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排序方式: 共有97条查询结果,搜索用时 31 毫秒
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Algros MP Collonge-Rame MA Bedgejian I Tropet Y Delattre O Kantelip B 《Annales de pathologie》2003,23(3):244-248
Extraskeletal myxoid chondrosarcoma (EMC) is a phenotypically and genotypically distinct entity with a protracted course. A documented case of an extraskeletal myxoid chondrosarcoma characterized by a t(9; 17) (q22; q11) translocation with a neuroendocrine and neural differentiation is reported. 相似文献
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Chloé Cloteau Gaud Dervilly Zied Kaabia Florian Bagilet Vivian Delcourt Benoit Loup Yann Guitton Anne-Lise Royer Fabrice Monteau Patrice Garcia Marie-Agnès Popot Bruno Le Bizec Ludovic Bailly-Chouriberry 《Drug testing and analysis》2022,14(5):864-878
In order to overcome the challenge associated with the screening of Anabolic-Androgenic Steroids abuses in animal competitions, a non-targeted liquid chromatography coupled to high resolution mass spectrometry based metabolomics approach was implemented on equine urine samples to highlight potential biomarkers associated with the administration of such compounds, using testosterone esters as model steroids. A statistical model relying on four potential biomarkers intensity could be defined to predict the status of the samples. With a routine application perspective, the monitoring of the highlighted potential biomarkers was first transferred into high-throughput liquid chromatography-selected reaction monitoring (LC-SRM). The model's performances and robustness of the approach were preserved and providing a first demonstration of metabolomics-based biomarkers integration within a targeted workflow using common benchtop MS instrumentation. In addition, with a view to the widespread implementation of such biomarker-based tools, we have transferred the method to a second laboratory with similar instrumentation. This proof of concept allows the development and application of biomarker-based strategies to meet current doping control needs. 相似文献
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Frémeaux-Bacchi V Guinnepain MT Cacoub P Dragon-Durey MA Mouthon L Blouin J Cherin P Laurent J Piette JC Fridman WH Weiss L Kazatchkine MO 《The American journal of medicine》2002,113(3):194-199
PURPOSE: Acquired angioedema type 1 is characterized by a C1 inhibitor deficiency in patients with lymphoproliferative disorders, whereas acquired angioedema type 2 is characterized by anti-C1 inhibitor antibodies, and has not been thought to be associated with lymphoproliferative disease. We studied the clinical features, complement profiles, and associated diseases in 19 new patients with diagnosed acquired angioedema type 2. SUBJECTS AND METHODS: Plasma concentrations and functional activity of complement components were measured by conventional techniques. Functional C1 inhibitor activity was assessed by a chromogenic assay. Autoantibodies to C1 inhibitor were detected using an enzyme-linked immunosorbent assay. RESULTS: The 11 men and 8 women (median age, 60 years) presented with recurrent attacks of angioedema. All patients had detectable anti-C1 inhibitor antibodies in serum. A monoclonal gammopathy was detected in 12 patients (63%) at the time of diagnosis, 11 of whom had an immunoglobulin peak of the same heavy- and light-chain isotypes as the acquired anti-C1 inhibitor antibody. Three of these 12 patients developed a malignant lymphoproliferative disease. CONCLUSION: As with type 1 disease, a large proportion of patients with acquired angioedema type 2 have a lymphoproliferative disorder. 相似文献
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Arnal MA Mosoni L Dardevet D Ribeyre MC Bayle G Prugnaud J Patureau Mirand P 《The Journal of nutrition》2002,132(5):1002-1008
Muscle loss during aging could be related to a lower sensitivity of muscle protein synthesis to feeding. To overcome this decrease without increasing protein intake, we proposed to modulate the daily protein feeding pattern. We showed that consuming 80% of dietary proteins at noon (pulse pattern) improved nitrogen balance in elderly women. The present study was undertaken in rats to determine which tissues are the targets of the pulse pattern and what mechanisms are involved. Male Sprague-Dawley 11- and 23-mo-old rats (n = 32 per age) were fed 4 isoproteic (18% protein) meals/d for 10 d. Then half of the rats at each age were switched to a 11/66/11/11% repartition of daily proteins (pulse pattern) for 21 d. On d 21, rats were injected with a flooding dose of L-(13)C-valine (50 atom% excess, 150 micromol/100 g body) and protein synthesis rates were measured in liver, small intestine and gastrocnemius muscle in either the postabsorptive or the fed state. Epitrochlearis muscle degradation rates and plasma amino acid concentrations were measured at the same times. The pulse pattern had the following effects: 1) it significantly increased liver protein synthesis response to feeding and postprandial plasma amino acid concentrations at both ages; 2) it restored a significant response to feeding of gastrocnemius muscle protein synthesis in old rats; and 3) it had no effect in small intestine or on muscle breakdown. Thus, using a pulse pattern could be useful in preventing the age-related loss of muscle by increasing feeding-induced stimulation of muscle protein synthesis. 相似文献
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Haemolytic uraemic syndrome (HUS) is a thrombotic microangiopathy (TMA) disorder characterised by the association of haemolytic
anaemia, thrombocytopenia and acute renal failure. Atypical forms (non-related to shigatoxin) may be familial or sporadic,
with frequent recurrences and most of them lead to end stage renal failure. During the last years, different groups have demonstrated
genetic predisposition of atypical HUS involving complement components factor H (FH), CD46 [or membrane co-factor protein
(MCP)] and factor I. These three proteins are involved in the regulation of the alternative pathway of the complement system.
Several series have reported mutations in the FH gene (called HF1) in between 10 and 22% of atypical HUS patients. At this time, four pedigrees corresponding to 13 cases have been reported
with an MCP mutation and four cases with a sporadic disease presented factor I mutation. Whereas FH mutations were reported
in both familial and sporadic forms of HUS, CD46 mutations were restricted to familial HUS, and factor I mutations were only
observed in cases of sporadic HUS. We speculate that the penetrance of the disease may be variable regarding the identified
susceptibility factors. Recently, the analysis of single nucleotide polymorphisms in both HF1 and MCP in three large cohorts of HUS patients identified significant association between atypical HUS and HF1 and MCP particular
alleles. All these results, together with the finding of anti-FH antibodies in some atypical HUS patients, strongly suggest
that an abnormality in the regulation of the alternative pathway participates in the patho-physiological mechanisms of atypical
HUS. The recent progress made in the determination of susceptibility factors for atypical HUS has permitted the development
of new diagnostic tests and may eventually lead to new specific treatments to block the pathological process. 相似文献
8.
Mirand PP Arnal-Bagnard MA Mosoni L Faulconnier Y Chardigny JM Chilliard Y 《The Journal of nutrition》2004,134(9):2263-2269
Dietary CLA isomers were shown to reduce adipose tissues in growing animals, mainly in mice, but their effects in adult animals remain unclear. This study was conducted to determine whether these effects depend on the isomer fed, on physical activity, or on the initial level of body fat. Male Wistar rats (4 mo old) were fed for 6 wk diets containing either no CLA, the cis-9, trans-11 CLA isomer (10 g/kg), the trans-10, cis-12 CLA isomer (10 g/kg), or both isomers (10 g/kg each). Half of the rats were assigned to exercise by treadmill running (1 h/d, 22 m/min). The initial body fat level was normal (12.7%) in a first trial, and high (18.9%) in a second trial. Chemical and anatomical body compositions were determined by chemical analysis and organ dissection. In both trials, the CLA diets, whatever the isomer, had no effect on food intake and body weight changes, on body chemical composition (fat, protein and water contents or gains), or on the body anatomical composition (weights or gains in epididymal and perirenal adipose tissues, in liver and in 4 muscles). There was no interaction between CLA treatment and physical activity. In conclusion, adult male rats do not appear to be responsive to the fat-to-lean partitioning effect of CLA described in growing rats. This was not affected by exercise or initial body fat level. 相似文献
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Pierre?Kalfon Karine?Baumstarck Philippe?Estagnasie Marie-Agnès?Geantot Audrey?Berric Georges?Simon Bernard?Floccard Thomas?Signouret Mohamed?Boucekine Mélanie?Fromentin Martine?Nyunga Achille?Sossou Marion?Venot René?Robert Arnaud?Follin Juliette?Audibert Anne?Renault Ma?té?Garrouste-Orgeas Olivier?Collange Quentin?Levrat Isabelle?Villard Didier?Thevenin Julien?Pottecher René-Gilles?Patrigeon Nathalie?Revel Coralie?Vigne Elie?Azoulay Olivier?Mimoz Pascal?Auquier 《Intensive care medicine》2017,43(12):1829-1840