disappeared; whole blood clot lysis was not seen on thrombelastography during a 5-h observation period, and whole blood clot lysis index improved from 28.5 +/- 29.5% to 94.8 +/- 7.4% (mean +/- SD, P less than 0.001). None of the treated patients had hemorrhagic or thrombotic complications.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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