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1.
Autologous blood as a source of platelet gel for the effective and safe treatment of oral chronic graft‐versus‐host disease
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2.
Nikolina Petru?i? Martina Posavac Ivan Sabol Marinka Mravak-Stipeti? 《Acta stomatologica Croatica》2015,49(4):309-315
Aim
The purpose of this study was to examine the detrimental effect of smoking on the function of the salivary glands.Material and Methods
The study was conducted on 60 patients who were divided into two groups: a test group which included smokers and control group represented by non-smokers. Each group included 30 patients. General information was collected from all the respondents via a questionnaire as well as the data on the duration of smoking and number of cigarettes smoked per day. Saliva was collected by spitting method in a graduated tube and the amount of unstimulated and stimulated saliva was measured and recorded in ml per minute. Stimulated saliva was collected immediately after rinsing the mouth with a 2% aqueous solution of citric acid which is carried salivary stimulation. The presence of pigmentation on the teeth and coated tongue were recorded during clinical examination. The degree of oral hygiene was determined by plaque index. All the obtained data were statistically analyzed with significance level p <0.05.Results
The results showed no significant differences in the amount of saliva between smokers and non-smokers, however, the amount of saliva decreases significantly with the duration of smoking and increasing age of smokers. Also proven was the difference in the quality of saliva: smokers have thick saliva and nonsmokers predominantly serous. In addition, smokers have poorer oral hygiene status than non-smokers, and demonstrated a positive correlation between the level of oral hygiene and length of smoking tobacco.Conclusion
This study has proven that smoking adversely affects salivation: long-term smoking reduces the secretion of saliva and changes its quality.Key words: Smoking, Tobacco Use Disorder, Saliva, Salivation, Xerostomia 相似文献3.
Baričević M Ratkaj I Mladinić M Zelježić D Kraljević SP Lončar B Stipetić MM 《Clinical oral investigations》2012,16(1):325-331
Given long-term effect on oral tissues due to contact with dental appliances, the biocompatibility studies of casting alloys
are of great importance. It has been previously documented that metal dental appliances, due to corrosion, might induce genotoxic
and mutagenic effects in cells. Therefore, the aim of presented study was to examine the genotoxicity of two dental casting
alloys (Co-Cr-Mo and Ni-Cr) commonly used in fixed and removable prosthodontic appliances that are in contact with the oral
epithelium for 5 years or more. For that purpose, 55 age-matched subjects were included in the study; 30 wearers of prosthodontic
appliances and 25 controls. Buccal cells of oral mucosa were collected and processed for further analysis. The cell viability
has been assessed by trypan blue exclusion test, while genotoxic effect of metal ions on DNA in oral mucosa cells was studied
by use of alkaline comet assay. Results have shown significantly higher comet assay parameters (tail length and percentage
DNA in the tail) in the group wearing metal appliances. Both subjects with Co-Cr-Mo alloy and Ni-Cr alloy showed significantly
higher comet assay parameters when compared with controls. It has been confirmed that metal ions released by the two base
metal dental casting alloys examined in this study, might be responsible for DNA damage of oral mucosa cells. Therefore, the
results of this study emphasize the importance of the in vivo evaluation of dental materials with respect to their genotoxicity,
which is of major importance to ensure long-term biocompatibility. 相似文献
4.
Marinka L. F. Hol Daniel J. Indelicato Olga Slater Frederic Kolb Richard J Hewitt Juling Ong Alfred G. Becking Jenny Gains Julie Bradley Eric Sandler Mark N. Gaze Bradley Pieters Henry Mandeville Raquel Dávila Fajardo Reineke Schoot Johannes H. M. Merks Peter Hammond Ludwig E. Smeele Michael Suttie 《Pediatric blood & cancer》2023,70(8):e30412
Background
The four different local therapy strategies used for head and neck rhabdomyosarcoma (HNRMS) include proton therapy (PT), photon therapy (RT), surgery with radiotherapy (Paris-method), and surgery with brachytherapy (AMORE). Local control and survival is comparable; however, the impact of these different treatments on facial deformation is still poorly understood. This study aims to quantify facial deformation and investigates the differences in facial deformation between treatment modalities.Methods
Across four European and North American institutions, HNRMS survivors treated between 1990 and 2017, more than 2 years post treatment, had a 3D photograph taken. Using dense surface modeling, we computed facial signatures for each survivor to show facial deformation relative to 35 age–sex–ethnicity-matched controls. Additionally, we computed individual facial asymmetry.Findings
A total of 173 HNRMS survivors were included, survivors showed significantly reduced facial growth (p < .001) compared to healthy controls. Partitioned by tumor site, there was reduced facial growth in survivors with nonparameningeal primaries (p = .002), and parameningeal primaries (p ≤.001), but not for orbital primaries (p = .080) All patients were significantly more asymmetric than healthy controls, independent of treatment modality (p ≤ .001). There was significantly more facial deformation in orbital patients when comparing RT to AMORE (p = .046). In survivors with a parameningeal tumor, there was significantly less facial deformation in PT when compared to RT (p = .009) and Paris-method (p = .007).Interpretation
When selecting optimal treatment, musculoskeletal facial outcomes are an expected difference between treatment options. These anticipated differences are currently based on clinicians’ bias, expertise, and experience. These data supplement clinician judgment with an objective analysis highlighting the impact of patient age and tumor site between existing treatment options. 相似文献5.
Renson Thomas Forkert Nils D. Amador Kimberly Miettunen Paivi Parsons Simon J. Dhalla Muhammed Johnson Nicole A. Luca Nadia Schmeling Heinrike Stevenson Rebeka Twilt Marinka Hamiwka Lorraine Benseler Susanne 《Pediatric rheumatology online journal》2023,21(1):1-2
To characterize the clinical features and outcomes of childhood-onset primary Sjögren’s syndrome (pSS). Patients less than 18 years old who were diagnosed with pSS by paediatric rheumatologists were included, and all patients were applied the 2002 American-European Consensus Group (ACEG) criteria, the 2016 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria for pSS, or the 1999 proposed juvenile pSS criteria. The electronic medical records of patients with pSS from 2013 to 2020 were collected and analysed. Thirty-nine patients were included. Of them, 27 (69.2%), 38 (97.4%) and 35 (89.7%) patients fulfilled the AECG criteria, ACR/EULAR criteria and proposed juvenile pSS criteria, respectively. The female:male ratio was 3.9:1. The median ages at first signs or symptoms and at diagnosis were 9.2 (4.7, 14.5) years and 10.9 (6.3, 15.0) years, respectively. The main clinical manifestations were rash or purpura (20, 51.3%), followed by fever (12, 30.8%), glandular enlargement/recurrent parotitis (10, 25.6%), and dry mouth and/or dry eyes (9, 23.1%). Twenty-eight (56.4%) patients had systemic damage, the most common of which was haematological involvement (14, 35.9%), followed by hepatic (13, 33.3%) and renal involvement (8, 20.5%). Thirty-eight (97.4%) patients underwent labial minor salivary gland biopsy, and all exhibited focal lymphocytic sialadenitis. All patients had a global ESSDAI score ≥ 1 at diagnosis, and the median total score at diagnosis was 8 (2, 31). Thirty-six (92.3%) patients were followed up for a median time of 23.6 (7.9, 79.5) months, and three patients developed systemic lupus erythematosus (SLE) at follow-up times of 13.3, 38.8 and 63.8 months. The presentation of childhood-onset pSS is atypical, and extraglandular manifestations and systemic involvement are more common than in adult-onset pSS. Labial salivary gland biopsy is vital for patients with probable pSS. Some patients may develop SLE over time. 相似文献
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8.
Rops Angelique L.; van den Hoven Mabel J.; Bakker Marinka A.; Lensen Joost F.; Wijnhoven Tessa J.; van den Heuvel Lambert P.; van Kuppevelt Toin H.; van der Vlag Johan; Berden Jo H. 《Nephrology, dialysis, transplantation》2007,22(8):2416
Nephrol Dial Transplant 2007; 22(7): 相似文献
9.
10.
Smets EM Stam MM Meulenkamp TM van Langen IM Wilde AA Wiegman A de Wert GM Tibben A 《American journal of medical genetics. Part A》2008,(6):700-707
Familial hypercholesterolemia, hypertrophic cardiomyopathy, and long QT Syndrome are genetic cardiovascular conditions which may lead to sudden cardiac death at a young age. Preventive measures include lifestyle modifications, medications, and/or cardiac devices. Hence, identification of carrier children can protect them for the potentially life threatening consequences at a young age. Yet, informing children about their genetic risk status and subjecting them to treatment may have negative consequences. This preliminary study aimed to explore (1) how the health-related quality of life of carrier children compares to the quality of life of Dutch children in general; and (2) to what extent the carrier children's quality of life and their parents' perception thereof concur. Our method involved carrier children (n = 35), aged between 8 and 18 years, and their parents (n = 37) who completed a self-report questionnaire. Children's health-related quality of life was assessed with a children and parent version of the KIDSCREEN. Dutch reference data were available from a representative national sample. Our results show no statistically significant differences in scores between carrier children and the reference group. Also, no differences were found between carrier children and their parents' ratings, with the exception of the scale "psychological well being". Parents rated their child's psychological well being significantly lower. We identified no problems with the well-being of carrier children as compared to a representative sample of peers. This may offer some initial reassurance to those who have concerns about the implications of genetically testing children for one of these cardiovascular conditions. Yet, attention to possible problems in these children remains warranted. 相似文献