全文获取类型
收费全文 | 74篇 |
免费 | 0篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 4篇 |
妇产科学 | 1篇 |
基础医学 | 10篇 |
口腔科学 | 2篇 |
临床医学 | 7篇 |
内科学 | 14篇 |
皮肤病学 | 1篇 |
神经病学 | 2篇 |
外科学 | 4篇 |
综合类 | 2篇 |
预防医学 | 6篇 |
眼科学 | 3篇 |
药学 | 5篇 |
中国医学 | 4篇 |
肿瘤学 | 7篇 |
出版年
2024年 | 1篇 |
2023年 | 2篇 |
2022年 | 1篇 |
2021年 | 8篇 |
2020年 | 4篇 |
2019年 | 2篇 |
2018年 | 3篇 |
2017年 | 1篇 |
2016年 | 1篇 |
2014年 | 2篇 |
2013年 | 3篇 |
2012年 | 8篇 |
2011年 | 8篇 |
2010年 | 1篇 |
2009年 | 4篇 |
2008年 | 6篇 |
2007年 | 6篇 |
2006年 | 2篇 |
2005年 | 2篇 |
2004年 | 2篇 |
2003年 | 6篇 |
1990年 | 1篇 |
排序方式: 共有74条查询结果,搜索用时 15 毫秒
1.
Kavitha Kothur Subhash Kaul S. Rammurthi V. C. S. Srinivasarao Bandaru Suvarna Alladi T. Suryaprabha K. Rukmini Mrudula 《Annals of Indian Academy of Neurology》2012,15(1):35-38
Cerebral venous thrombosis developing concurrently with active ulcerative colitis poses a therapeutic dilemma. We report the case of a 31-year-old woman who developed dural venous sinus thrombosis during the course of active ulcerative colitis in whom we accomplished clot lysis using intrasinus urokinase. The success of the procedure was assessed by improvement in the patient''s neurological condition and resolution of imaging features without any bleeding complications. We also reviewed literature on various modalities of treatment of sinus venous thrombosis in patients with ulcerative colitis and outcome. 相似文献
2.
Mrudula Varanat Ricardo G. Maggi Keith E. Linder Edward B. Breitschwerdt 《Medical microbiology and immunology》2013,202(2):143-151
Angiogenesis is an important physiological and pathological process. Bartonella is the only genus of bacteria known to induce pathological angiogenesis in the mammalian host. Bartonella-induced angiogenesis leads to the formation of vascular tumors including verruga peruana and bacillary angiomatosis. The mechanism of Bartonella-induced angiogenesis is not completely understood. Pericytes, along with endothelial cells, play an important role in physiological angiogenesis, and their role in tumor angiogenesis has been extensively studied. Abnormal signaling between endothelial cells and pericytes contributes to tumor angiogenesis and metastasis; however, the role of pericytes in Bartonella-induced angiogenesis is not known. In this study, after infecting human brain vascular pericytes (HBVPs) with Bartonella henselae, we found that these bacteria were able to invade HBVPs and that bacterial infection resulted in decreased pericyte proliferation and increased pericyte production of vascular endothelial growth factor (VEGF) when compared to the uninfected control cells. In the context of pathological angiogenesis, reduced pericyte coverage, accompanied by increased VEGF production, may promote endothelial cell proliferation and the formation of new vessels. 相似文献
3.
Jakkula M Boucher TA Beyendorff U Conn SM Johnson JE Nolan CJ Peine CJ Albrecht JH 《Archives of internal medicine》2004,164(12):1341-1346
BACKGROUND: Many patients with the hepatitis C virus (HCV) cannot be successfully treated with interferon-based regimens. Chinese herbal medicines have been widely prescribed for HCV in Asia, and many infected patients in the United States have used these agents. However, data to support the efficacy of these medications are limited and, to our knowledge, no published trials have been conducted in a US population. METHODS: In a double-blinded design, 45 patients with HCV and fatigue were randomized to receive a combination of Chinese herbal medications or a matched placebo for 12 weeks. The main outcome measures were changes in health-related quality of life using the role physical and vitality scale scores from the validated Hepatitis Quality of Life Questionnaire and alanine aminotransferase levels. In addition, other Hepatitis Quality of Life Questionnaire variables, HCV load, and adverse effects were monitored. RESULTS: In patients with HCV, the herbal medications had no effect on any quality-of-life variables, as measured by the Hepatitis Quality of Life Questionnaire. In addition, no significant changes in alanine aminotransferase or serum HCV RNA levels were noted. No significant adverse effects were observed. CONCLUSIONS: In this study, a regimen of Chinese herbal medicines did not improve quality of life, liver chemistry results, or viral load in a cohort of patients with HCV. Patients and practitioners should remain cautious about the use of herbal medicines for HCV, because studies have not shown a clear benefit of these agents. 相似文献
4.
Metta Vinod Leta Valentina Mrudula Kandadai Rukmini Prashanth L. K. Goyal Vinay Borgohain Rupam Chung-Faye Guy Chaudhuri K. Ray 《Journal of neurology》2022,269(3):1154-1163
Journal of Neurology - Gastrointestinal symptoms and gut dysbiosis may occur before the onset of motor symptoms in Parkinson's disease (PD). Prediagnostic and prodromal features, such as... 相似文献
5.
Madhulika Arutla Subhaleena Sarkar Misbah Unnisa Priyanka Sarkar Merlin Annie Raj M.R. Mrudula Deepika G Sudhir Pasham Aparna Jakkampudi Ambika Prasanna D. Nageshwar Reddy Rupjyoti Talukdar 《Pancreatology》2021,21(1):34-41
BackgroundRCTs that have shown improvement in coefficient of fat absorption with pancreatic enzyme replacement therapy (PERT) have seldom evaluated the impact on overall nutritional status.ObjectiveIn this study we evaluated factors responsible for persistence of malnutrition after PERT.MethodsIn this cross-sectional observational study, patients were enrolled based on predefined enrolment criteria. Patients were divided into those taking PERT regularly (Group A), irregularly (Group B) and not taking (Group C) for at least 3 months. Comprehensive evaluation of anthropometric measurements, nutritional assessment and dietary intake was performed. Malnutrition was measured using the Subjective Global Assessment (SGA) tool. Relationship between PERT status, dietary intake and nutritional status were evaluated using standard statistical methods. Logistic regression was performed to identify factors associated with persistence of malnutrition after PERT.Results377 patients with CP and 50 controls were included. 95 (25.2%) patients with CP were in Group A, 106 (28.1%) in Group B and 176 (46.7%) in Group C. 130 (34.5%) patients were malnourished, of which 76 (58.5%) were continuing PERT. There were no differences in clinical and biochemical nutritional markers between Groups A, B, and C. Calorie deficit and daily intake of calorie, protein, carbohydrates and fats were not different between those with and without PERT, but was significantly less in those with malnutrition. Logistic regression demonstrated inadequate dietary intake as independent risk factor for persistence of malnutrition.ConclusionEven though PERT is effective in PEI, comprehensive nutritional assessment, personalized nutritional counselling and therapy along with PERT is mandatory. 相似文献
6.
Aim of the study
This study investigated effect of a crude extract of Dodonaea viscosa on the proteinase and phospholipase production and adherence to epithelial cells by Candida albicans isolated from HIV positive and HIV negative patients.Materials and methods
Twenty Candida albicans strains isolated from HIV positive and 20 from HIV negative patients were investigated. The isolates were exposed to subinhibitory concentration of crude plant extract and adherence, proteinase and phospholipase production were assessed. The results were analysed using Student's t-test and a two-way ANOVA.Results
Dodonaea viscosa var. angustifolia inhibited the adherence of Candida albicans to oral epithelial cells (p = <0.01) but no significant effect of the plant extract on proteinase and phospholipase production was observed. Results from Candida albicans strains isolated from HIV positive and HIV negative patients were similar.Conclusions
Dodonaea viscosa var. angustifolia inhibited the adherence of Candida albicans to oral epithelial cells, which is the initial step of colonization in the infection process. This plant has a therapeutic potential at subinhibitory concentration. 相似文献7.
AbstractThe ethanol extract of Dalbergia lanceolaria. Linn. bark was subjected to pharmacological screening using various animal models. The extract showed analgesic activity when tested in acetic acid–induced writhing, tail-flick response, and formalin-induced licking tests in Swiss albino mice. The plant extract, at doses of 100, 200, and 400 mg/kg body weight, showed significant central as well as peripheral analgesic activity by oral route. Therefore, the current study indicates that the ethanol extract of Dalbergia lanceolaria. bark has significant central and peripheral analgesic activity. 相似文献
8.
9.
Type 2 diabetes prevalence is rising rapidly in developing world especially in India in last few decades. ‘Thrifty phenotype’ and ‘westernization of lifestyle’ is used to explain this epidemic. Chromium is an important modulator in insulin and glucose metabolism. Preconceptional chromium exposure has been demonstrated to raise the corticosterone and glucose levels in offspring of rodent model. Chromium is chelated when acidic food is stored in the stainless steel utensils. Chromium levels are shown to be high in Asian Indians. The hyperinsulinemia and insulin resistance is demonstrated in Indians from the newborn stage. We hypothesize that increased exposure to chromium in preconceptional and/or fetal stage leads to altered epigenetic control and altered endocrine and metabolic functioning. Increasing urbanization has led to increasing use of stainless steel and resultant exposure to chromium is at the least partly responsible for rising prevalence of type 2 diabetes. If proven avoiding or modifying the use of stainless steel utensils will halt the present epidemic of type 2 diabetes. 相似文献
10.
Edward B. Breitschwerdt Ricardo G. Maggi Mrudula Varanat Keith E. Linder Guy Weinberg 《Journal of clinical microbiology》2009,47(6):1957-1960
In this report, we describe isolation of Bartonella vinsonii subsp. berkhoffii genotype II from a boy with epithelioid hemangioendothelioma and a dog with hemangiopericytoma. These results suggest that B. vinsonii subsp. berkhoffii may cause vasoproliferative lesions in both humans and dogs. 相似文献