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Vladimir Lj Lazarevic Myriam Labopin Wu Depei Ibrahim Yakoub‐Agha Anne Huynh Per Ljungman Nicolaas Schaap Jan J. Cornelissen Natacha Maillard Pietro Pioltelli Tobias Gedde‐Dahl Stig Lenhoff Mohamed Houhou Jordi Esteve Mohamad Mohty Arnon Nagler 《American journal of hematology》2018,93(1):31-39
The aim of the study was to assess the role of allogeneic stem cell transplantation (SCT) in patients diagnosed with BCR‐ABL1‐positive acute myeloid leukemia (AML). Fifty‐seven patients (median age, 48 years, range: 19‐67) with BCR‐ABL1 positive AML undergoing SCT were identified. The majority of the patients (70%) received a TKI before the transplant. At SCT 48 patients were in CR (45 in CR1), while 9 patients were transplanted in a more advanced stage of the disease. MRD was negative (BCR‐ABL1/ABL < 104) at time of SCT in 36.1% (14/40). After SCT, 16 (61.5%) out of 26 patients with MRD positive at transplantation reached MRD negativity. After a median follow‐up of 6.3 years (0.7–14.2), NRM, RI, LFS, OS, and GRFS at 5 years were 18.1%, 37%, 44.2%, 53.8%, and 32.1%, respectively. The cumulative incidence of acute GvHD grade II‐IV was 16.4%, incidence of chronic GvHD 24.9%, and of extensive cGvHD 21.4%, respectively. In patients who received SCT in CR1, 5‐yr NRM, RI, LFS, OS, and GRFS were 15.9%, 36.4%, 46.5%, 59.4%, and 34.9%, respectively. Univariate analysis showed that age (<50 vs. ≥50 years) was associated with RI (5‐yr: 22.7 vs. 50%), LFS (5‐yr: 61.9 vs. 31.8%), and GRFS (5‐yr: 52.4 vs. 18.2%), whereas MRD‐negative status before SCT was associated with an improved GRFS (38.9 vs. 16.7%). We conclude that the outcome of patients <50 years of age with BCR‐ABL1‐positive AML receiving allogeneic SCT in CR is relatively favorable, possibly reflecting the beneficial effect of the use of TKI. 相似文献
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Natural polymorphism of cytomegalovirus DNA polymerase lies in two nonconserved regions located between domains delta-C and II and between domains III and I 下载免费PDF全文
Fillet AM Auray L Alain S Gourlain K Imbert BM Najioullah F Champier G Gouarin S Carquin J Houhou N Garrigue I Ducancelle A Thouvenot D Mazeron MC 《Antimicrobial agents and chemotherapy》2004,48(5):1865-1868
We described the natural polymorphism of cytomegalovirus DNA polymerase in 42 unrelated isolates susceptible to ganciclovir, foscarnet, and cidofovir. All variations, including an eight-amino-acid deletion, were located between domains delta-C and II and between domains III and I, suggesting that these specific residues are not involved in enzymatic functions. 相似文献
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冰片微粉化的实验研究 总被引:3,自引:0,他引:3
通过传统研磨、加液研磨及微晶化三种方法制得的冰片在微粉学特征方面的比较,得到在一定条件下的微晶化法优于其它两种方法,效果较为理想。 相似文献
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Unrelated matched versus autologous transplantation in adult patients with good and intermediate risk acute myelogenous leukemia in first molecular remission 下载免费PDF全文
Norbert‐Claude Gorin Myriam Labopin Thomas Pabst Peter Remenyi Depei Wu Anne Huynh Liisa Volin Jean Yves Cahn Ibrahim Yakoub‐Agha Melanie Mercier Mohamed Houhou Mohamad Mohty Arnon Nagler 《American journal of hematology》2017,92(12):1318-1323
Patients with Acute Myelogenous Leukemia have a better outcome if reaching molecular remission. We compared the outcome of 373 patients autografted and 335 patients allografted with a 10/10 compatible unrelated donor in first molecular remission. Patients were stratified using the ELN European Leukemia Net classification. ELN favorable group : (234 auto and 70 unrelated transplants). By univariate analysis, in the auto group, the Non Relapse Mortality (NRM) was lower (3.7% versus 19%; P < 10?4), Relapse Incidence (RI) higher (29% versus 17%, P < 10?4), Leukemia Free Survival (LFS) identical (67% versus 64%) and Overall Survival (OS) better than in the allogeneic group (83% versus 62%; P = .008). By multivariate analysis, autologous transplantation was associated with a lower NRM (HR: 4, P = .01) and a better OS (HR: 2.08, P = .04). ELN intermediate group 1 : (87 autologous and 172 unrelated transplants). By univariate analysis, in the auto group, NRM was lower (2.5% versus 11.8%; P = .03), RI higher (59% versus 18%, P < 10?6), LFS lower (39% versus 70%; P < 10?6) and OS lower than in the unrelated donor group (61% versus 74%; P = .005). By multivariate analysis, unrelated donor was superior to autologous transplantation for LFS (HR: 0.36, P < 10?5) and OS (HR: 0.53, P = .01). ELN intermediate group 2 : (52 autologous and 93 unrelated donors). The outcome was identical. We conclude that good risk patients get higher benefit from autologous transplantation. Intermediate risk 2 patients have the same outcome and Intermediate risk 1 patients get higher benefit from unrelated donor transplants. 相似文献
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Characterization and clinical evaluation of CD10+ stroma cells in the breast cancer microenvironment
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Djabaria Na?ma Meroufel Sounnia Mediene-Benchekor Sarah A?cha Lardjam-Hetraf Hadjira Ouha?bi-Djellouli Houssam Boulenouar Imane Hamani-Medjaoui Xavier Hermant Nadhira Sa?di-Mehtar Philippe Amouyel Le?la Houti Aline Meirhaeghe Louisa Goumidi 《International journal of clinical and experimental pathology》2015,8(6):7358-7363
Genome-wide association studies have identified many lipid-associated loci primarily in European and Asian populations. In view of the differences between ethnic groups in terms of the frequency and impact of these variants, our objective was to evaluate the relationships between eight lipid-associated variants (considered individually and in combination) and fasting serum triglyceride, total cholesterol, HDL- and LDL-cholesterol levels in an Algerian population sample (ISOR study, n = 751). Three SNPs (in SORT1, CETP and GCKR) were individually associated with lipid level variations. Moreover, the risk allele scores for total cholesterol, triglyceride and LDL-C levels (encompassing between three and six SNPs) were associated with their corresponding lipid traits. Our study is the first to show that some of the lipid-associated loci in European populations are associated with lipid traits in Algerians. Although our results will have to be confirmed in other North African populations, this study contributes to a better understanding of genetic susceptibility to lipid traits in Algeria. 相似文献
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Quentin Le Hingrat Donia Bouzid Christophe Choquet Odile Laurent FranoisXavier Lescure JeanFranois Timsit Nadhira HouhouFidouh Enrique Casalino JeanChristophe Lucet Diane Descamps Benoit Visseaux 《Influenza and other respiratory viruses》2021,15(4):425
ObjectivesOur work assessed the prevalence of co‐infections in patients with SARS‐CoV‐2.MethodsAll patients hospitalized in a Parisian hospital during the first wave of COVID‐19 were tested by multiplex PCR if they presented ILI symptoms.ResultsA total of 806 patients (21%) were positive for SARS‐CoV‐2, 755 (20%) were positive for other respiratory viruses. Among the SARS‐CoV‐2‐positive patients, 49 (6%) had viral co‐infections. They presented similar age, symptoms, except for fever (P = .013) and headaches (P = .048), than single SARS‐CoV‐2 infections.ConclusionsSARS‐CoV‐2‐infected patients presenting viral co‐infections had similar clinical characteristics and prognosis than patients solely infected with SARS‐CoV‐2. 相似文献
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