全文获取类型
收费全文 | 3060篇 |
免费 | 167篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 68篇 |
妇产科学 | 94篇 |
基础医学 | 408篇 |
口腔科学 | 91篇 |
临床医学 | 256篇 |
内科学 | 750篇 |
皮肤病学 | 73篇 |
神经病学 | 275篇 |
特种医学 | 119篇 |
外科学 | 392篇 |
综合类 | 21篇 |
预防医学 | 133篇 |
眼科学 | 111篇 |
药学 | 180篇 |
中国医学 | 12篇 |
肿瘤学 | 240篇 |
出版年
2023年 | 36篇 |
2022年 | 29篇 |
2021年 | 84篇 |
2020年 | 48篇 |
2019年 | 61篇 |
2018年 | 92篇 |
2017年 | 65篇 |
2016年 | 79篇 |
2015年 | 75篇 |
2014年 | 98篇 |
2013年 | 120篇 |
2012年 | 185篇 |
2011年 | 235篇 |
2010年 | 126篇 |
2009年 | 95篇 |
2008年 | 164篇 |
2007年 | 201篇 |
2006年 | 190篇 |
2005年 | 169篇 |
2004年 | 159篇 |
2003年 | 173篇 |
2002年 | 135篇 |
2001年 | 35篇 |
2000年 | 49篇 |
1999年 | 46篇 |
1998年 | 25篇 |
1997年 | 16篇 |
1996年 | 17篇 |
1995年 | 17篇 |
1994年 | 12篇 |
1993年 | 14篇 |
1992年 | 26篇 |
1991年 | 23篇 |
1990年 | 32篇 |
1989年 | 32篇 |
1988年 | 35篇 |
1987年 | 34篇 |
1986年 | 21篇 |
1985年 | 36篇 |
1984年 | 24篇 |
1983年 | 14篇 |
1982年 | 9篇 |
1981年 | 7篇 |
1979年 | 15篇 |
1978年 | 16篇 |
1977年 | 9篇 |
1975年 | 6篇 |
1972年 | 5篇 |
1969年 | 8篇 |
1968年 | 6篇 |
排序方式: 共有3240条查询结果,搜索用时 78 毫秒
1.
Madoka Minoguchi Nobuyuki Yanagawa Chisato Ishikawa Junpei Sasajima Mitsuru Goto Miho Okamoto Yoshinori Saito Masanori Murakami Yutaka Orii Toru Yaosaka 《Nihon Shokakibyo Gakkai zasshi》2007,104(7):1082-1087
Pancreatic metastasis of malignant melanoma is rarely diagnosed while the patient is alive. We report a case of metastatic melanoma of the pancreas in a 35-year-old woman presenting with a solid mass of the pancreas. Her past medical history included a radical hysterectomy 2 years previously for malignant melanoma of the vagina. Twelve months later, lung metastasis was also resected. EUS-guided fine needle aspiration (EUS-FNA) identified that the pancreatic tumor was histologically and immunohistochemically identical to the surgical specimen of her lung neoplasm. Imaging studies including US, CT, and MRI have limited value to distinguish the tumors from primary ductal adenocarcinoma. EUS-FNA can provide tissue diagnosis from pancreatic masses, specifically when other modalities have failed. 相似文献
2.
3.
Fumio Yamauchi Yoshihiro Takebayashi Takaya Abe Toshinari Muramatsu Rika Murakami Masaki Ohtsuka Masayuki Endoh Yasuo Nomoto Hideto Sakai Miho Hida 《Clinical and experimental nephrology》1997,1(3):243-246
A 52-year-old woman who had had 6 months of chemotherapy using mitomycin C and cisplatin for cervical cancer presented with
hemolytic uremic syndrome. Conventional plasmapheresis using whole-plasma fraction was ineffective. However, plasmapheresis
using the cryosupernatant fraction dramatically improved symptoms of hemolytic anemia and thrombocytopenia in this case. The
activity of factor VIII in the cryosupernatant fraction of plasma as a replacement fluid decreased after removal of cryoprecipitate,
indicating effective removal of von Willebrand factor. The pathogenesis of her hemolytic uremic syndrome may have been associated
with von Willebrand factor multimers contained in the cryoprecipitate of plasma. Similar use of the cryosupernatant fraction
of plasma could not be found in other reports of cases of hemolytic uremic syndrome. Plasmapheresis using the cryosupernatant
fraction of plasma may improve refractory hemolytic uremic syndrome. 相似文献
4.
5.
6.
A Kitami K Suzuki G Hori T Akizawa M Narushima E Noguchi Y Iida F Sagawa 《Nihon Kyōbu Shikkan Gakkai zasshi》1991,29(11):1505-1508
A 66-year-old woman visited our hospital for further investigation of a coin-shaped lesion in the right lower lung field. After admission, CT-scan revealed an anterior mediastinal tumor. Thymoma and lung metastasis from thymoma were suspected. At thoracotomy, an invasive thymoma involving the left phrenic nerve, the left upper lobe, and the pericardium was found, and the diagnosis of lung metastasis was made. Postoperative pathological findings showed a predominantly lymphocytic thymoma with round and oval-shaped epithelial cells, and the metastatic lung lesion revealed the same findings. Postoperative radiotherapy (4000 rads) and chemotherapy with a combination of CDDP, VDS, and CPA were administered. The metastasis of thymoma is not rare, but most often it is found after operation. In this case the diagnosis of metastatic thymoma was made pre-operatively from a solitary lung lesion. 相似文献
7.
Yasushi NAKAGAWA Shinobu TSUKAMOTO Miho MIYAZAKI Chiyuki NAKAGAWA Takeharu YAMANAKA Norifumi YAMASHITA Akito NOHTOMI 《Psychogeriatrics》2003,3(3):104-108
Background: In Japan a new long‐term care insurance (LTCI) system, the so‐called ‘Kaigo‐Hoken’, was started in April 2000. The present study analyzes the change in the type of destination after discharge from a senile dementia therapy ward before and after the implementation of LTCI at Fukuoka Prefectural Onga Hospital, Japan. Methods: The present study examines data from 199 inpatients discharged from the Fukuoka Prefectural Onga Hospital that had been diagnosed with dementia and met the DSM IV criteria for Alzheimer's type, vascular dementia or other type of dementia. For the purposes of comparison two periods were defined, ‘the first period’ was defined as the period from 1 April 1999 to 31 March 2000, before LTCI was implemented, while ‘the second period’ was defined as the period from 1 April 2000 to 31 March 2001, after LTCI had started. Subject data was analyzed on the basis of where the subject had resided pre‐admission and their destination after discharge using the following classifications: nursing home or geriatric care facility, hospitalization, home and death. Results: While the certification rate of inpatients regarding long‐term care increased slightly in the second period, no significant change was observed based on where the subject had resided pre‐admission and their destination after discharge between the first and second periods. Conclusions: While LTCI is essential for Japan, it is necessary that people with dementia in senile dementia therapy wards are encouraged to return to their homes under the care and support of LTCI. 相似文献
8.
Shinichiro Maeshima Jun Tanemura Aiko Osawa Miho Kawarada Eri Sekiguchi Toru Itakura 《Brain and nerve》2006,58(3):207-211
To investigate the usefulness of the frontal assessment battery (FAB) as a brief assessment for diagnosis in patients with dementia, we examined cognitive function using the FAB, Mini-mental state examination (MMSE), Kana-hiroi test, and Raven's colored progressive matrices (RCPM). Subjects were 82 senile patients having amnesia as a complaint including 28 Alzheimer's disease (AD), 14 frontotemporal dementia (FTD), 17 vascular dementia (VD), 13 mild cognitive impairment (MCI), and 10 healthy persons. We discussed the difference of scores in different types of dementia. In the FAB, the scores of healthy persons and MCI were much higher compared with the scores of all types of dementia. There were high correlation between FAB and MMSE, Kana-hiroi test, and RCPM. Although some subjects showed normal score in MMSE and/or RCPM, they showed low score in FAB. Based on this, FAB is efficient for the differential diagnosis of dementia as brief screening tool. 相似文献
9.
10.
Antimetastatic Activity of Polymeric RGDT Peptides Conjugated with Poly(ethylene glycol) 总被引:1,自引:0,他引:1
Ikuo Saiki Junya Yoneda Yu Igarashi Miho Aoki Naoto Kusunose Kei-ichi Ono Ichiro Azuma 《Cancer science》1993,84(5):558-565
Polymeric peptides containing defined repetitive or cyclic structures of RGDT sequence, (RGDT)n (n = 1 to 11) and cyclo(RGDT)n (n=2 to 4), at a dose of 500 μg exhibited an inhibitory effect on experimental lung metastasis upon co-injection with tumor cells and the magnitude of the effect increased in parallel with the increase of degree of repetition of the RGDT sequence. The conjugation of (RGDT)n (n = 1, 5, 11) with poly(ethylene glycol), PEG as a polymeric carrier led to enhanced inhibition of lung metastasis in proportion to the degree of RGDT sequence repetition and in a dose-dependent manner. Multiple i.v. administrations of PEG-(RGDT)11, at 2-day and 3-day intervals before the excision of primary tumors, effectively inhibited spontaneous lung metastasis by s.c. inoculation of tumors, whereas (RGDT)11 exhibited inhibition of lung metastasis only when given at 2-day intervals. This indicates that the conjugation of PEG with (RGDT)n allowed the prolongation of administration interval, implying a sustained inhibitory effect on tumor metastasis. In support of this supposition, a decrease in the arrest of radiolabeled tumor cells in the lungs was observed when PEG-(RGDT)11 was co-injected i.v. with tumor cells, or injected i.v. one day before tumor inoculation. In contrast, (RGDT)11 significantly inhibited the tumor cell arrest in the lungs only upon co-injection with tumor cells. We also noted that (RGDT)n, cyclo(RGDT)n and PEG-(RGDT)11 inhibited tumor cell invasion into Matrigel in a concentration-dependent manner and in proportion to the degree of RGDT sequence repetition, indicating that the peptide-mediated antimetastatic effect is partly associated with the anti-invasive potential. Thus, the conjugation of anti-cell adhesive and antimetastatic RGDT peptide with PEG might provide a therapeutically promising basis for the prevention of cancer metastasis (“anti adhesion therapy”). 相似文献