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1.
2.
De Leo V; Morgante G; Lanzetta D; D'Antona D; Bertieri RS 《Human reproduction (Oxford, England)》1997,12(2):357-360
We report the results of administration of danazol after suspension of
gonadotrophin-releasing hormone analogue (GnRHa) therapy for uterine
myomas. A total of 21 women with uterine myomas was treated with 100 mg
danazol for 6 months after GnRHa therapy. Uterine volume and endocrine
status were monitored monthly by ultrasound and assay of plasma
gonadotrophins, oestradiol and progesterone. The results show a rebound of
uterine volume about 30% less than in controls at the end of danazol
therapy. Menstrual cyclicity returned after 65 +/- 3 days in 16 subjects
and five patients remained amenorrhoeic. Hormone assays confirmed renewed
ovarian function in the women whose menstrual periods returned. Bone
mineral content was substantially reduced during GnRHa treatment but
improved significantly during danazol therapy even in the women who
remained amenorrhoeic. These results show the utility of danazol in
prolonging the therapeutic effects of GnRHa. The mechanism by which danazol
inhibits rebound of uterine volume may be due to its antiprogesterone
effects on uterine myomas.
相似文献
3.
Maternal serum and amniotic fluid alpha-fetoprotein testing has increased significantly in our laboratory and throughout the state since 1985. The results of this test are reported in a novel fashion as multiples of the median. The calculation and reporting of the test results are highly dependent upon gestational age, maternal weight, race and presence or absence of maternal diabetes. When properly interpreted alpha-fetoprotein determinations are a good screening test for early detection of neural tube defects and Trisomy 21 (Down Syndrome). Our approach to screening, diagnosis and counseling is discussed. 相似文献
4.
5.
A S Loginov N G Basov V P Ambartsumian G N Sokolova E P Markin 《Terapevticheski? arkhiv》1989,61(2):42-46
A group of patients with chronic gastric ulcers received a course of laser treatment with the use of laser on copper vapours. Gastric ulcer was exposed to radiation once in the course of 5 days, the single dose being equal to 10-15 J. Complete healing of the ulcerous defect was attained in 100 out of 110 patients examined. The results of laser therapy were found to be influenced by certain clinical characteristics, namely by age, ulcer size, duration of the last disease exacerbation, and acid-secreting function of the stomach. 相似文献
6.
7.
Prior studies have shown that pneumothorax is one of the more difficult entities to diagnose with digitized radiography. This study was designed to test whether increasing resolution from 1.25 to 2.5 line pairs per millimeter (lp/mm) and image processing (edge enhancement from unsharp masking) would increase accuracy and confidence in the diagnosis of pneumothorax, as well as normal cases and other forms of lung disease. Conventional radiographs were digitized with use of a laser reader and then reformatted as film hard copy. Eleven observers read 35 cases reformatted in three different ways (1.25 lp/mm, 2.5 lp/mm, 1.25 lp/mm unsharp mask). The images with finer resolution (2.5 lp/mm) and unsharp mask images were superior to those with coarser resolution (1.25 lp/mm) for the diagnosis of pneumothorax. There was no difference in diagnostic accuracy for normal patients. For abnormalities other than pneumothorax, the unsharp mask images were significantly worse. Confidence in the diagnosis of pneumothorax and other abnormalities was highest with the finest resolution (2.5 lp/mm). 相似文献
8.
The authors report the clinical and laboratory findings of a patient who had severe immune hemolytic anemia due to hydrochlorothiazide (HCTZ). In this case, the HCTZ antibody reacted not only with other thiazide and thiazide-like drugs, but also with a chemically unrelated diuretic, ethacrynic acid. These results indicate that HCTZ antibody activity is not restricted solely to the thiazides and imply that therapy with any of the reactive drugs would be contraindicated for this patient. The serologic screening for drug reactivity may be useful for selecting alternative therapy for patients with drug-induced immune hemolytic anemia. 相似文献
9.
R. Yu. Kosenko A. L. Iordanskii V. S. Markin G. Arthanarivaran A. P. Bonartsev G. A. Bonartseva 《Pharmaceutical Chemistry Journal》2007,41(12):652-655
A polymeric system based on biocompatible and biodegradable poly(3-hydroxybutyrate) (PHB) is proposed for controlled release
of furacilin (Frc). The kinetics of Frc release from PHB membranes containing 0.5–5.0 wt% Frc into a model aqueous medium
at 25°C have been studied using a UV spectroscopy technique. The drug release profiles present a combination of diffusion
and kinetic components. The diffusion component of the release kinetics has been analyzed and the dependence of the diffusivity
on the drug concentrations has been determined. The rate constant of the release kinetics depends on the Frc concentration
and is related to the hydrolytic destruction of PHB. The PHB hydrolysis is most clearly demonstrated in long-term experiments
(after the first week of drug release). The obtained results are useful for the development of new controlled drug delivery
systems containing several drugs, which provide a combined action on tissues and organs of the organism.
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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 41, No. 12, pp. 30–33, December, 2007. 相似文献
10.
Hepatic failure associated with imipramine therapy 总被引:1,自引:0,他引:1
Imipramine, a widely used antidepressant, has rarely been associated with hepatic abnormalities. In the majority of reported cases, hepatic effects have been transient and readily reversible on discontinuation of the drug. We cared for an 11-year-old boy with hepatic failure and massive cell necrosis which followed treatment with imipramine for enuresis. This therapy led to fulminant hepatic failure and subsequent liver transplantation. 相似文献