全文获取类型
收费全文 | 50845篇 |
免费 | 4117篇 |
国内免费 | 88篇 |
专业分类
耳鼻咽喉 | 455篇 |
儿科学 | 1662篇 |
妇产科学 | 1285篇 |
基础医学 | 6957篇 |
口腔科学 | 805篇 |
临床医学 | 6452篇 |
内科学 | 9610篇 |
皮肤病学 | 901篇 |
神经病学 | 4961篇 |
特种医学 | 1115篇 |
外国民族医学 | 4篇 |
外科学 | 6018篇 |
综合类 | 728篇 |
一般理论 | 55篇 |
预防医学 | 6115篇 |
眼科学 | 760篇 |
药学 | 3437篇 |
中国医学 | 33篇 |
肿瘤学 | 3697篇 |
出版年
2023年 | 322篇 |
2022年 | 508篇 |
2021年 | 1333篇 |
2020年 | 843篇 |
2019年 | 1287篇 |
2018年 | 1391篇 |
2017年 | 1064篇 |
2016年 | 1237篇 |
2015年 | 1273篇 |
2014年 | 1703篇 |
2013年 | 2396篇 |
2012年 | 3597篇 |
2011年 | 3749篇 |
2010年 | 1967篇 |
2009年 | 1731篇 |
2008年 | 3101篇 |
2007年 | 3162篇 |
2006年 | 2947篇 |
2005年 | 2842篇 |
2004年 | 2547篇 |
2003年 | 2274篇 |
2002年 | 2244篇 |
2001年 | 769篇 |
2000年 | 841篇 |
1999年 | 743篇 |
1998年 | 542篇 |
1997年 | 448篇 |
1996年 | 366篇 |
1995年 | 340篇 |
1994年 | 294篇 |
1993年 | 286篇 |
1992年 | 562篇 |
1991年 | 522篇 |
1990年 | 457篇 |
1989年 | 439篇 |
1988年 | 435篇 |
1987年 | 406篇 |
1986年 | 394篇 |
1985年 | 345篇 |
1984年 | 338篇 |
1983年 | 253篇 |
1982年 | 169篇 |
1981年 | 163篇 |
1980年 | 142篇 |
1979年 | 266篇 |
1978年 | 167篇 |
1976年 | 142篇 |
1974年 | 170篇 |
1973年 | 170篇 |
1972年 | 166篇 |
排序方式: 共有10000条查询结果,搜索用时 125 毫秒
1.
Hommes Franziska Mohsenpour Amir Kropff Dana Pilgram Lisa Matusall Svenja von Philipsborn Peter Sell Kerstin 《Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz》2022,65(1):96-106
Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz - Akteure der öffentlichen Gesundheit (Public Health) tragen wesentlich zu Gesundheitsschutz, -förderung und... 相似文献
2.
3.
Kuo-yi Jade Chang MHealthEc MHM BSc Lisa Lorraine Dillon MSpecEd BPsych Lil Deverell COMS PhD MEd GradDipO&M BEd Mei Ying Boon PhD BOptom FAAO Lisa Keay PhD MPH BOptom 《Clinical & experimental optometry》2020,103(4):434-448
Despite orientation and mobility (O&M) being a significant factor determining quality of life of people with low vision or blindness, there are no gold standard measures or agreement on how to measure O&M performance. In the first part of this systematic review, an inventory of O&M outcome measures used by recent studies to assess the performance of orientation and/or mobility of adults with vision impairment (low vision and blindness) is presented. A wide variety of O&M outcome measures have been implemented in different fields of study, such as epidemiologic research and interventional studies evaluating training, assistive technology, vision rehabilitation and vision restoration. The most frequent aspect of outcome measures is efficiency such as time, distance, speed and percentage of preferred walking speed, followed by obstacle contacts and avoidance, and dis/orientation and veering. Other less commonly used aspects are target identification, safety and social interaction and self-reported outcome measures. Some studies employ sophisticated equipment to capture and analyse O&M performance in a laboratory setting, while others carry out their assessment in real-world indoor or outdoor environments. In the second part of this review, the appropriateness of implementing the identified outcome measures to assess O&M performance in clinical and functional O&M practice is evaluated. Nearly a half of these outcome measures meet all four criteria of face validity (either clinical or functional), responsiveness, reliability and feasibility and have the potential to be implemented in clinical or functional O&M practice. The findings of this review confirm the complicated and dynamic nature of O&M. Multiple measures are required in any evaluation of O&M performance to facilitate holistic assessment of O&M abilities and limitations of each individual. 相似文献
4.
5.
6.
Metabolism describes the series of chemical reactions that are concerned with the provision of energy to biological systems. They may be divided into reactions involved in energy yield (catabolism: demand exceeds supply), and energy storage (anabolism: supply exceeds demand). Regulation of these pathways is critical for homeostasis, and derangements in metabolism are seen in a wide variety of pathological processes. Understanding metabolism is key to the treatment of many diseases, notably diabetes, as well as underpinning clinical nutritional support. 相似文献
7.
8.
9.
Weiyu Ye Anna Olsson-Brown Robert A. Watson Vincent T. F. Cheung Robert D. Morgan Isar Nassiri Rosalin Cooper Chelsea A. Taylor Umair Akbani Oliver Brain Rubeta N. Matin Nicholas Coupe Mark R. Middleton Mark Coles Joseph J. Sacco Miranda J. Payne Benjamin P. Fairfax 《British journal of cancer》2021,124(10):1661
Background Immune checkpoint blockers (ICBs) activate CD8+ T cells, eliciting both anti-cancer activity and immune-related adverse events (irAEs). The relationship of irAEs with baseline parameters and clinical outcome is unclear.Methods Retrospective evaluation of irAEs on survival was performed across primary (N = 144) and secondary (N = 211) independent cohorts of patients with metastatic melanoma receiving single agent (pembrolizumab/nivolumab—sICB) or combination (nivolumab and ipilimumab—cICB) checkpoint blockade. RNA from pre-treatment and post-treatment CD8+ T cells was sequenced and differential gene expression according to irAE development assessed.Results 58.3% of patients developed early irAEs and this was associated with longer progression-free (PFS) and overall survival (OS) across both cohorts (log-rank test, OS: P < 0.0001). Median survival for patients without irAEs was 16.6 months (95% CI: 10.9–33.4) versus not-reached (P = 2.8 × 10−6). Pre-treatment monocyte and neutrophil counts, but not BMI, were additional predictors of clinical outcome. Differential expression of numerous gene pathway members was observed in CD8+ T cells according to irAE development, and patients not developing irAEs demonstrating upregulated CXCR1 pre- and post-treatment.Conclusions Early irAE development post-ICB is associated with favourable survival in MM. Development of irAEs is coupled to expression of numerous gene pathways, suggesting irAE development in-part reflects baseline immune activation.Subject terms: Immunotherapy, Melanoma 相似文献
10.