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排序方式: 共有311条查询结果,搜索用时 15 毫秒
1.
Rubens Souza de OLIVEIRA Lanna Jamile Corrêa da COSTA Fernanda Atanaena Gon?alves de ANDRADE Wilson UIEDA Luzia Fátima Alves MARTORELLI Ana Paula de Arruda Geraldes KATAOKA Elizabeth Salbé Travassos da ROSA Pedro Fernando da Costa VASCONCELOS Armando de Souza PEREIRA Ant?nio Ismael Barros do CARMO Marcus Emanuel Barroncas FERNANDES 《Revista do Instituto de Medicina Tropical de S?o Paulo》2015,57(6):497-503
The outbreaks of rabies in humans transmitted by Desmodus rotundus in 2004 and 2005,
in the northeast of the Brazilian State of Para, eastern Amazon basin, made this a
priority area for studies on this zoonosis. Given this, the present study provides
data on this phenomenon in an urban context, in order to assess the possible
circulation of the classic rabies virus (RABV) among bat species in Capanema, a town
in the Amazon basin. Bats were collected, in 2011, with mist nets during the wet and
dry seasons. Samples of brain tissue and blood were collected for virological and
serological survey, respectively. None of the 153 brain tissue samples analyzed
tested positive for RABV infection, but 50.34% (95% CI: 45.67-55.01%) of the serum
samples analyzed were seropositive. Artibeus planirostris was the most common
species, with a high percentage of seropositive individuals (52.46%, 95% CI: 52.31
52.60%). Statistically, equal proportions of seropositive results were obtained in
the rainy and dry seasons (c2 = 0.057, d.f. = 1, p = 0.88). Significantly
higher proportions of males (55.96%, 95% CI: 48.96-62.96%) and adults (52.37%, 95%
CI: 47.35-57.39%) were seropositive. While none of the brain tissue samples tested
positive for infection, the high proportion of seropositive specimens indicates that
RABV may be widespread in this urban area. 相似文献
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Summary: A survey of the medical records and renal biopsy reports of 41 patients with a diagnosis of membranous glomerulonephritis seen at the University Hospital, Faculty of Medicine of Ribeirão Preto, University of São Paulo was undertaken between 1961 and April 1992. Twenty-three of these patients were found to have idiopathic membranous glomerulonephritis (IMG) and 22 of them were treated with corticosteroids and/or immunosuppressants. Data for these 22 patients showed that the age at clinical presentation was 36.3± 17.5 years, white skin colour predominated (14 patients), and 15 were males; nephrotic syndrome was the clinical presentation in 20 patients and proteinuria was accidentally discovered in two patients. On the first hospital visit 11 patients presented proteinuria of up to 3 g/24 h and 16 presented serum creatinine below 1.5 mg/dL, and 14 developed renal hypertension during follow up. Clinicalmorphological correlation permitted us to conclude (in agreement with the literature) that advanced patient age, intensity of proteinuria, serum creatinine levels above 1.5 mg/dL on the occasion of the first hospital visit, and arterial hypertension are clinical-laboratory factors indicating a poor prognosis for IMG. More advanced staging of glomerular damage, presence of segmental mesangial sclerosis and tubulointerstitial involvement are microscopic factors indicating a poor prognosis for IMG. 相似文献
4.
LUCIANO DALLA LIBERA MARZENA PODHORSKA-OKOLOW BARBARA MARTIN MARIA LINA MASSIMINO ROSANNA BRUGNOLO MARCELLO CANTINI 《Journal of muscle research and cell motility》1997,18(3):295-303
Byusing a polyclonal antibody raised against smooth muscle MyosinLight Chain Kinase of adult chicken we show that the 135 kDasmooth muscle Myosin Light Chain Kinase isoform is present inneonatal and regenerating rat skeletal muscle, as well as inadult atrial myocardium. No reaction was evident in adultskeletal muscle fibres. In neonatal and in early regeneratingmuscle smooth muscle Myosin Light Chain Kinase is associated withembryonic myosin as revealed by their co-presence in musclefibres. Experiments in vitro show the same results in myotubes.In atrial myocardium there is a patchy positivity in certaingroup of myocytes. Immunoblotting experiments show in muscle cellcultures, in neonatal and in regenerating skeletal muscle aprotein band with electrophoretic mobility corresponding to thatof smooth muscle Myosin Light Chain Kinase. These results suggestthat the expression of smooth muscle Myosin Light Chain Kinase isnot fully tissue-specific and that regulation of the contractilemachinery could be different during myogenesis and in adulthood,in relation to the peculiar dynamic characteristics of developingmuscles 相似文献
5.
KODAVANTI URMILA P.; HATCH GARY E.; STARCHER BARRY; GIRI SHRI N.; WINSETT DARRELL; COSTA DANIEL L. 《Toxicological sciences》1995,24(2):154-164
Since Vitamin C (ascorbate, AH2) is an important airway antioxidantand is an essential component of tissue repair, and since acute(4 hr) O3 toxicity is enhanced by AH2 deficiency, we hypothesizedthat longer-term O3 effects might also be increased. FemaleHartley guinea pigs (260330 g) were fed either an AH2-sufficientor an AH2-deficient diet 1 week prior to exposure, and weremaintained on their respective diets during 1 week of continuousexposure to O3 (0, 0.2, 0.4, and 0.8 ppm, 23 hr/day), and during1 week postexposure recovery in clean air. The AH2-deficientdiet caused lung AH2 to drop to about 30% of control in 1 week,and to below 10% by the end of exposure and recovery. Body weightgains during exposure were decreased in the 0.8 ppm O3 group,while the AH2 deficiency began to affect body weights only duringrecovery. O3 caused a concentration-dependent decrease in totallung capacity, vital capacity, carbon monoxide diffusing capacity,nitrogen washout, and static compliance, while increasing forcedexpiratory flow rates and residual or end-expiratory volume(suggestive of pulmonary gas-trapping). The lung/body weightratio and fixed lung displacement volume were also increasedin O3-exposed animals. Lung pathology consisted of mononuclearcell and neutrophil infiltration, airway as well as alveolarepithelial cell hyperplasia, and general decrease in epithelialcell cytoplasm. Thickening of the interstitium and an apparent increase in collagenstaining were seen at the terminal bronchiolar regions. Someof these effects were marginally exacerbated in AH2-defi- cientguinea pigs. One week postexposure to air reversed all O3-inducedabnormalities, irrespective of AH2 deficiency. Whole lung hydroxyprolineand desmosine were not changed at any time by either 03 or AH2deficiency. Measurement of lung prolyl hydroxylase activitysuggested that AH2 deficiency as well as 03 exposure may haveincreased the tissue levels of this enzyme. The lack of a significantincrease in toxicity with the longer-term exposure scenariosuggests that AH2 has minimal influence on other compensatorymechanisms developed over time. 相似文献
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André Luís PORPORATTI Yuri Martins COSTA Paulo César Rodrigues CONTI Leonardo Rigoldi BONJARDIM Patrícia dos Santos CALDERON 《Journal of applied oral science : revista FOB》2015,23(2):129-134
OBJECTIVES:
This cross-sectional study aimed to evaluate the influence of Primary Headache (PH) on efficacy of a Temporomandibular Disorders (TMD) conservative therapy and its association with the presence of self-reported parafunctional habits.SAMPLE AND METHODS:
Sample was composed of 400 medical records, divided into four groups: I) Muscular TMD (n=64); II) Muscular TMD+PH (n=48); III) Muscular TMD+Articular TMD (n=173); IV) Muscular TMD+Articular TMD+PH (n=115). All groups had undergone a TMD therapy for three months with a stabilization appliance and counseling for habits and behavioral changes, with no specific headache management. Current pain intensity and existence or not of self-reported bruxism were assessed. Repeated measures ANOVA and Chi-Square test followed by Odds were used for statistical analysis, with a significance level of 5%.RESULTS:
results of this study showed that: (1) A conservative therapy with stabilization appliance and counseling for habits and behavioral changes was effective in the TMD pain relief; (2) Groups with an additional diagnosis of PH had worsened the pain improvement significantly; and (3) no association between the presence of self-reported bruxism and PH was found.CONCLUSIONS:
this study could elucidate the important effect that headache may have on the TMD management. 相似文献8.
Chronic granulocytic leukaemia (CGL) cells which contained a high concentration of unsaturated folate binding protein were incubated in suspension culture for a period of 5 h. Cell samples were periodically assayed for binder and these demonstrated active synthesis which was inhibited by puromycin, cyclo heximide, N-ethylmaleimide, and by incubation at 4 degrees C, but not by actinomycin D. Folate binding activity could also be demonstrated in the culture medium and this increased with the duration of incubation. This release of binder was inhibited by culturing the cells at 4 degrees C and by the addition of N-ethylmaleimide, but not by actinomycin D, puromycin, or cycloheximide. When the pre- and post-culture cell lysates were saturated with tritiated folic acid ([3H]PteGlu) and subjected to chromatography on DEAE-agrarose, approximately half of the bound folate eluted with 0.001 M phosphate buffer at pH 6.0 and the other half eluted with 0.2 M buffer at pH 7.2. The culture medium and plasma from this patient with CGL was well as serum from two normal subjects saturated with [3H]PteGlu and similarly chromatographed contained primarily the acidic binder and much less of the binder eluting with the low molarity buffer. Since a folate binding protein immunochemically similar to the binder in CGL cells has been identified in the serum of non-leukaemic subjects, these experiments suggest that the source of circulating folate binding protein may be the immature granulocyte. 相似文献
9.
10.
CRISTIANE MARIA DA COSTA‐SILVA FABIANO JEREMIAS JULIANA FELTRIN
De SOUZA RITA
De CÁSSIA LOIOLA CORDEIRO LOURDES SANTOS‐PINTO ANGELA CRISTINA CILENSE ZUANON 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2010,20(6):426-434
International Journal of Paediatric Dentistry 2010; 20: 426–434 Background. The prevalence of molar incisor hypomineralization (MIH) varies considerably around the world; however, few studies have examined MIH in South American countries. Objective. To evaluate the prevalence, severity, and clinical consequences of MIH in Brazilian children residing in rural and urban areas of the municipality of Botelhos, Minas Gerais, Brazil. Methods. Children aged 6 to 12 years (n = 918) with all four‐first permanent molars erupted had these teeth evaluated according to the European Academy of Paediatric Dentistry (EAPD) criteria. The examinations were conducted by two previously trained examiners, and the dental impact caused by MIH was evaluated with the Decayed, Missing and Filled Teeth (DMFT) index (WHO). Results. Molar incisor hypomineralization was present in 19.8% of the 918 children, with a higher prevalence in rural areas. The majority of the defects presented were demarcated opacities without post‐eruptive structural loss, which has been considered as mild defects. Children with MIH had higher DMFT values. Conclusion. Despite the high prevalence of MIH, the severity of the defects was mild. The results indicate a positive association between MIH and the presence of dental caries. 相似文献