全文获取类型
收费全文 | 15458篇 |
免费 | 906篇 |
国内免费 | 65篇 |
专业分类
耳鼻咽喉 | 211篇 |
儿科学 | 330篇 |
妇产科学 | 412篇 |
基础医学 | 1992篇 |
口腔科学 | 1215篇 |
临床医学 | 1292篇 |
内科学 | 3556篇 |
皮肤病学 | 320篇 |
神经病学 | 1369篇 |
特种医学 | 403篇 |
外科学 | 1701篇 |
综合类 | 49篇 |
一般理论 | 5篇 |
预防医学 | 1380篇 |
眼科学 | 277篇 |
药学 | 1076篇 |
中国医学 | 114篇 |
肿瘤学 | 727篇 |
出版年
2023年 | 113篇 |
2022年 | 325篇 |
2021年 | 516篇 |
2020年 | 360篇 |
2019年 | 449篇 |
2018年 | 568篇 |
2017年 | 388篇 |
2016年 | 427篇 |
2015年 | 517篇 |
2014年 | 719篇 |
2013年 | 839篇 |
2012年 | 1199篇 |
2011年 | 1347篇 |
2010年 | 692篇 |
2009年 | 569篇 |
2008年 | 956篇 |
2007年 | 973篇 |
2006年 | 813篇 |
2005年 | 729篇 |
2004年 | 593篇 |
2003年 | 597篇 |
2002年 | 534篇 |
2001年 | 257篇 |
2000年 | 215篇 |
1999年 | 191篇 |
1998年 | 103篇 |
1997年 | 101篇 |
1996年 | 73篇 |
1995年 | 52篇 |
1994年 | 40篇 |
1993年 | 44篇 |
1992年 | 104篇 |
1991年 | 114篇 |
1990年 | 86篇 |
1989年 | 88篇 |
1988年 | 63篇 |
1987年 | 61篇 |
1986年 | 51篇 |
1985年 | 64篇 |
1984年 | 50篇 |
1983年 | 52篇 |
1982年 | 38篇 |
1981年 | 32篇 |
1980年 | 29篇 |
1979年 | 28篇 |
1978年 | 23篇 |
1977年 | 22篇 |
1975年 | 23篇 |
1974年 | 23篇 |
1973年 | 21篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
3.
Iclea Rocha Gama Euclides Marinho Trindade-Filho Suzana Lima Oliveira Nassib Bezerra Bueno Isabelle Tenório Melo Cyro Rego Cabral-Junior Elenita M. Barros Jaqueline A. Galvão Wanessa S. Pereira Raphaela C. Ferreira Bruna R. Domingos Terezinha da Rocha Ataide 《Metabolic brain disease》2015,30(1):93-98
4.
Talita da Silva Mendes de Farias Ariclécio Cunha de Oliveira Sandra Andreotti Fernanda Gaspar do Amaral Patrícia Chimin André Ricardo Alves de Proença Francisco Leonardo Torres Leal Rogério Antonio Laurato Sertié Amanda Baron Campana Andressa Bolsoni Lopes Arnaldo Henrique de Souza José Cipolla‐Neto Fabio Bessa Lima 《Journal of pineal research》2015,58(3):251-261
Melatonin, the main hormone produced by the pineal gland, is secreted in a circadian manner (24‐hr period), and its oscillation influences several circadian biological rhythms, such as the regulation of clock genes expression (chronobiotic effect) and the modulation of several endocrine functions in peripheral tissues. Assuming that the circadian synchronization of clock genes can play a role in the regulation of energy metabolism and it is influenced by melatonin, our study was designed to assess possible alterations as a consequence of melatonin absence on the circadian expression of clock genes in the epididymal adipose tissue of male Wistar rats and the possible metabolic repercussions to this tissue. Our data show that pinealectomy indeed has impacts on molecular events: it abolishes the daily pattern of the expression of Clock, Per2, and Cry1 clock genes and Pparγ expression, significantly increases the amplitude of daily expression of Rev‐erbα, and affects the pattern of and impairs adipokine production, leading to a decrease in leptin levels. However, regarding some metabolic aspects of adipocyte functions, such as its ability to synthesize triacylglycerols from glucose along 24 hr, was not compromised by pinealectomy, although the daily profile of the lipogenic enzymes expression (ATP‐citrate lyase, malic enzyme, fatty acid synthase, and glucose‐6‐phosphate dehydrogenase) was abolished in pinealectomized animals. 相似文献
5.
André Ricardo Adriano Tiago Silveira Lima Maxime Battistella Martine Bagot 《Anais brasileiros de dermatologia》2015,90(6):892-895
Granulomatous slack skin is an indolent T-cell lymphoma, considered to be a
variant of mycosis fungoides. Clinically it is characterized by areas of
redundant skin, wrinkled, inelastic, with variable erythema and
infiltration besides a poikilodermic surface. A differential diagnosis
unknown to most dermatologists is the giant cell tumor of soft tissue,
which is an extremely rare low-grade sarcoma. The authors report a patient
who had undergone extensive surgery because of a primary diagnosis of giant
cell tumor of soft tissue, but which proved to be granulomatous slack skin
after a second interventional procedure with confirmatory
histopathology. 相似文献
6.
Diego Dias da Silva Ana Helena da Rosa Paz Ciro Paz Portinho Elizabeth Obino Cirne Lima Lúcia Maria Kliemann Marcus Vinicius Martins Collares 《Acta cirúrgica brasileira / Sociedade Brasileira para Desenvolvimento Pesquisa em Cirurgia》2020,35(12)
Purpose:This study assessed the regeneration potential of mesenchymal stem cells (MSC) from adipose tissue associated with platelet-rich plasma (PRP) in bone regeneration.Methods:Thirty Wistar rats (Rattus norvegicus albinos) were divided into five groups (according to the grafting material and time to euthanasia): (1) autograft - 14 days (control), (2) autograft - 28 days (control), (3) MSC + PRP - 14 days, (4) MSC + PRP + papaverine - 14 days and (5) MSC + PRP + papaverine - 28 days. After euthanasia, the graft was removed and histological slides were prepared. They were assessed by a blinded pathologist using a previously published histological scale as parameter.Results:There was some degree of neoformed bone trabeculae (NBT) in 93.3% of the samples, as well as osteoblastic activity (OA). The autograft groups (14 and 28 days) had higher levels in the formation of bone trabeculae. Nonparametric data were analyzed using the Wilcoxon-Mann-Whitney test and proved not to be statistically significant at p < 0.05.Conclusions:Experimental parietal bone reconstruction, combining MSC, PRP and papaverine presented regeneration in all groups with no significant difference among them.Key words: Bone Regeneration, Platelet-Rich Plasma, Tissue Engineering, Rats 相似文献
7.
John Lennon Silva Cunha Amanda Almeida Leite Thamiris de Castro Abrantes Lorena Passoni Vervloet Thayn Melo de Lima Morais Gerson de Oliveira Paiva Neto Tatiana Nayara Librio Kimura Snia Maria Soares Ferreira Ricardo Luiz Cavalcanti de Albuquerque‐Júnior Aline Corrêa Abraho Mario Jos Romaach Bruno Augusto Benevenuto de Andrade Oslei Paes de Almeida Ciro Dantas Soares 《Journal of cutaneous pathology》2021,48(1):24-33
8.
9.
Hugo Maia Julio Casoy Tania Correia Luís Freitas Kleber Pimentel Célia Athayde Elsimar Coutinho 《Gynecological endocrinology》2006,22(10):547-551
OBJECTIVES: To determine whether aromatase expression in the eutopic endometrium and adenomyotic foci is affected by previous use of oral contraceptives containing gestodene, and to determine whether changes in cyclooxygenase-2 (COX-2) expression occur in adenomyosis during the menstrual cycle. PATIENT AND METHODS: This was a retrospective cohort study carried out in paraffin-embedded endometrial tissue obtained from patients with a histological diagnosis of adenomyosis obtained during the proliferative (n = 25) and luteal (n = 10) phases of the menstrual cycle and following the use of continuous oral contraception with gestodene/ethinyl estradiol (n = 7). COX-2 and aromatase expression were measured in both eutopic endometrium and adenomyotic foci using immunohistochemical methods. RESULTS: Aromatase expression was detected in 80% of the endometrial slices by immunohistochemistry. In positive cases, aromatase was mainly detected in the stromal cells of the eutopic endometrium, whereas in the adenomyotic foci this expression was negative in the majority of the cases. Oral contraceptives containing gestodene, on the other hand, were effective in suppressing aromatase expression in both eutopic and ectopic endometrium. COX-2 expression was detected by immunohistochemistry in the glandular epithelium of both eutopic endometrium and adenomyotic foci and there were no significant changes in its intensity throughout the menstrual cycle. CONCLUSION: Aromatase expression in the eutopic endometrium and adenomyotic foci is suppressed by oral contraceptives containing gestodene. Increased aromatase activity may be responsible for the persistent COX-2 expression during the luteal phase. 相似文献