全文获取类型
收费全文 | 95篇 |
免费 | 2篇 |
专业分类
儿科学 | 16篇 |
基础医学 | 5篇 |
临床医学 | 5篇 |
内科学 | 24篇 |
神经病学 | 5篇 |
外科学 | 11篇 |
预防医学 | 3篇 |
药学 | 19篇 |
肿瘤学 | 9篇 |
出版年
2016年 | 1篇 |
2015年 | 1篇 |
2013年 | 1篇 |
2009年 | 2篇 |
2007年 | 4篇 |
2006年 | 7篇 |
2004年 | 2篇 |
2003年 | 2篇 |
2002年 | 3篇 |
2001年 | 1篇 |
1999年 | 3篇 |
1998年 | 5篇 |
1997年 | 15篇 |
1996年 | 7篇 |
1995年 | 9篇 |
1994年 | 3篇 |
1993年 | 4篇 |
1991年 | 1篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1986年 | 3篇 |
1985年 | 2篇 |
1984年 | 5篇 |
1983年 | 2篇 |
1982年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1978年 | 2篇 |
1975年 | 2篇 |
1974年 | 1篇 |
1957年 | 2篇 |
排序方式: 共有97条查询结果,搜索用时 15 毫秒
1.
Incidence and growth pattern of simple cysts of the kidney in patients with asymptomatic microscopic hematuria 总被引:1,自引:0,他引:1
KEN MARUMO YUTAKA HORIGUCHI KEN NAKAGAWA MOTOTSUGU OYA TAKASHI OHIGASHI HIROTAKA ASAKURA JUN NAKASHIMA MASARU MURAI 《International journal of urology》2003,10(2):63-67
BACKGROUND: We examined the incidence and natural history of simple renal cysts found by ultrasonography (US) in patients referred for asymptomatic microscopic hematuria. METHODS: Among the 906 patients aged 18-78 years, 743 patients who had undergone US were included in the present study. The natural history of simple renal cysts was investigated in 55 patients who underwent periodical US examinations for more than 3 years. RESULTS: The incidence of simple renal cysts was 4.3% for ages 29 years or younger, 15.3% for ages 30-39, 21.8% for ages 40-49, 23.3% for ages 50-59 and 32.6% for ages 60 years or older; thus the incidence increased in older age groups (P = 0.0005 for men, P = 0.0020 for women). Men tended to have a higher incidence than women. The degree of hematuria did not influence the incidence of renal cysts (P = 0.9044). The annual growth rate of the mean maximum diameter was 4.2% during a 3-year follow-up period in 55 patients and 5.1% during a 6-year follow-up in 31 patients. CONCLUSION: Since the diameter of a renal cyst may increase by 5% annually, the diameter of the cyst may increase by 1.6 times in 10 years. The scheduling of follow-up examinations depends on the size at the time of disclosure, the effects on calyceal systems, or the suspicion of a concurrent malignant disease. However, the most simple renal cysts may be followed-up at an interval of more than 10 years, once a diagnosis has been established. 相似文献
2.
Cytotoxin and urease activities of Helicobacter pylori isolates from Japanese patients with atrophic gastritis or duodenal ulcer 总被引:1,自引:0,他引:1
HAJIME MURAKITA MASAMICHI HIRAI SHIGEJI ITO TAKESHI AZUMA TAKUJI KATO YOSHIHIRO KOHLI MASARU KURIYAMA 《Journal of gastroenterology and hepatology》1996,11(9):819-824
The vacuolating cytotoxin and urease secreted by Helicobacter pylori are thought to be virulent factors. Because vacuolation is potentiated by the presence of ammonium ion, which is produced by urease in vitro, it is of interest to examine whether cytotoxin and urease work reciprocally in the development of atrophic gastritis or duodenal ulcer. In the present study, patients (all H. pyloripositive) were divided into four groups: mild atrophic gastritis (group 1; nine patients), severe atrophic gastritis (group 2; 36 patients), duodenal ulcer with mild atrophic gastritis (group 3; 19 patients) and duodenal ulcer with severe atrophic gastritis (group 4; 12 patients). Cytotoxin production and urease activity of H. pylori isolated from these patients were analysed. Cytotoxin production was observed in four of nine (44.4%), 28 of 36 (77.8%), 11 of 19 (57.9%) and eight of 12 (66.7%) isolates from groups 1, 2, 3 and 4, respectively. Cytotoxin-producing H. pylori isolates were found significantly more in patients with severe atrophy than in patients with mild atrophy (P= 0.048). The mean of relative activity of cytotoxin in H. pylori isolate was 1. 6. ± 2. 3, 7. 9. ± 7. 4, 5. 8. ± 6. 0 and 9. 0 ± 9. 1 in groups 1, 2, 3 and 4, respectively. Helicobacter pylori isolates from severe atrophy or duodenal ulcer patients in groups 2 or 4 possessed significantly higher activity than those from non-ulcer patients in group 1 (P= 0.017 and 0.030, respectively). The mean of urease activity was 8. 6 ± 4. 6, 10. 0 ± 5. 9, 10. 0 ± 8. 5 and 11. 2 ± 7. 7 IU/mg in groups 1, 2, 3 and 4, respectively. These differences indicated no statistical significance. In each H. pylori isolate, the production of cytotoxin and urease were independent, which indicated that there was no reciprocal effect between them in vivo. Thus, cytotoxin-producing H. pylori isolates were more prevalent in patients with severe atrophic gastritis and the cytotoxin activities of H. pylori isolates from the patients with severe atrophic gastritis or duodenal ulcer were much higher than those from the patients with mild atrophic gastritis, which suggested that vacuolating cytotoxin may be a disease-inducing factor. 相似文献
3.
Changes in Cell Characteristics Due to Culture Conditions in Cell Lines From Human Small Cell Lung Cancer 总被引:8,自引:0,他引:8
TERASAKI TAKEO; SHISMOSATO YUKIO; NAKAJIMA TAKASHI; TSUMURAYA MASARU; MORINAGA SHOJIROH; HIROHASHI SETSUO; YAMAGUCHI KEN; KATO KANEFUSA; ICHINOSR HIROSHI; NAGATSU TOSHIHARU 《Japanese journal of clinical oncology》1986,16(3):203-212
Eight cultured cell lines were established from human smallcell lung cancers. Every cell line showed the morphologicaland biochemical characteristics of small cell cancer. Changesin cell characteristics were observed in many of these celllines when culture conditions were changed: "oat cell type"changed to "intermediate cell type" and vice versa when serum-freemedium was changed to serum-supplemented medium; a deficiencyof vitamin A in the medium caused a change to squamous cellsand vice versa; and a tumor promoter (teleocidin B) enhancedthe adherence of these cells to the surface of plastic culturedishes. These findings provide evidence that many small celllung cancer cell lines can change their morphology with changesin the environment of the cells. 相似文献
4.
5.
6.
TAKASHI NAKANO EIICHI AZUMA MASARU IDO MASAHIRO ITOH MINORU SAKURAI SHIGERU SUGA HIROSHI KAWAGUCHI 《Pediatrics international》1993,35(4):354-357
Recent research has suggested that an association exists between moyamoya disease and fibromuscular dysplasia which involves systemic vessels, including renal arteries. We report a 3 year old girl with moyamoya disease associated with bilateral renal artery stenosis. This case may support the common etiology of these two clinical conditions. To our knowledge this is the youngest case of moyamoya disease associated with bilateral renal artery stenosis. 相似文献
7.
KATSUYA YAMAMOTO MASARU TAKAYANAGI YASUSHI YOSHIHARA YUJI MURATA SEIICHI KATO MASATOSHI OTAKE HIROSHI NAKAGAWA 《Pediatrics international》1996,38(1):46-51
An 8 year old girl with acute disseminated encephalomyelitis (ADEM) is described. Elevated serum antibody titers suggested recent Mycoplasma pneumoniae infection. T2-weighted image of magnetic resonance imaging (MRI) disclosed multiple lesions of high signal intensity in bilateral basal ganglia and thalami as well as in the white matter. Postcontrast T1-weighted image revealed an enhanced lesion in the deep white matter. She showed rapid clinical improvement in response to corticosteroid therapy. The lesions had disappeared completely on MRI performed 10 weeks after the onset. ADEM is believed to be a demyelinating disorder of probable autoimmune etiology. MRI findings in this case may support the hypothesis that the primary pathological event is vascular injury and demyelination occurs only as a secondary phenomenon. 相似文献
8.
Effects of glycyrrhizin on immune-mediated cytotoxicity 总被引:10,自引:0,他引:10
MASAHIDE YOSHIKAWA YUJI MATSUI HIROSHI KAWAMOTO NORIE UMEMOTO KAZUMI OKU MASAKI KOIZUMI JUNICHI YAMAO SHIGEKI KURIYAMA HIROSHI NAKANO NOBUMICHI HOZUMI SHIGEAKI ISHIZAKA HIROSHI FUKUI 《Journal of gastroenterology and hepatology》1997,12(3):243-248
Intravenous administration of glycyrrhizin is known to decrease elevated plasma transaminase levels in patients with chronic viral hepatitis, in which immune-mediated cytotoxicity by cytotoxic T lymphocytes and tumour necrosis factor (TNF)-α is considered to play an important pathogenic role. However, the immunological interpretation of the transaminase-lowering action of glycyrrhizin is not known. Studies were performed to elucidate this action immunologically by assessing the effects of glycyrrhizin on immune-mediated cytotoxicity using an antigen-specific murine CD4+ T hybridoma line, which exhibits cytotoxicity against antigen-presenting cells after stimulation with specific antigen, and a murine TNF-α-sensitive fibroblast line. Glycyrrhizin inhibited the cytotoxic activity of the T cells against antigen-presenting cells and also suppressed TNF-α-induced cytotoxicity in the TNF-α-sensitive cell line in vitro. These results suggest that the decrease of elevated transaminase levels by glycyrrhizin in patients with chronic viral hepatitis is mediated in part by inhibition of immune-mediated cytotoxicity against hepatocytes. 相似文献
9.
ISHIDA TSUNEHIRO; KAWAI TADAKAZU; IZUO MASARU 《Japanese journal of clinical oncology》1979,9(2):291-298
A rare case of hamartomatous adiposity of the thyroid occurringin a 4-year-old Japanese boy was studied by light and electronmicroscopy. This tumor-like disorder was composed of predominantlyadipose tissue and fibrous connective tissue with muscle fibersbut only a small amount of thyroid follicles at the periphery.The ultrastructural appearance showed corresponding featuresof mature fat cells, fibroblasts and other mesenhymal cellsin various grades of differentiation, and especially of striatedmuscle cells with myofilaments having electron-dense Z-lines.The findings suggest that this tumor is a hamartomatous or heterotopicdisorder caused by histogenetic malformation during embryonaldevelopment rather than a true neoplasm. 相似文献
10.
MASARU SOGAMI SEIICHI ERA SHUNJI NAGAOKA KAZUO KUWATA KIMIHIRO KIDA KIYOSHI MIURA HIROSHI INOUYE EIJI SUZUKI SHIGEO HAYANO SHIGEKI SAWADA 《Chemical biology & drug design》1985,25(4):398-402
Human mercaptalbumin (HMA) and nonmercaptalbumin (HNA) could be separated by high-performance liquid chromatography (HPLC) at neutral pH. Using HPLC, the present authors found the nonmercapt-mercapt conversion (HNA ← HMA) during hemodialysis and the mercapt-nonmercapt conversion (HMA ← HNA) after hemodialysis in chronic renal failure, indicating HMA as the covalent carrier protein for sulfur-containing amino acids. 相似文献