全文获取类型
收费全文 | 578篇 |
免费 | 25篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 59篇 |
妇产科学 | 2篇 |
基础医学 | 41篇 |
口腔科学 | 7篇 |
临床医学 | 38篇 |
内科学 | 138篇 |
皮肤病学 | 19篇 |
神经病学 | 47篇 |
特种医学 | 2篇 |
外科学 | 104篇 |
综合类 | 5篇 |
预防医学 | 12篇 |
眼科学 | 9篇 |
药学 | 63篇 |
中国医学 | 3篇 |
肿瘤学 | 47篇 |
出版年
2021年 | 6篇 |
2017年 | 3篇 |
2016年 | 10篇 |
2015年 | 12篇 |
2014年 | 6篇 |
2013年 | 11篇 |
2012年 | 8篇 |
2011年 | 3篇 |
2010年 | 16篇 |
2009年 | 13篇 |
2008年 | 2篇 |
2007年 | 11篇 |
2006年 | 40篇 |
2005年 | 12篇 |
2004年 | 14篇 |
2003年 | 19篇 |
2002年 | 14篇 |
2001年 | 5篇 |
2000年 | 6篇 |
1999年 | 13篇 |
1998年 | 35篇 |
1997年 | 41篇 |
1996年 | 26篇 |
1995年 | 33篇 |
1994年 | 17篇 |
1993年 | 16篇 |
1992年 | 11篇 |
1991年 | 10篇 |
1990年 | 8篇 |
1989年 | 4篇 |
1988年 | 7篇 |
1987年 | 9篇 |
1986年 | 9篇 |
1985年 | 8篇 |
1984年 | 6篇 |
1983年 | 4篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 4篇 |
1975年 | 3篇 |
1964年 | 3篇 |
1959年 | 6篇 |
1958年 | 16篇 |
1957年 | 21篇 |
1956年 | 12篇 |
1955年 | 21篇 |
1954年 | 23篇 |
排序方式: 共有603条查询结果,搜索用时 125 毫秒
1.
YOSHINORI MORITA NOBUO AOYAMA DAISUKE SHIRASAKA MASATERU FUKUDA MASATO KASUGA 《Digestive endoscopy》2003,15(Z1):S12-S14
In Kobe University Hospital, a new method for endoscopic mucosal resection (EMR) using insulated‐tip electrosurgical knife (IT‐EMR) for early gastric cancer (EGC) was introduced from November 2001. To achieve an effective and safe IT‐EMR procedure, we use a high‐frequency surgical unit for cutting and coagulation (ERBOTOM ICC 200) with automatically controlled cutting mode (ENDOCUT). In this study, we show not only our results of IT‐EMR for EGC in comparison with those of the conventional strip biopsy method, but also the optimal conditions for the apparatus of a high‐frequency surgical unit to prevent complications such as bleeding and perforation. 相似文献
2.
Reliability and validity of the Japanese version of the Yale-Brown Obsessive-Compulsive Scale 总被引:3,自引:2,他引:1
TERUO NAKAJIMA MD MICHIHIKO NAKAMURA MD CHIAKI TAGA MD SAKAE YAMAGAMI MD NOBUO KIRIIKE MD TOSHIHIKO NAGATA MD MASAMI SAITOH MD TOSHIHIKO KINOSHITA MD YOSHIYASU OKAJIMA MD MASANORI HANADA MD HIROYASU TAZOE MD KENYA YAMAGUCHI MD 《Psychiatry and clinical neurosciences》1995,49(2):121-126
Abstract The reliability and validity of the Japanese version of the Yale-Brown Obsessive-Compulsive Scale (JY-BOCS) were determined by 20 raters for 12 Japanese patients with obsessive compulsive disorder at four institutions. Interrater reliability for the total JY-BOCS score was excellent, and the intraclass correlation coefficient was high (ICC = 0.960). Internal consistency was also excellent (Cronbach's α= 0.889). Concurrent and discriminant validity of the JY-BOCS was examined by comparing the scores on the JY-BOCS with those on the Maudsley Obsessional Compulsive Inventory (MOCI) and scales for depression and anxiety. A slight correlation was found between scores on the JY-BOCS and MOCI, but no significant correlations were found between scores on the JY-BOCS and those on scales for depression or anxiety. 相似文献
3.
4.
N. SHINTANI T. NAKAJIMA M. SUGIURA K. MURAKAMI N. NAKAMURA Y. KAGITANI & T. MAYUMI 《Scandinavian journal of immunology》1997,46(6):581-586
The authors have previously reported that homologous immunoglobulin (Ig)G reduces the occurrence of dextran sulfate sodium (DSS)-induced colitis, mainly by suppressing recruitment of immunocompetent cells into colitis lesions. However, the mechanisms of cell recruitment and of its suppression by IgG remain unclear. In addressing these questions, this study focused on the activation of T cells in the presence of macrophages. The authors found that [3 H]-thymidine uptake of T cells from DSS-induced colitis mice, but not from normal mice, was significantly enhanced when cultured with DSS-pulsed macrophages. From the profile of cytokine production, it was suggested that T helper 1 (Th1)-type cells become predominant during stimulation. Addition of homologous IgG significantly suppressed T cell proliferation in a dose-dependent manner, while no suppressive effect was observed with heterologous IgG. Mouse IgG F(ab')2 , but not Fc, fragments partially mimicked the suppressive effect of whole IgG. These findings provide evidence that Th1-type cells may play an important role in the development of DSS-induced colitis and that homologous IgG exerts its protective action at least in part through the F(ab')2 portion. 相似文献
5.
MASATO FUKUDA MD AKINOBU HATA MD SHIN-ICHI NIWA MD KEN-ICHI HIRAMATSU MD MASAFUMI YOKOKOJI MD SEIKI HAYASHIDA AM KENJI ITOH DENG KAZUYUKI NAKAGOME MD AKIRA IWANAMI MD 《Psychiatry and clinical neurosciences》1996,50(2):85-88
Abstract A female patient exhibiting functional hearing loss in her left ear demonstrated reduced amplitude of P3 component in event-related potentials (ERP) to left monaural stimulation, with preserved N1 and N2 components to stimulation of either ear. This result suggested that stimuli in the affected ear were conducted successfully up to the auditory cortex but that further processing in higher brain regions was 'repressed'. Event-related potential examination for such hysterical disorders could be useful in clarifying their brain mechanism and offer a useful diagnostic clue to its nature. 相似文献
6.
Different effects of halothane, isoflurane and sevoflurane on sarcoplasmic reticulum of vascular smooth muscle in dog mesenteric artery 总被引:1,自引:0,他引:1
M. YAMAMOTO Y. HATANO M. KAKUYAMA K. NAKAMURA T. TACHIBANA H. MAEDA K. MORI 《Acta anaesthesiologica Scandinavica》1997,41(3):376-380
Background: The direct effect of halothane on vascular smooth muscle is mediated in part via its effects on the sarcoplasmic reticulum (SR). Little information is available concerning the effects of other volatile anesthetics including isoflurane and sevoflurane, whose vascular effects differ from those of halothane. The aim of the present study was to compare the effects of halothane, isoflurane and sevoflurane on the SR by testing the contraction induced by caffeine in vascular smooth muscle. Methods: Rings without endothelium from isolated canine mesenteric artery were mounted in physiological saline solution (PSS) for isometric tension recording. After complete depletion of Ca2+ from the SR by adding 35 mM caffeine, the rings were exposed to normal Ca2+ containing PSS (Ca2+ loading), to Ca2+-free PSS for 10 min, and then to 15 mM caffeine to induce contraction. Anesthetics were administered during Ca2+ loading, the Ca2+-free phase and simultaneously with caffeine administration. Results: Halothane (0.5-2%) attenuated the caffeine-induced contraction of canine mesenteric artery when administered during Ca2+ loading in the SR (P<0.001), whereas isoflurane and sevoflurane (1–4%) failed to affect the contraction. When given simultaneously with caffeine, halothane (1–2%) potentiated the caffeine-induced contraction (P<0.05), but isoflurane and sevoflurane had no effect. When given before caffeine administration, halothane (0.5-2%), isoflurane (24%) and sevoflurane (4%) all potentiated the caffeine-induced contraction (P<0.05). Conclusion: It has been shown that halothane not only potentiates caffeine- induced Ca2+ release from the SR, but also induces contraction by releasing Ca2+ from the SR. We conclude that halothane decreases Ca2+ accumulation in the SR while exerting facilitative and additive effects on caffeine-induced Ca2+ release from the SR when applied before caffeine administration and simultaneously with caffeine, respectively, whereas isoflurane and sevoflurane lack both the ability to decrease Ca2+ accumulation and an additive effect on caffeine-induced Ca2+ release from the SR, but are able to facilitate Ca2+ release by caffeine. 相似文献
7.
DIRECT VASOCONSTRICTOR AND VASODILATOR EFFECTS OF PROPOFOL IN ISOLATED DOG ARTERIES 总被引:10,自引:0,他引:10
NAKAMURA K.; HATANO Y.; HIRAKATA H.; NISHIWADA M.; TODA H.; MORI K. 《British journal of anaesthesia》1992,68(2):193-197
We have measured the direct effects of propofol 107-104mol litre1 on isolated canine cerebral, coronary, mesenteric,femoral and renal arteries. In arterial strips precontractedsubmaximally with potassium chloride or prostaglandin F2 相似文献
8.
9.
10.
TAKASHI OKI M.D. NOBUO FUKUDA M.D. TOMOTSUGU TABATA M.D. ARATA IUCHI M.D. MASATO TANIMOTO M.D. KAZUYO MANABE M.D. YOSHIMI KAGEJI M.D. MIWA SASAKI M.D. SUSUMU ITO M.D. 《Echocardiography (Mount Kisco, N.Y.)》1995,12(4):351-358
Transesophageal echocardiography was conducted to determine the systolic pattern of the anterior mitral leaflet in patients with flat chest, and to differentiate it from that associated with mitral valve prolapse. The fronto-sagittal index (an index of chest flattening) was determined in 50 subjects using chest radiographs, and was used to classify them into a flat chest group (index < 0.38, n = 28) and a normal chest group (index ≥ 0.38, n = 22). We then used transesophageal echocardiography to examine the anterior leaflet in these subjects. A significant positive correlation was observed between the fronto-sagittal index and the short-to long-axis diameter ratio of the left ventricle in all patients. These parameters, and the left atrial dimension were lower in the flat than the normal chest group. The clear zone area of the anterior leaflet during mid-to late-systole was significantly larger in the flat chest group. However, no intergroup differences existed in the rough zone area of the anterior leaflet or in the middle scallop area of the posterior leaflet. Mitral regurgitation was observed in 20 and 12 subjects in the flat and normal chest groups, respectively. The maximum mitral regurgitant area did not differ between the two groups. The clear zone area of the anterior leaflet increased significantly following inhalation of amyl nitrite in 22 subjects of both groups, but the other areas did not increase. The mitral regurgitant area decreased or disappeared after amyl nitrite at a similar rate in each group. Thus, the decrease in the antero-posterior dimension of the thorax in subjects with flat chest affects the systolic pattern of the clear zone of the anterior leaflet more than that of the rough zone of the anterior leaflet or the posterior leaflet. This systolic pattern in such patients differs from that associated with mitral valve prolapse. 相似文献