排序方式: 共有12条查询结果,搜索用时 10 毫秒
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Balán Iván C. Lentz Cody Giguere Rebecca Dolezal Curtis Kajura-Manyindo Clare Kutner Bryan A. Zalwango Aisha Makoni Rujeko Madlala Bernadette Makala Yvonne Khanyile Nombuso Kadyamusuma McLoddy Kachenjera Lonely Ndhlovu-Forde Zanele Tuswa-Haynes NoCamagu 《AIDS and behavior》2022,26(3):698-708
AIDS and Behavior - Evidence-based adherence counseling interventions must be delivered with fidelity to ensure that their effectiveness is retained, but little is known regarding how counselors in... 相似文献
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Kathryn Therese Mngadi Silvia Maarschalk Anneke C. Grobler Leila E. Mansoor Janet A. Frohlich Bernadette Madlala Nelisiwe Ngcobo Salim S. Abdool Karim Quarraisha Abdool Karim 《AIDS and behavior》2014,18(5):849-854
Young women in sub-Saharan Africa are disproportionately affected by HIV, making the development of women initiated and controlled methods of prevention, including microbicides, a priority. Adherence is pivotal to microbicide efficacy and partner related factors are known to impact adherence. An analysis of disclosure of gel use to sexual partners and adherence in CAPRISA 004 women was conducted to better understand this relationship. Partner disclosure was significantly associated with a modest 4.2 % increased adherence (71.0 vs. 66.8 %, p = 0.03). Most women rated the experience of disclosure as positive, despite 6.7 % of partners expressing a negative reaction.Participants who disclosed were more likely to reside with their regular partner (14.4 vs. 8.4 %; p = 0.01) and reported consistent condom use at baseline (32.9 vs. 20.9 %; p < 0.01). Partner disclosure needs to be better understood as a potential facilitator or barrier to microbicide adherence. 相似文献
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Leila Essop Mansoor Quarraisha Abdool Karim Lise Werner Bernadette Madlala Nelisiwe Ngcobo Deborah H. Cornman K. Rivet Amico Jeffrey Fisher William A. Fisher Kathleen M. MacQueen Salim S. Abdool Karim 《AIDS and behavior》2014,18(5):841-848
High adherence is important in microbicide trials, but no adherence interventions to date have demonstrated empiric improvements in microbicide adherence or effectiveness. Approximately midway during the CAPRISA 004 trial, we implemented a novel adherence intervention (Adherence Support Program—ASP), based on an Information–Motivation–Behavioral Skills model and incorporating a Motivational Interviewing approach. We assessed the impact of the ASP on adherence and tenofovir gel effectiveness using a before-and-after comparison. Of the 889 women in the trial, 774 contributed 486.1 women-years of follow-up pre-ASP and 828 contributed 845.7 women-years of follow-up post-ASP. Median adherence rose from 53.6 % pre-ASP to 66.5 % post-ASP. Detectable tenofovir levels increased from 40.6 % pre-ASP to 62.5 % post-ASP in 64 women who had paired tenofovir drug samples. Gel effectiveness improved post-ASP; HIV incidence in the tenofovir gel arm was 24 % lower pre-ASP compared to 47 % lower post-ASP. Following implementation of the ASP, microbicide adherence improved with a concomitant increase in the effectiveness of tenofovir gel. 相似文献
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Abdool Karim Q Kharsany AB Frohlich JA Werner L Mlotshwa M Madlala BT Abdool Karim SS 《AIDS and behavior》2012,16(7):1870-1876
Young women are particularly vulnerable for acquiring HIV yet they are often excluded from clinical trials testing new biomedical intervention. We assessed the HIV incidence and feasibility of enrolling a cohort of young women for potential participation in future clinical trials. Between March 2004 and May 2007, 594 HIV uninfected 14-30?year old women were enrolled into a longitudinal HIV risk reduction study in KwaZulu-Natal, South Africa. The overall HIV prevalence at screening in young girls below the age of 18?years was 27.6?% compared to 52.0?% in the women above 18?years, p?0.001. HIV incidence was 4.7 [95?% Confidence interval (CI) 1.5-10.9) and 6.9 (95?% CI 4.8-9.6)/100 women years (wy), p?=?0.42 and pregnancy rates were 23.7 (95?% CI 14.9-35.9) and 16.4 (95?% CI 12.9-20.6)/100?wy, p?=?0.29, in the women below and above 18?years respectively. Retention was similar in both groups (71.0 vs. 71.5?%, p?=?0.90). This study demonstrates that the inclusion of young girls between the ages of 14 and 17?years in longitudinal studies is feasible and their inclusion in clinical trials would maintain scientific integrity and power of the study. 相似文献
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Samukelisiwe S. Madlala Jillian Hill Ernesta Kunneke Andre P. Kengne Nasheeta Peer Mieke Faber 《Nutrients》2022,14(15)
In South Africa, the nutrition transition has led to unhealthy diets lacking variety, contributing to the rise in overweight, obesity and diet-related noncommunicable diseases. Using baseline screening data of the South African Diabetes Prevention Programme (SA-DPP) study, this study aims to determine the relationship of dietary diversity (DD) with nutritional status, cardiometabolic risk factors and food choices of adults at risk of type 2 diabetes in resource-poor communities around Cape Town. Data of 693 adults, 25–65 years old were analysed. This included socio-demographic information, anthropometric measurements, biochemical assessments, food groups consumed the previous day and consumption frequency of certain foods to reflect food choices. The Minimum Dietary Diversity for Women (MDD-W) indicator was calculated; 70.4% of participants had low DD (<5 food groups). Low DD was associated with elevated serum triglycerides [AOR: 1.49, 95% CI (1.03, 2.15) p = 0.036]. The DD score was positively correlated (although weak) with the unhealthy food score (r = 0.191, p = 0.050) and sugary food score (r = 0.139, p < 0.01). Study participants at risk of diabetes consumed a diet low in DD; however, DD was not associated with nutritional status or cardiometabolic risk factors except for serum triglycerides. 相似文献