全文获取类型
收费全文 | 3761篇 |
免费 | 208篇 |
国内免费 | 38篇 |
专业分类
耳鼻咽喉 | 87篇 |
儿科学 | 83篇 |
妇产科学 | 45篇 |
基础医学 | 646篇 |
口腔科学 | 104篇 |
临床医学 | 296篇 |
内科学 | 935篇 |
皮肤病学 | 61篇 |
神经病学 | 265篇 |
特种医学 | 85篇 |
外科学 | 574篇 |
综合类 | 10篇 |
一般理论 | 2篇 |
预防医学 | 96篇 |
眼科学 | 58篇 |
药学 | 262篇 |
中国医学 | 13篇 |
肿瘤学 | 385篇 |
出版年
2023年 | 34篇 |
2022年 | 44篇 |
2021年 | 78篇 |
2020年 | 46篇 |
2019年 | 74篇 |
2018年 | 72篇 |
2017年 | 87篇 |
2016年 | 78篇 |
2015年 | 77篇 |
2014年 | 104篇 |
2013年 | 134篇 |
2012年 | 218篇 |
2011年 | 235篇 |
2010年 | 117篇 |
2009年 | 104篇 |
2008年 | 160篇 |
2007年 | 190篇 |
2006年 | 187篇 |
2005年 | 224篇 |
2004年 | 179篇 |
2003年 | 191篇 |
2002年 | 182篇 |
2001年 | 145篇 |
2000年 | 88篇 |
1999年 | 102篇 |
1998年 | 34篇 |
1997年 | 24篇 |
1996年 | 38篇 |
1995年 | 24篇 |
1994年 | 30篇 |
1993年 | 32篇 |
1992年 | 86篇 |
1991年 | 55篇 |
1990年 | 53篇 |
1989年 | 58篇 |
1988年 | 50篇 |
1987年 | 40篇 |
1986年 | 44篇 |
1985年 | 30篇 |
1984年 | 28篇 |
1983年 | 26篇 |
1982年 | 13篇 |
1981年 | 14篇 |
1979年 | 16篇 |
1978年 | 16篇 |
1977年 | 19篇 |
1970年 | 11篇 |
1969年 | 16篇 |
1967年 | 14篇 |
1966年 | 14篇 |
排序方式: 共有4007条查询结果,搜索用时 15 毫秒
1.
2.
Yosuke Homma Takashi Shiga Hiraku Funakoshi Dai Miyazaki Atsushi Sakurai Yoshio Tahara Ken Nagao Naohiro Yonemoto Arino Yaguchi Naoto Morimura 《The American journal of emergency medicine》2019,37(2):241-248
Objective
This study assessed the association between the timing of first epinephrine administration (EA) and the neurological outcomes following out-of-hospital cardiac arrests (OHCAs) with both initial shockable and non-shockable rhythms.Methods
This was a post-hoc analysis of a multicenter prospective cohort study (SOS-KANTO 2012), which registered OHCA patients in the Kanto region of Japan from January 2012 to March 2013. We included consecutive adult OHCA patients who received epinephrine. The primary result included 1-month favorable neurological outcomes defined as cerebral performance category (CPC) 1 or 2. Secondary results included 1-month survival and return of spontaneous circulation (ROSC) after arrival at the hospital. Multivariable logistic regression analysis determined the association between delay per minute of the time from call to first EA in both pre- or in-hospital settings and outcomes.Results
Of the 16,452 patients, 9344 were eligible for our analyses. In univariable analysis, the delay in EA was associated with decreased favorable neurological outcomes only when the initial rhythm was a non-shockable rhythm. In multivariable analyses, delay in EA was associated with decreased ROSC (adjusted odds ratio [OR] for one minute delay, 0.97; 95% confidence interval [CI], 0.96–0.98) and 1-month survival (adjusted OR, 0.95; 95% CI, 0.92–0.97) when the initial rhythm was a non-shockable rhythm, whereas during a shockable rhythm, delay in EA was not associated with decreased ROSC and 1-month survival.Conclusions
While assessing the effectiveness of epinephrine for OHCA, we should consider the time-limited effects of epinephrine. Additionally, consideration of early EA based on the pathophysiology is needed. 相似文献3.
4.
Met-RANTES ameliorates fibrous airway obliteration and decreases ERK expression in a murine model of bronchiolitis obliterans. 总被引:1,自引:0,他引:1
Osamu Uchida Naohiro Kajiwara Aeru Hayashi Kuniharu Miyajima Takayoshi Nagatsuka Hiroki Hayashi Masahiro Taira Masakazu Kimura Masahiro Tsuboi Harubumi Kato 《Annals of thoracic and cardiovascular surgery》2007,13(2):82-86
OBJECTIVES: Bronchiolitis obliterans (BO) is the main cause of late mortality among long-term survivors of lung transplantation. Chemokine-chemokine receptor (CCR) interaction and subsequent recruitment of infiltrating cells to the graft are early events in the development of chronic rejection of transplanted lungs. The present study investigated whether blockade of chemokine receptors CCR1 and CCR5 with Met-regulated-on-activation, normal T cells expressed and secreted (RANTES), an amino-terminal modified derivative of RANTES/CCL5, affects the development of BO in murine model and we sought to determine the expression of RANTES/CCL5 and their relationship with extracellular signal-regulated kinase (ERK). Materials and Methods: BALB/c mouse tracheas were heterotopically transplanted into C57Black6 recipients and treated for 21 days with either Met-RANTES at 20 microg/day or vehicle. Animals were killed at 21 days after transplantation for histologic examination of ERK expression. RESULTS: RANTES/CCL5 was highly expressed in allografts compare to isografts. Met-RANTES treatment ameliorated fibrous airway obliteration in a mouse model of BO and decreased ERK expression. CONCLUSION: Blockade of chemokine receptors by Met-RANTES ameliorated airway obliteration and decreased ERK expression. These findings suggest that chemokine receptors CCR1 and CCR5 play significant roles in the development of chronic rejection and ERK may be a new molecular target for chronic rejection. 相似文献
5.
Yoshinori Igarashi Naoki Okano Ken Ito Takahiko Mimura Kazumasa Miki 《Digestive endoscopy》2007,19(Z1):S109-S114
A 69‐year‐old man was admitted to Toho University Omori Medical Center complaining of icterus. Abdominal computed tomography, magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography were suspicious of cholangioma of inferior bile duct. Peroral cholangioscopy using narrow band imaging (NBI) was performed and it was possible to diagnose the mucosal spread lesions of cholangioma. Histological findings reflected the endoscopic findings. Mucosal spread lesions of cholangiocarcinoma were successfully diagnosed using the CHF‐B260 for NBI. 相似文献
6.
Takahisa Okano Matthew D. Horton Gary G. Fermanis David A. Horton 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2005,53(8):437-439
We report a re-do case of severe aortic valve stenosis due to pannus formation 29 years after an aortic Starr-Edwards caged-ball
valve implantation. A huge shelf of calcified and thick pannus tissue below the valve had reduced the already small orifice
by at least a third in surface area. The explanted Starr-Edwards valve revealed no mechanical or structural failure. Early
detection and treatment of pannus outgrowth is essential in order to prevent life-threatening prosthetic valve malfunctions. 相似文献
7.
Phase I study of E1040, a new parenteral cephem antibiotic 总被引:1,自引:0,他引:1
M Nakashima T Uematsu M Kanamara K Ueno T Setoyama Y Tomono T Ohno K Okano N Morishita 《Journal of clinical pharmacology》1989,29(2):144-150
The safety and pharmacokinetics of E1040, a new injectable cephem antibiotic, were evaluated in healthy volunteers. In single-dose studies, 125, 250, 500, 1000 and 2000 mg of E1040 were administered by I.V. infusion over 1 hour. Results of 5 minutes I.V. infusions of 500, 1000 and 2000 mg of the drug were also studied. Plasma concentration-time profiles were well suited to a two-compartment open model. The half-life of elimination from plasma was 1.85 +/- 0.16 hours, and the Cmax and AUC paralleled the doses given. The mean urinary recovery within the first 24 hours was 85.7 +/- 6.43% of the dose. In a multiple-dose study, 2000 mg of E1040 (I.V. over 1 hour) was administered every 12 hours (total 9 times) and no abnormal accumulation of the drug in plasma was observed. There were no significant differences in plasma levels or in urinary recoveries between single- and multiple-dose regimens. There were no subjective or objective abnormal findings definitely attributable to the drug except that one subject given 250 mg over 1 hour reported diarrhea, and another complained of nausea during the infusion of 2000 mg over 5 minutes. From these results E1040 was concluded to be safe and well tolerated. 相似文献
8.
S Isaka T Okano J Shimazaki S Murakami T Hara S Kataumi T Yoshida T Nagayama T Wada Y Kitamura 《Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology》1992,83(10):1662-1667
Many reports about the increase of renal cell carcinoma patients have been published in Japan recently, however, the real fluctuations in the total number of patients in relation to the change of population have not been reported yet. Most of the patients with renal cell carcinoma in the last 10 years were examined in Chiba prefecture, which has a population of about five million and 25 active urological offices. Histologically confirmed cases were investigated by sending questionnaire letters. The items were as follows; sex, age, address, occupation, family history, past history, symptoms, examination methods that first detected the tumor, operation date, tumor diameter and clinical stage. Twenty two offices returned answers and 560 cases who lived in Chiba were found to have renal cell carcinoma from 1980 to 1989. Yearly incidence rates per 100,000 persons demonstrated a significant increase from 0.32 to 2.07. Small, asymptomatic and low stage cancers have been increasing rapidly, however, the rate of metastatic disease has not shown any decrease. The main cause of rapid increase seems to be attributed to progress in diagnostic methods and increase of early detection, but the possibility of an increase in some carcinogenic factors can not be ruled out. 相似文献
9.
The effects of platelet-derived growth factor (PDGF) on phospholipase D (PLD) activity and deoxyribonucleic acid (DNA) synthesis in rat C6 glioma cells have been investigated. Pretreatment of serum-starved C6 cells with PDGF results in enhanced choline production and the phosphatidylethanol (PEt) formation in the presence of ethanol, indicating the activation of PLD acting on phosphatidylcholine (PC). The dose-response curve for choline generation and DNA synthesis were comparable. In addition, the effects of PDGF on both PEt formation and [3H]thymidine incorporation into acid-precipitable material was blocked by the potent protein kinase C (PKC) inhibitor 1-(5-isoquinolinesulphonyl)-2-methylpiperazine (H-7) but not by N-(2-guanidinoethyl)-5-isoquinolinesulphonamide (HA1004), a relatively weak inhibitor of PKC, suggesting that PDGF plays an important role as a positive regulator of glioma cell growth via a PLD-mediated mitogenic signal transduction cascades, which depends largely on the activation of PKC. 相似文献
10.