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1.
Chronic hepatitis C in patients with persistently normal alanine transaminase levels. 总被引:2,自引:0,他引:2
Mitchell L Shiffman Moisés Diago Albert Tran Paul Pockros Robert Reindollar Daniele Prati Maribel Rodríguez-Torres Pilar Lardelli Steven Blotner Stefan Zeuzem 《Clinical gastroenterology and hepatology》2006,4(5):645-652
BACKGROUND & AIMS: Many patients with chronic hepatitis C virus (HCV) have persistently normal serum alanine transaminase (ALT) levels. We compared characteristics of chronic hepatitis C patients with patients with normal and elevated ALT levels using data from 3 randomized phase III trials of peginterferon alfa-2a (40 kDa). METHODS: The characteristics of 480 patients with normal ALT values (on >or=3 occasions without any increases in ALT level over a 6- to 18-month period) and 1993 patients with elevated ALT levels were compared. Sixty-eight of the 480 patients with normal ALT levels were randomized to no treatment and monitored for 72 weeks. RESULTS: More patients with normal ALT levels than patients with elevated ALT levels were women (59% vs 32%; P<.01). The serum HCV RNA titer was significantly lower in patients with normal ALT levels (P<.01 vs in patients with elevated ALT levels). Patients with normal ALT levels had significantly lower inflammation and fibrosis scores on liver biopsy examination than patients with elevated ALT levels, but almost two-thirds had portal fibrosis and 10% had bridging fibrosis. No correlation between baseline ALT activity, HCV RNA level, and liver histology was observed in patients with normal ALT levels. During the 72-week follow-up period, ALT activity elevated above the upper limit of normal in 53% of the untreated patients with normal levels of ALT. None became HCV RNA undetectable. CONCLUSIONS: Chronic hepatitis C patients with normal ALT levels should be evaluated in a similar manner as patients with elevated ALT levels because they are at risk for developing significant liver disease. The decision to treat with peginterferon alfa and ribavirin should be based on multiple factors, rather than on ALT levels alone. 相似文献
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Betzana Zambrano Fernando Noriega Gustavo H. Dayan Doris Maribel Rivera Jos Luis Arredondo Humberto Reynales Kleber Luz Carmen Deseda Matthew I. Bonaparte Edith Langevin Yukun Wu Margarita Corts Stephen Savarino Carlos A. DiazGranados 《The American journal of tropical medicine and hygiene》2021,104(1):136
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Jorian Prudhomme Céline Toty Ozge Erisoz Kasap Nil Rahola Baptiste Vergnes Carla Maia Lenea Campino Maria Antoniou Maribel Jimenez Ricardo Molina Arnaud Cannet Bulent Alten Denis Sereno Anne-Laure Bañuls 《Acta tropica》2015
The population structure of Phlebotomus ariasi, a proven vector of Leishmania infantum in the Mediterranean area, is still poorly understood. Previously, only two microsatellite loci had been developed to study the population genetics of this species. Herein we use these loci and determined fourteen novel microsatellite loci, useful for the characterization of P. ariasi populations. These loci were tested on three populations of P. ariasi, two from France and one from Portugal. In addition, the usefulness of these markers was also evaluated on seven other sandfly species. 相似文献
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Moroi Masaaki; Jung Stephanie M.; Nomura Shosaku; Sekiguchi Sadayoshi; Ordinas Antonio; Diaz-Ricart Maribel 《Blood》1997,90(11):4413-4424
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Alessandra Mangia Tivadar Bányai Giuseppe De Bartolomeo Judit Gervain François Habersetzer Jean‐Pierre Mulkay Denis Ouzan Giustino Parruti Nicola Passariello Andre‐Jean Remy Mario Rizzetto Mitchell L. Shiffman Manuela Schmitz Fernando Tatsch Maribel Rodriguez‐Torres 《Liver international》2014,34(7):e217-e228
9.
Marc Blasi Javier de la Fuente Carlo Martinoli Juan Blasi Albert Pérez-Bellmunt Tomás Domingo Maribel Miguel-Pérez 《Surgical and radiologic anatomy : SRA》2014,36(1):17-24
Purpose
The aim of this study is to correlate the ultrasound (US) appearance of the persistent double or bifid distal tendon of the biceps brachii muscle with anatomical and histological data. This will provide a new model to study the pathological distal biceps brachii tendon (DBBT).Methods
The DBBT of 20 cadaveric elbows were examined with linear array broadband US transducers (frequency band 14–6 MHz) using an anterior approach. Trypan blue dye was injected underneath the paratenon under US guidance in 16 specimens. After they were dissected, five of them were processed to obtain histological slices stained with hematoxylin–eosin and antiserum to protein S100.Results
At US, the DBBT is a tendon in which the fascicles are organized in two different hyperechoic components separated by a hyperechoic septum related to the endotenon. The endotenon is lax, flexible, and makes folding and gliding of the two portions feasible. The DBBT is surrounded by a hyperechoic paratenon adjacent to the tendon surface, which is only differentiable by US when dye is interposed between such structures.Conclusions
The connective septum of endotenon located between the two main components of the DBBT is responsible for the US image of two separate tendons and functionally enables it to work as two separate entities, thus allowing respective folding and gliding. The paratenon surrounding the lacertus fibrosus and the DBBT plays an important stabilization role, enabling them to change shape and arrangement during joint motion. It is also an important conduit for nerves and blood vessels. 相似文献10.
Virginia Leiro Fernández Maribel Botana Rial Cristina Represas Represas Ana González Piñeiro Victor del Campo Pérez Alberto Fernández-Villar 《Archivos de bronconeumología》2012
Transbronchial needle aspiration (TBNA) of pulmonary lesions without endobronchial affectation in combination with transbronchial biopsy (TBB) has been shown to increase diagnostic performance. The objective of this present study was to analyze whether the combination of TBNA with conventional TBB is a cost-effective approach. 相似文献