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排序方式: 共有382条查询结果,搜索用时 15 毫秒
1.
Alternating current stimulation of the eye generates an occipital electrically evoked response (a.c.-e.e.r.) of which the frequency characteristic shows a monophasic pattern for which the optimum stimulus frequency for evoking a maximum response is 18 Hz. A.C.-E.E.R. is a very useful tool for making a diagnosis of pigmentary retinal dystrophy and is different from the e.r.g. in that it is not affected by diseases of the optical system such as strong refractive anomalies or vitreous opacities. 相似文献
2.
Karin Ishikawa Tomihiko Tanino Yuichiro Ohtake Itaru Kimura Hiroshi Miyata Yukihiko Mashima 《Japanese journal of ophthalmology》2004,48(1):90-91
Purpose To review the outcome of surgery for strabismus due to ethmoid sinus surgery.Cases and Methods The series comprised 13 cases, 1 of inferior rectus paresis, 1 of superior oblique paresis, 6 of medial rectus paresis, and 5 of medial rectus muscle palsy due to third nerve palsy. In the cases of paresis of the rectus muscle, resection of the rectus muscles was mainly performed. In the cases of palsy of the rectus muscle, transposition of the extraocular muscle with simultaneous recession of the lateral rectus muscle was performed. The major aim of surgery was to bring both eyes into alignment and to eliminate diplopia in the primary position.Results The mean preoperative horizontal deviation of 18.1 degrees of exotropia in the paresis cases was reduced to 1.4 degrees of exotropia after surgery. The mean preoperative vertical deviation of 3.8 degrees of hypertropia was reduced to 1.4 degrees of hypertropia postoperatively. The mean preoperative horizontal deviation of 35.6 degrees of exotropia in the palsy cases was reduced to 9.4 degrees of exotropia after surgery. The mean preoperative vertical deviation of 2.0 degrees of hypertropia was increased to 2.6 degrees of hypertropia postoperatively. Postoperatively, diplopia was absent in 11 cases with a slightly compensatory head posture.Conclusions Surgery for strabismus due to sinus surgery induces improvements in eye position and diplopia.
Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc 107:425–432, 2003) 相似文献
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Huihui Xiang Yujiro Toyoshima Weidong Shen Xiangdong Wang Naoki Okada Shuhei Kii Ko Sugiyama Toshihiro Nagato Hiroya Kobayashi Kazuho Ikeo Shinichi Hashimoto Mishie Tanino Akinobu Taketomi Hidemitsu Kitamura 《Cancer science》2022,113(8):2513
Neurokinin 2 receptor (NK2R), a G protein‐coupled receptor for neurokinin A (NKA), a tachykinin family member, regulates various physiological functions including pain response, relaxation of smooth muscle, dilation of blood vessels, and vascular permeability. However, the precise role and regulation of NK2R expression in cancer cells have not been fully elucidated. In this study, we found that high NK2R gene expression was correlated with the poor survival of colorectal cancer patients, and Interferon (IFN‐α/β) stimulation significantly enhanced NK2R gene expression level of colon cancer cells in a Janus kinas 1/2 (JAK 1/2)‐dependent manner. NKA stimulation augmented viability/proliferation and phosphorylation of Extracellular‐signal‐regulated kinase 1/2 (ERK1/2) levels of IFN‐α/β‐treated colon cancer cells and NK2R blockade by using a selective antagonist reduced the proliferation in vitro. Administration of an NK2R antagonist alone or combined with polyinosinic‐polycytidylic acid, a synthetic analog of double‐stranded RNA, to CT26‐bearing mice significantly suppressed tumorigenesis. NK2R‐overexpressing CT26 cells showed enhanced tumorigenesis and metastatic colonization in both lung and liver after the inoculation into mice. These findings indicate that IFN‐α/β‐mediated NK2R expression is related to the malignancy of colon cancer cells, suggesting that NK2R blockade may be a promising strategy for colon cancers. 相似文献
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Shimpei Yamada Ken Tomida Genichi Tanino Akira Suzuki Kenji Kawakami Shinji Kubota Ryuzo Yanohara Youhei Katoh Yosuke Wada Toshio Teranishi Abbas Orand Yutaka Tomita Shigeru Sonoda 《Journal of Physical Therapy Science》2015,27(4):1247-1250
[Purpose] The purpose of this study was to find whether a fast treadmill gait training
speed is effective for the gait training of stroke patients in the early rehabilitation
stage. [Subjects and Methods] Thirty-nine stroke patients were the subjects of our
investigation. They walked on a treadmill with handrail supports at a fast speed (130% of
their comfortable gait speed in the 2nd week). The treadmill gaits of the patients were
recorded using a 3-dimensional analysis system at two and six weeks after their
admissions. Intraclass Correlation Coefficients (ICC) of the temporal and spatial
parameters of the two periods were statistically analyzed. [Results] For all of the
patients, the ICCs of the measured parameters were greater than 0.58. In the case of
patients whose gait speeds of the two periods were close, the ICC units were greater than
0.7. [Conclusion] The fast gait speed training allowed us to expose the patients to a gait
speed that they were expected to acquire at a later stage of their rehabilitation. This
training method was found to be beneficial for the mildly paralyzed patients.Key words: Stroke, Treadmill, Fast speed 相似文献
7.
Makoto Saito Masaya Miyazaki Mishie Tanino Shinya Tanaka Kencho Miyashita Koh Izumiyama Akio Mori Tatsuro Irie Masanori Tanaka Masanobu Morioka Eriko Tsukamoto 《World journal of gastroenterology : WJG》2014,20(17):5141-5146
Multiple lymphomatous polyposis(MLP)is an uncommon type of gastrointestinal lymphoma characterized by the presence of multiple polyps along the gastrointestinal tract.Most of this entity is in fact considered the counterpart of gastrointestinal tract involvement for mantle cell lymphoma(MCL).To our knowledge,there have been no reports on[fluorine-18]-fluorodeoxy-glucose(18F-FDG)-positron emission tomography(PET)/computed tomography(CT)imaging for gastrointestinal MCL with MLP.We present the results of 18F-FDG PET/CT imaging in a patient with gastrointestinal tract involvement of MCL showing continuous MLP from the stomach to the rectum and intestinal intussusception.FDG-PET/CT findings were false negative in typical MLP spreading widely over the gastrointestinal tract,but uptake was noted in large lesions with deep infiltration considered atypical as MLP.On FDG-PET/CT imaging,the Ki-67proliferative index,which is a cell proliferation marker,showed neither correlation with the presence of uptake nor the maximum standardized uptake value. 相似文献
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Mimura T Amano S Nagahara M Oshika T Tsushima K Nakanishi N Tanino T 《American journal of ophthalmology》2002,133(5):699-700
PURPOSE: To report a case with corneal endotheliitis and idiopathic sudden sensorineural hearing loss, in which herpes simplex virus type 1 DNA was demonstrated in the trabeculum and the aqueous humor by polymerase chain reaction. DESIGN: Interventional case report. METHODS: A 60-year-old man presented with corneal stromal edema in the right eye and sudden bilateral sensorineural hearing loss. The trabeculum excised during trabeculectomy and the aqueous humor were examined for the presence of herpes simplex virus type 1 DNA by polymerase chain reaction. RESULTS: Polymerase chain reaction demonstrated herpes simplex virus type 1 DNA in the aqueous humor and the trabeculum. CONCLUSION: Herpes simplex virus type 1 may cause corneal endotheliitis and idiopathic sudden sensorineural hearing loss simultaneously. 相似文献
10.
In order to quantitatively investigate the importance of transfollicular pathway for drug delivery, drug penetration through human scalp skin was investigated using liquid formulations containing lipophilic and hydrophilic drugs in vitro. The penetration pathway for drugs through the scalp skin was examined using fluorescent probes. Additionally, the drug penetration through the scalp skin was compared with that via human abdominal skin to clarify the usefulness of intrafollicular delivery. Lipophilic melatonin (MT) and ketoprofen (KP) showed high permeabilities through the scalp skin, although the flux of KP was much higher. Absorption enhancers, N-methyl-2-pyrrolidone and isopropylmyristate, only slightly increased the fluxes. Hydrophilic fluorouracil (5FU) and acyclovir (ACV) penetrated through the scalp skin with relatively large fluxes. However, there was large variability in the fluxes of these drugs across scalp skin from different sources. When the relationship between the flux and hair follicle density was estimated, there was good correlation between the two (r = 0.651 for MT and r = 0.666 for ACV, P < 0.05). The histologic examination of the scalp skin, following application of the formulation with nile red or sodium fluorescein, indicated that the probes permeated into the junction of the internal and external root sheath of follicles and diffused into the dermis via the outer root sheath at the initial times. The penetration of nile red, a lipophilic probe, via the stratum corneum of scalp skin was later than that via the follicles. The permeation of MT and 5FU through the scalp skin was much higher than that via the abdominal skin, being 27 and 48 times as high as the abdominal skin, respectively. These results indicate that the drug delivery through the scalp skin will offer an available delivery means for drugs, particularly for hydrophilic drugs. 相似文献