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排序方式: 共有10000条查询结果,搜索用时 15 毫秒
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Alessia Scarselli Silvia Di Cesare Claudia Capponi Simona Cascioli Maria L. Romiti Gigliola Di Matteo Alessandra Simonetti Paolo Palma Andrea Finocchi Barbarella Lucarelli Rita M. Pinto Ippolita Rana Giuseppe Palumbo Maurizio Caniglia Paolo Rossi Rita Carsetti Caterina Cancrini Alessandro Aiuti 《Journal of clinical immunology》2015,35(4):373-383
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Thiazolidinediones (TZDs), agonists of the nuclear receptor peroxisome proliferator-activated receptor-γ, induce the expression
of many genes, including several enzymes and transporters involved in glucose and lipid metabolism. Although the efficacy
of TZDs on blood glucose control in type 2 diabetes is not questionable, their cardiovascular effects have been debated, with
beneficial or harmful actions suggested by different authors. This article reviews the available clinical evidence on the
cardiovascular effects of TZDs, discussing possible mechanisms underlying the observed effects and suggesting some directions
for future research. 相似文献
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Matteo Tosato Valentina Zamboni Alessandro Ferrini Matteo Cesari 《Clinical Interventions in Aging》2007,2(3):401-412
Aging is commonly defined as the accumulation of diverse deleterious changes occurring in cells and tissues with advancing age that are responsible for the increased risk of disease and death. The major theories of aging are all specific of a particular cause of aging, providing useful and important insights for the understanding of age-related physiological changes. However, a global view of them is needed when debating of a process which is still obscure in some of its aspects. In this context, the search for a single cause of aging has recently been replaced by the view of aging as an extremely complex, multifactorial process. Therefore, the different theories of aging should not be considered as mutually exclusive, but complementary of others in the explanation of some or all the features of the normal aging process. To date, no convincing evidence showing the administration of existing “anti-aging” remedies can slow aging or increase longevity in humans is available. Nevertheless, several studies on animal models have shown that aging rates and life expectancy can be modified. The present review provides an overlook of the most commonly accepted theories of aging, providing current evidence of those interventions aimed at modifying the aging process. 相似文献