全文获取类型
收费全文 | 17461篇 |
免费 | 614篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 921篇 |
儿科学 | 520篇 |
妇产科学 | 1176篇 |
基础医学 | 2156篇 |
口腔科学 | 149篇 |
临床医学 | 960篇 |
内科学 | 3605篇 |
皮肤病学 | 251篇 |
神经病学 | 1908篇 |
特种医学 | 306篇 |
外科学 | 1291篇 |
综合类 | 38篇 |
一般理论 | 1篇 |
预防医学 | 1240篇 |
眼科学 | 562篇 |
药学 | 2437篇 |
中国医学 | 37篇 |
肿瘤学 | 549篇 |
出版年
2023年 | 86篇 |
2022年 | 61篇 |
2021年 | 168篇 |
2020年 | 143篇 |
2019年 | 264篇 |
2018年 | 583篇 |
2017年 | 411篇 |
2016年 | 426篇 |
2015年 | 380篇 |
2014年 | 621篇 |
2013年 | 923篇 |
2012年 | 1118篇 |
2011年 | 1411篇 |
2010年 | 710篇 |
2009年 | 327篇 |
2008年 | 885篇 |
2007年 | 1243篇 |
2006年 | 1323篇 |
2005年 | 1266篇 |
2004年 | 1320篇 |
2003年 | 1313篇 |
2002年 | 1070篇 |
2001年 | 465篇 |
2000年 | 512篇 |
1999年 | 300篇 |
1998年 | 105篇 |
1997年 | 27篇 |
1996年 | 20篇 |
1995年 | 21篇 |
1994年 | 14篇 |
1993年 | 13篇 |
1992年 | 19篇 |
1991年 | 15篇 |
1990年 | 38篇 |
1989年 | 13篇 |
1988年 | 21篇 |
1987年 | 22篇 |
1986年 | 26篇 |
1985年 | 32篇 |
1984年 | 22篇 |
1983年 | 25篇 |
1982年 | 23篇 |
1981年 | 33篇 |
1980年 | 23篇 |
1979年 | 22篇 |
1978年 | 25篇 |
1977年 | 19篇 |
1976年 | 15篇 |
1975年 | 21篇 |
1974年 | 14篇 |
排序方式: 共有10000条查询结果,搜索用时 343 毫秒
1.
Agata Cieślik-Bielecka Paweł Reichert Rafał Skowroński Tomasz Bielecki 《Platelets》2019,30(6):728-736
The current literature suggests that the antibacterial effect of leukocyte- and platelet-rich plasma (L-PRP) is directly related to platelet and leukocyte concentrations. The aim of this study was twofold: first, to evaluate the antimicrobial effect of L-PRP against selected bacterial strains in vitro, and second, to correlate this effect with leukocyte and platelet content in the final concentration. Blood was collected from 20 healthy males, and L-PRP, acellular plasma (AP), and autologous thrombin were consecutively prepared. Flow cytometry analysis of the blood, L-PRP, and AP was performed. The L-PRP gel, liquid L-PRP, and thrombin samples were tested in vitro for their antibacterial properties against seven selected bacterial strains using the Kirby–Bauer disk-diffusion method. There was notable antimicrobial activity against selected bacterial strains. No statistically significant correlations between antimicrobial activities and the platelet concentration in L-PRP were observed. Statistically significant positive correlations between selected leukocyte subtypes and antimicrobial activity were noted. A negative correlation was found between elevated monocyte count and antimicrobial activity of L-PRP against one bacterial strain studied. L-PRP possesses antimicrobial activity and can be potentially useful in the fight against certain postoperative infections. The bactericidal effect of L-PRP is caused by leukocytes, and there exists a relationship among selected leukocyte subtypes and L-PRP antimicrobial activity. 相似文献
2.
Inflammation but not obesity or insulin resistance is associated with increased plasma fibroblast growth factor 23 concentration in the elderly
下载免费PDF全文
![点击此处可从《Clinical endocrinology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
3.
4.
Konrad Matyja Anna Małachowska-Jutsz Anna K. Mazur Kazimierz Grabas 《Ecotoxicology (London, England)》2016,25(5):924-939
Dehydrogenase activity is frequently used to assess the general condition of microorganisms in soil and activated sludge. Many studies have investigated the inhibition of dehydrogenase activity by various compounds, including heavy metal ions. However, the time after which the measurements are carried out is often chosen arbitrarily. Thus, it can be difficult to estimate how the toxic effects of compounds vary during the reaction and when the maximum of the effect would be reached. Hence, the aim of this study was to create simple and useful mathematical model describing changes in dehydrogenase activity during exposure to substances that inactivate enzymes. Our model is based on the Lagergrens pseudo-first-order equation, the rate of chemical reactions, enzyme activity, and inactivation and was created to describe short-term changes in dehydrogenase activity. The main assumption of our model is that toxic substances cause irreversible inactivation of enzyme units. The model is able to predict the maximum direct toxic effect (MDTE) and the time to reach this maximum (TMDTE). In order to validate our model, we present two examples: inactivation of dehydrogenase in microorganisms in soil and activated sludge. The model was applied successfully for cadmium and copper ions. Our results indicate that the predicted MDTE and TMDTE are more appropriate than EC50 and IC50 for toxicity assessments, except for long exposure times. 相似文献
5.
6.
7.
8.
Micha? Panasiuk Marek Synder Maryla Drynkowska-Panasiuk Oktawiusz Bończak 《Chirurgia narzadów ruchu i ortopedia polska》2006,71(4):265-267
Serum levels of bone markers N-mid osteocalcin (OCN-Mid) and Cross-Laps in 20 patients (8 men and 12 women) with loosening of at least one element of total hip endoprosthesis confirmed during operation were compared with age and sex matched group with OA. Marker levels were measured by direct chemoluminescency using Modular E-170. Statistical analysis were done with t-Student test (alpha = 0.05). There were no significant differences in OCN-Mid, Cross-Laps levels and OCN-Mid/Cross-Laps ratio between both groups. Implant loosening is a slow process taking place on a relatively small surface in comparison to whole skeleton, so bone markers have no clinical value in diagnostics of total hip loosening. 相似文献
9.
Integration and differentiation of human embryonic stem cells transplanted to the chick embryo. 总被引:3,自引:0,他引:3
Ronald S Goldstein Micha Drukker Benjamin E Reubinoff Nissim Benvenisty 《Developmental dynamics》2002,225(1):80-86
Human embryonic stem (ES) cells are pluripotent cells that can differentiate into a large array of cell types and, thus, hold promise for advancing our understanding of human embryology and for contributing to transplantation medicine. In this study, differentiation of human ES cells was examined in vivo by in ovo transplantation to organogenesis-stage embryos. Colonies of human ES cells were grafted into or in place of epithelial-stage somites of chick embryos of 1.5 to 2 days of development. The grafted human ES cells survived in the chick host and were identified by vital staining with carboxyfluorescein diacetate or use of a green fluorescent protein-expressing cells. Histologic analysis showed that human ES cells are easily distinguished from host cells by their larger, more intensely staining nuclei. Some grafted cells differentiated en masse into epithelia, whereas others migrated and mingled with host tissues, including the dorsal root ganglion. Colonies grafted directly adjacent to the host neural tube produced primarily structures with the morphology and molecular characteristics of neural rosettes. These structures contain differentiated neurons as shown by beta-3-tubulin and neurofilament expression in axons and cell bodies. Axons derived from the grafted cells penetrate the host nervous system, and host axons enter the structures derived from the graft. Our results show that human ES cells transplanted in ovo survive, divide, differentiate, and integrate with host tissues and that the host embryonic environment may modulate their differentiation. The chick embryo, therefore, may serve as an accessible and unique experimental system for the study of in vivo development of human ES cells. 相似文献
10.
Micha? Latalski 《Chirurgia narzadów ruchu i ortopedia polska》2007,72(2):129-131
The Internet is becoming a more integral part of daily education for all orthopaedic surgeons. Author presents web sites, which are interesting resources of orthopaedic knowledge. 相似文献