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Detection of the marine toxins okadaic acid and domoic acid in shellfish and phytoplankton in the Gulf of Mexico. 总被引:5,自引:0,他引:5
Liquid chromatographic analyses of extracts from shellfish and phytoplankton from the Gulf of Mexico indicated the presence of the marine toxins okadaic acid (0.162 microgram/g shellfish) and domoic acid (2.1 pg/cell phytoplankter). These toxins are causative agents of diarrhetic shellfish poisoning (DSP) and amnesic shellfish poisoning (ASP), respectively. The presence of DSP and ASP toxins in a region with no previous record of outbreaks may indicate a potential for human poisoning under conditions appropriate for accumulation of these toxins in shellfish. 相似文献
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Itamar S. Santos Márcio S. Bittencourt Ilka R.S. Oliveira Angelita G. Souza Danilo P. Meireles Tatjana Rundek Murilo Foppa Daniel C. Bezerra Cláudia M.V. Freire Leonard H. Roelke Sayonara Carrilho Isabela M. Benseñor Paulo A. Lotufo 《Atherosclerosis》2014
Objective
Carotid intima–media thickness (IMT) is a noninvasive measurement of early atherosclerosis. Most IMT studies have involved populations with low rates of racial blending. The aim of the present article is to describe IMT value distributions and analyze the influence of sex and race on IMT values in a large Brazilian sample, a setting with a high rate of racial admixture.Methods
The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a multicenter cohort of 15,105 adult (aged 35–74 years) civil servants in six Brazilian cities. Baseline assessment included IMT measurements in both common carotid arteries. Race was self-reported. We studied the association between sex and race with IMT values using multiple linear regression models. We conducted analyses in all and low-risk individuals, defined as those without classical cardiovascular risk factors.Results
We analyzed complete IMT data from 10,405 ELSA-Brasil participants. We present nomograms by age for all and low-risk individuals, stratified by sex and race. We found that men had significantly higher maximal IMT values compared with women (β = 0.058; P < 0.001). This association remained for low-risk individuals (β = 0.027; P = 0.001). In addition, Brown and White individuals had lower maximal IMT values compared with Black individuals for all (β = −0.034 and β = −0.054, respectively; P < 0.001) and low-risk individuals (β = −0.027; P = 0.013 and β = −0.035; P < 0.001, respectively).Conclusion
We found significantly higher IMT values in men. We found significantly higher IMT values in Black individuals than White and Brown individuals. These results persisted when analyses were restricted to low-risk individuals. 相似文献5.
Common and differential chemokine expression patterns in rs cells of NLP,EBV positive and negative classical Hodgkin lymphomas 总被引:3,自引:0,他引:3
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Parsonnet V Roelke M Trivedi A Rizvi SA Pervez A 《Pacing and clinical electrophysiology : PACE》2001,24(3):329-332
Removing entrapped pacing and defibrillator leads has been greatly simplified by making use of the excimer laser extractor. Sixty-two leads were successfully removed, although where appropriate, portions of the lead remained in place in 10 cases. There were two serious complications, one tear of the superior vena cava during an ICD extraction and one tear of the atrium during an atrial lead extraction. Both were controlled successfully through emergency sternotomy. Although extracting entrapped leads has been much simplified by making use of the laser extractor, the process is not free of serious complications. Those involved in explanting leads should be aware of the outcomes and be prepared for emergent management. 相似文献
8.
Frank L. Mastaglia Merrilee Needham Adrian Scott Ian James Paul Zilko Timothy Day Lynette Kiers Alastair Corbett Campbell S. Witt Richard Allcock Nigel Laing Michael Garlepp Frank T. Christiansen 《Neuromuscular disorders : NMD》2009,19(11):763-765
Susceptibility to sIBM is strongly associated with the HLA-DRB1*03 allele and the 8.1 MHC ancestral haplotype (HLA-A1, B8, DRB1*03) but little is known about the effects of allelic interactions at the DRB1 locus or disease-modifying effects of HLA alleles. HLA-A, B and DRB1 genotyping was performed in 80 Australian sIBM cases and the frequencies of different alleles and allele combinations were compared with those in a group of 190 healthy controls. Genotype–phenotype correlations were also investigated. Amongst carriers of the HLA-DRB1*03 allele, DRB1*03/*01 heterozygotes were over-represented in the sIBM group (p < 0.003) while. DRB1*03/*04 heterozygotes were under-represented (p < 0.008). The mean age-at-onset (AAO) was 6.5 years earlier in DRB1*03/*01 heterozygotes who also had more severe quadriceps muscle weakness than the rest of the cohort. The findings indicate that interactions between the HLA-DRB1*03 allele and other alleles at the DRB1 locus can influence disease susceptibility and the clinical phenotype in sIBM. 相似文献
9.
Sarah N. Bevins Jeff A. Tracey Sam P. Franklin Virginia L. Schmit Martha L. MacMillan Kenneth L. Gage Martin E. Schriefer Kenneth A. Logan Linda L. Sweanor Mat W. Alldredge Caroline Krumm Walter M. Boyce Winston Vickers Seth P.D. Riley Lisa M. Lyren Erin E. Boydston Robert N. Fisher Melody E. Roelke Mo Salman Kevin R. Crooks Sue VandeWoude 《Emerging infectious diseases》2009,15(12):2021-2024
Plague seroprevalence was estimated in populations of pumas and bobcats in the western United States. High levels of exposure in plague-endemic regions indicate the need to consider the ecology and pathobiology of plague in nondomestic felid hosts to better understand the role of these species in disease persistence and transmission. 相似文献
10.
Adam Zimmermann Dan I. Lubman Merrilee Cox 《International journal of mental health and addiction》2012,10(5):722-736
Previous research has consistently documented high rates of tobacco smoking and substance use disorders among young people with serious mental illness. However, limited studies have been conducted outside traditional clinical settings. In an attempt to address this shortfall and to better understand the needs of young people accessing its services, a national psychiatric disability support service (Neami) examined the prevalence and impact of substance use among 120 consumers from across Australia aged 30?years and under. Results indicated extremely high rates of tobacco use, with 68% of participants identified as daily smokers. In addition, 33.4% met criteria for an alcohol use disorder, whilst 40.8% met criteria for a cannabis use disorder. Overall rates of other illicit substance use were low. This study reinforces the need for routine alcohol and drug screening and assessment across all mental health settings, as well as appropriate support strategies that address high level smoking and caffeine intake. 相似文献