排序方式: 共有11条查询结果,搜索用时 15 毫秒
1.
MASASHI YOSHIDA GO WAKABAYASHI HIDEKI ISHIKAWA YOSHIHIDE OTANI MOTOHIDE SHIMAZU TETSURO KUBOTA KOICHIRO KUMAI IWAO KUROSE SOICHIRO MIURA HIROMASA ISHII MASAKI KITAJIMA 《Journal of gastroenterology and hepatology》1998,13(1):104-108
The effects of camostat mesilate, a synthetic serine protease inhibitor on gastric microcirculation and active oxygen species generated by leucocytes from the gastric and jugular veins in the early period after thermal injury were assessed. Male Wistar rats were anaesthetized and a 30% full skin-thickness dorsal burn was inflicted. Camostat mesilate (100 mg/kg) was dissolved in distilled water and administered orally to rats 40 min before thermal injury (the camostat group). The control animals (the vehicle group) were administered distilled water orally. Rolling leucocytes as well as Monastral blue B deposits in venules were observed using in vivo microscopy. Active oxygen species were measured by chemiluminescence. Camostat mesilate decreased the total length of gastric erosion, venular deposits of Monastral blue B, and rolling of leucocytes in venules, and relatively increased luminol-dependent chemiluminescence activity generated by zymosan-stimulated leucocytes 15 min after thermal injury. These results suggest that serine proteases are involved in the formation of gastric erosions and gastric microcirculatory disturbance in the early period after thermal injury. 相似文献
2.
Akiomi INOUE Norito KAWAKAMI Teruichi SHIMOMITSU Akizumi TSUTSUMI Takashi HARATANI Toru YOSHIKAWA Akihito SHIMAZU Yuko ODAGIRI 《Industrial health》2014,52(6):535-540
This study was aimed to investigate the test-retest reliability and validity of a short
version of the New Brief Job Stress Questionnaire (New BJSQ) whose scales have one item
selected from a standard version. Based on the results from an anonymous web-based
questionnaire of occupational health staffs and personnel/labor staffs, we selected
higher-priority scales from the standard version. After selecting one item with highest
item-total correlation coefficient from each scale, a 23-item questionnaire was developed.
A nationally representative survey was administered to Japanese employees
(n=1,633) to examine test-retest reliability and
validity. Most scales (or items) showed modest but adequate levels of test-retest
reliability (r>0.50). Furthermore, job demands and job
resources scales (or items) were associated with mental and physical stress reactions
while job resources scales (or items) were also associated with positive outcomes. These
findings provided a piece of evidence that the short version of the New BJSQ is reliable
and valid. 相似文献
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Naoki IKEMI Junji IMADA Takeshi GOTO Hiroshi SHIMAZU Mineo YASUDA 《Congenital anomalies》1993,33(4):363-377
ABSTRACT This study was designed to determine the effects of food restriction and fasting on fetal development during major organogenesis in Sprague-Dawley rats. The maternal body weight gain markedly decreased during the 60%- and 90%-restricted feeding and fasting periods with a concomitant decrease in the plasma glucose levels. The number of resorptions slightly increased in the 90%-restricted feeding and fasting groups with lower fetal viability. The mean fetal body weight of the restricted feeding and fasting groups and the mean placental weight of male fetuses of the 60%-restricted feeding group were significantly lower than those of the control groups. Ossification of the metacarpi and metatarsi was slightly but significantly retarded by 60%-restricted feeding. The incidence of cardiovascular malformations (mainly ventricular septal defect and abnormal origin of the right subclavian artery) and visceral variations apparently increased in the restricted feeding and fasting groups. Abnormal fetuses tended to be lighter than normal fetuses. In conclusion, maternal food restriction and fasting during major organogenesis caused the fetal growth retardation with slightly delayed ossification and a high incidence of cardiovascular abnormalities in rats. This possibility must be taken into consideration when teratology data with a reduction in maternal food consumption are evaluated. 相似文献
6.
MASASHI YOSHIDA DAI FUKUMURA GO WAKABAYASHI YOSHIHIDE OTANI ATSUSHI OSHIMA MOTOHIDE SHIMAZU TETSURO KUBOTA KOICHIRO KUMAI IWAO KUROSE SOICHIRO MIURA MASAKI KITAJIMA 《Journal of gastroenterology and hepatology》1995,10(4):365-370
In order to investigate the pathogenesis of acute gastric mucosal lesion after thermal injury, microcirculatory disturbance was assessed and observation of the behaviour of leucocytes was performed. Gastric blood flow decreased at 15 min post-thermal injury, and partially improved at 2 h; however, it decreased again at 5 h post-thermal injury. Mucosal microcirculatory disturbance was observed by using vascular labelling with monastral blue B. Deposits of monastral blue B were observed centring mainly on collecting venules but were also observed in the capillaries. Submucosal microcirculatory disturbance was observed through an intravital microscope. The irregularity of the wall and segmental constriction in the venules and presence of an arteriovenous shunting channel was observed in the submucosal layer at 5 h post-thermal injury. The percentage of rolling or sticking leucocytes that passed the confluence of a prevenule and a venule were significantly increased at 5 h after thermal injury. The present study revealed depression of gastric blood flow, mucosal and submucosal microcirculatory disturbance, and a significant increase of rolling and sticking leucocytes in the peripheral part of venules after thermal injury. Leucocyte-endothelial interactions may occur under such conditions and this interaction may play an important role in inducing the microcirculatory disturbance that results in an acute gastric mucosal lesion after thermal injury. The present study also demonstrated the possibility of intravital study of gastric submucosal arteriovenous shunting channels. 相似文献
7.
Akihito SHIMAZU Norito KAWAKAMI Kazumi KUBOTA Akiomi INOUE Sumiko KURIOKA Koichi MIYAKI Masaya TAKAHASHI Akizumi TSUTSUMI 《Industrial health》2013,51(5):472-481
Recent epidemiologic research has shown that people with higher socioeconomic status
(SES) (e.g., educational attainment) have better psychological health than those with
lower SES. However, the psychosocial mechanisms of underlying this relationship remain
unclear. To fill this gap, the current study examines the mediating effects of job demands
and job resources in the relationship between educational attainment and psychological
distress. The hypothesized model was tested using large data sets from two different
studies: a cross-sectional study of 9,652 Japanese employees from 12 workplaces (Study 1),
and a longitudinal study of 1,957 Japanese employees (Study 2). Structural equation
modeling revealed that (1) educational attainment was positively related to psychological
distress through job demands, (2) educational attainment was negatively related to
psychological distress through job resources, and (3) educational attainment was not
directly related to psychological distress. These results suggest that educational
attainment has an indirect effect, rather than a direct one, on psychological distress
among workers; educational attainment had both a positive and a negative relationship to
psychological distress through job demands and job resources, respectively. 相似文献
8.
Y. YUTANI T. KONO M. ISHII M. CHANOKI Y. CHANOKI K. ASADA A. SHIMAZU T. HAMADA 《Clinical and experimental dermatology》1991,16(1):22-24
Articular tissue was obtained at surgery for a femoral neck fracture in a patient with psoriasis without arthritis. The proteoglycan of the cartilage of the sample was analysed biochemically. Normal cartilage is known to produce two types of proteoglycan monomers (fast- and slow-sedimenting groups), which are distinguishable by density-gradient ultracentrifugation. In the psoriatic cartilage analysed in the present study, it was shown that the former group was absent and only the latter group remained. 相似文献
9.
This study evaluated the effectiveness of a computer-based stress management training
(SMT) program in improving employees’ psychological well-being and work performance. A
total of 12 work units (N=263) were randomly assigned to
either an intervention group (8 work units, n=142) or to a
wait-list control group (4 work units, n=121). All
participants were requested to answer online questionnaires assessing psychological
well-being as a primary outcome, and coping style, social support, and knowledge about
stress management as secondary outcomes at baseline (T0), immediately after the
intervention (T1), and 2 months after the intervention (T2). The group × time interaction
was tested using a mixed-model repeated measures ANOVA. Results showed a group × time
interaction for “knowledge about stress management” in the entire sample. Among
participants who had more than 3 d of training, a significant group × time interaction was
observed for “problem-solving” and “avoidance and suppression” as well as “knowledge about
stress management.” Our computer-based stress management program was effective for
improving knowledge about stress management. It was also effective for improving coping
skills in instances where participants had enough time (at least 3 d) to complete all
sessions. 相似文献
10.
Akiomi INOUE Norito KAWAKAMI Teruichi SHIMOMITSU Akizumi TSUTSUMI Takashi HARATANI Toru YOSHIKAWA Akihito SHIMAZU Yuko ODAGIRI 《Industrial health》2014,52(3):175-189
This study aimed to investigate the reliability and construct validity of a new version
of the Brief Job Stress Questionnaire (New BJSQ), which measures an extended set of
psychosocial factors at work by adding new scales/items to the current version of the
BJSQ. Additional scales/items were extensively collected from theoretical job stress
models and similar questionnaires in several countries. Scales/items were field-tested and
refined through a pilot internet survey. Finally, an 84-item questionnaire (141 items in
total when combined with the current BJSQ) was developed. A nationally representative
survey was administered to employees in Japan (n=1,633) to
examine the reliability and construct validity. Most scales showed acceptable levels of
internal consistency and test-retest reliability. Principal component analyses showed that
the first factor explained 50% or greater proportion of the variance in most scales. A
scale factor analysis and a correlation analysis showed that these scales fit the
theoretical expectations. These findings provided a piece of evidence that the New BJSQ
scales are reliable and valid. Although more detailed content and construct validity
should be examined in future study, the New BJSQ is a useful instrument to evaluate
psychosocial work environment and positive mental health outcomes in the current
workplace. 相似文献